Entry Database : PDB / ID : 3ij2 Structure visualization Downloads & linksTitle Ligand-receptor structure ComponentsBeta-nerve growth factor Nerve growth factor receptor (TNFR superfamily, member 16) DetailsKeywords HORMONE/PROTEIN BINDING / Receptor and ligand / Cleavage on pair of basic residues / Disulfide bond / Glycoprotein / Growth factor / Phosphoprotein / Secreted / HORMONE-PROTEIN BINDING COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
TRKA activation by NGF / NFG and proNGF binds to p75NTR / NADE modulates death signalling / Regulated proteolysis of p75NTR / NFG and proNGF binds to p75NTR / NADE modulates death signalling / NGF processing / Axonal growth inhibition (RHOA activation) / Axonal growth stimulation / Axonal growth stimulation ... TRKA activation by NGF / NFG and proNGF binds to p75NTR / NADE modulates death signalling / Regulated proteolysis of p75NTR / NFG and proNGF binds to p75NTR / NADE modulates death signalling / NGF processing / Axonal growth inhibition (RHOA activation) / Axonal growth stimulation / Axonal growth stimulation / Frs2-mediated activation / negative regulation of type B pancreatic cell apoptotic process / NRIF signals cell death from the nucleus / NF-kB is activated and signals survival / detection of temperature stimulus / dorsal aorta development / p75NTR recruits signalling complexes / positive regulation of neurotrophin TRK receptor signaling pathway / death receptor activity / PI3K/AKT activation / ARMS-mediated activation / nerve growth factor receptor binding / preprotein binding / positive regulation of odontogenesis of dentin-containing tooth / NRIF signals cell death from the nucleus / p75NTR recruits signalling complexes / negative regulation of hair follicle development / positive regulation of synaptic transmission, cholinergic / Retrograde neurotrophin signalling / negative regulation of fibroblast growth factor receptor signaling pathway / NF-kB is activated and signals survival / negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis / neurotrophin binding / negative regulation of dendritic spine development / positive regulation of neuron maturation / metalloendopeptidase inhibitor activity / positive regulation of myelination / nerve growth factor signaling pathway / regulation of neurotransmitter secretion / nerve development / clathrin-coated endocytic vesicle / positive regulation of collateral sprouting / nerve growth factor binding / peripheral nervous system development / neurotrophin TRKA receptor binding / regulation of release of sequestered calcium ion into cytosol / positive regulation of neural precursor cell proliferation / axon extension / positive regulation of Ras protein signal transduction / regulation of reactive oxygen species metabolic process / negative regulation of mitochondrial depolarization / skin development / regulation of neuron differentiation / hair follicle morphogenesis / positive regulation of Rho protein signal transduction / neuronal cell body membrane / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of stem cell proliferation / skeletal muscle cell differentiation / intracellular glucose homeostasis / odontogenesis of dentin-containing tooth / positive regulation of excitatory postsynaptic potential / Rho protein signal transduction / hair follicle development / fibroblast growth factor receptor signaling pathway / positive regulation of axon extension / positive regulation of DNA binding / coreceptor activity / positive regulation of protein autophosphorylation / extrinsic apoptotic signaling pathway in absence of ligand / sensory perception of pain / dendrite membrane / presynaptic modulation of chemical synaptic transmission / positive regulation of neuron differentiation / negative regulation of angiogenesis / positive regulation of synaptic transmission, glutamatergic / adult locomotory behavior / negative regulation of cell migration / neuron projection morphogenesis / central nervous system development / positive regulation of protein ubiquitination / positive regulation of apoptotic signaling pathway / endosome lumen / cell surface receptor protein tyrosine kinase signaling pathway / axon guidance / intracellular protein transport / growth factor activity / circadian regulation of gene expression / modulation of chemical synaptic transmission / neuromuscular junction / memory / small GTPase binding / positive regulation of neuron projection development / positive regulation of miRNA transcription / positive regulation of protein localization to nucleus / circadian rhythm / cellular response to amyloid-beta / neuron projection development / positive regulation of fibroblast proliferation / cell-cell junction Similarity search - Function Tumour necrosis factor receptor 16 / Tumor necrosis factor receptor 16, N-terminal / Nerve growth factor, beta subunit, mammalian / Tumor necrosis factor receptor member 16, transmembrane domain / Tumor necrosis factor receptor member 16 trans-membrane domain / Nerve growth factor, beta subunit / Nerve growth factor family profile. / Nerve growth factor-related / Nerve growth factor conserved site / Nerve growth factor-like ... Tumour necrosis factor receptor 16 / Tumor necrosis factor receptor 16, N-terminal / Nerve growth factor, beta subunit, mammalian / Tumor necrosis factor receptor member 16, transmembrane domain / Tumor necrosis factor receptor member 16 trans-membrane domain / Nerve growth factor, beta subunit / Nerve growth factor family profile. / Nerve growth factor-related / Nerve growth factor conserved site / Nerve growth factor-like / Nerve growth factor family / Nerve growth factor family signature. / Nerve growth factor (NGF or beta-NGF) / Tumor Necrosis Factor Receptor, subunit A, domain 2 / Tumor Necrosis Factor Receptor, subunit A; domain 2 / TNFR/NGFR family cysteine-rich region domain profile. / TNFR/NGFR cysteine-rich region / TNFR/NGFR family cysteine-rich region signature. / Tumor necrosis factor receptor / nerve growth factor receptor repeats. / TNFR/NGFR cysteine-rich region / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / Death domain profile. / DEATH domain, found in proteins involved in cell death (apoptosis). / Death domain / Death domain / Cystine-knot cytokine / Death-like domain superfamily / Ribbon / Mainly Beta Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 3.75 Å DetailsAuthors Feng, D. / Garcia, K.C. CitationJournal : J.Mol.Biol. / Year : 2010Title : Molecular and structural insight into proNGF engagement of p75NTR and sortilin.Authors : Feng, D. / Kim, T. / Ozkan, E. / Light, M. / Torkin, R. / Teng, K.K. / Hempstead, B.L. / Garcia, K.C. History Deposition Aug 3, 2009 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Jan 12, 2010 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Version format complianceRevision 1.2 Nov 1, 2017 Group : Refinement description / Category : softwareRevision 1.3 Jul 24, 2019 Group : Data collection / Refinement description / Category : softwareItem : _software.classification / _software.contact_author ... _software.classification / _software.contact_author / _software.contact_author_email / _software.location / _software.name / _software.type / _software.version Revision 1.4 Oct 13, 2021 Group : Database references / Category : database_2 / struct_ref_seq_difItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details
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