登録情報 | データベース: PDB / ID: 3pt3 |
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タイトル | Crystal structure of the C-terminal lobe of the human UBR5 HECT domain |
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要素 | E3 ubiquitin-protein ligase UBR5 |
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キーワード | LIGASE (リガーゼ) / UBR5 / EDD / hHYD / mixed alpha-beta fold / ubiquitin ligase (ユビキチンリガーゼ) |
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機能・相同性 | 機能・相同性情報
heterochromatin boundary formation / HECT-type E3 ubiquitin transferase / DNA repair-dependent chromatin remodeling / ubiquitin-ubiquitin ligase activity / progesterone receptor signaling pathway / protein K48-linked ubiquitination / ubiquitin binding / protein polyubiquitination / positive regulation of protein import into nucleus / positive regulation of canonical Wnt signaling pathway ...heterochromatin boundary formation / HECT-type E3 ubiquitin transferase / DNA repair-dependent chromatin remodeling / ubiquitin-ubiquitin ligase activity / progesterone receptor signaling pathway / protein K48-linked ubiquitination / ubiquitin binding / protein polyubiquitination / positive regulation of protein import into nucleus / positive regulation of canonical Wnt signaling pathway / ubiquitin protein ligase activity / DNA修復 / DNA damage response / positive regulation of gene expression / perinuclear region of cytoplasm / protein-containing complex / RNA binding / zinc ion binding / 核質 / 生体膜 / 細胞核 / 細胞質基質 / 細胞質類似検索 - 分子機能 Hect, E3 ligase catalytic fold / Hect, E3 ligase catalytic domain / : / E3 ubiquitin ligase EDD, ubiquitin-associated domain / E3 ubiquitin ligase EDD / Polyadenylate-binding protein/Hyperplastic disc protein / Poly-adenylate binding protein, unique domain / Poly(A)-binding protein C-terminal (PABC) domain profile. / C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. / PABC (PABP) domain ...Hect, E3 ligase catalytic fold / Hect, E3 ligase catalytic domain / : / E3 ubiquitin ligase EDD, ubiquitin-associated domain / E3 ubiquitin ligase EDD / Polyadenylate-binding protein/Hyperplastic disc protein / Poly-adenylate binding protein, unique domain / Poly(A)-binding protein C-terminal (PABC) domain profile. / C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. / PABC (PABP) domain / Zinc finger, UBR-type / Zinc finger UBR-type profile. / Putative zinc finger in N-recognin, a recognition component of the N-end rule pathway / Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II / HECT domain / HECT, E3 ligase catalytic domain / HECT-domain (ubiquitin-transferase) / HECT domain profile. / Domain Homologous to E6-AP Carboxyl Terminus with / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.97 Å |
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データ登録者 | Matta-Camacho, E. / Kozlov, G. / Menade, M. / Gehring, K. |
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引用 | ジャーナル: Acta Crystallogr.,Sect.F / 年: 2012 タイトル: Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase. 著者: Matta-Camacho, E. / Kozlov, G. / Menade, M. / Gehring, K. |
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履歴 | 登録 | 2010年12月2日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2012年1月25日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2012年10月17日 | Group: Database references |
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改定 1.2 | 2023年9月6日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details |
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