登録情報 データベース : PDB / ID : 3gnw 構造の表示 ダウンロードとリンクタイトル HCV NS5B polymerase in complex with 1,5 benzodiazepine inhibitor 4c 要素RNA-directed RNA polymerase RNA依存性RNAポリメラーゼ 詳細 キーワード TRANSFERASE (転移酵素) / 1 / 5-Benzodiazepines / Hepatitis C Virus (C型肝炎ウイルス) / NS5b / Polymerase (ポリメラーゼ) / Sulfone / Apoptosis (アポトーシス) / ATP-binding / Capsid protein (カプシド) / Cell membrane (細胞膜) / Endoplasmic reticulum (小胞体) / Envelope protein (エンベロープ (ウイルス)) / Fusion protein (融合タンパク質) / Glycoprotein (糖タンパク質) / Helicase (ヘリカーゼ) / Host-virus interaction / Hydrolase (加水分解酵素) / Interferon antiviral system evasion / Lipid droplet / Lipoprotein (リポタンパク質) / Membrane (生体膜) / Metal-binding / Mitochondrion (ミトコンドリア) / Multifunctional enzyme / Nucleotide-binding / Nucleotidyltransferase / Nucleus (Nucleus) / Oncogene (がん遺伝子) / Palmitate (パルミチン酸) / Phosphoprotein / Protease (プロテアーゼ) / Ribonucleoprotein (核タンパク質) / RNA replication (RNA依存性RNAポリメラーゼ) / RNA-binding / RNA-directed RNA polymerase (RNA依存性RNAポリメラーゼ) / Secreted (分泌) / Serine protease (セリンプロテアーゼ) / SH3-binding / Thiol protease (システインプロテアーゼ) / Transcription (転写 (生物学)) / Transcription regulation / Transmembrane (膜貫通型タンパク質) / Viral nucleoprotein / Virion (ウイルス)機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
hepacivirin / host cell mitochondrial membrane / host cell lipid droplet / symbiont-mediated suppression of host TRAF-mediated signal transduction / transformation of host cell by virus / symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / SH3 domain binding / nucleoside-triphosphate phosphatase ... hepacivirin / host cell mitochondrial membrane / host cell lipid droplet / symbiont-mediated suppression of host TRAF-mediated signal transduction / transformation of host cell by virus / symbiont-mediated perturbation of host cell cycle G1/S transition checkpoint / symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity / symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity / SH3 domain binding / nucleoside-triphosphate phosphatase / protein complex oligomerization / monoatomic ion channel activity / viral nucleocapsid / clathrin-dependent endocytosis of virus by host cell / 加水分解酵素; プロテアーゼ; ペプチド結合加水分解酵素; システインプロテアーゼ / RNA helicase activity / molecular adaptor activity / host cell perinuclear region of cytoplasm / host cell endoplasmic reticulum membrane / symbiont-mediated suppression of host type I interferon-mediated signaling pathway / ヘリカーゼ / ribonucleoprotein complex / induction by virus of host autophagy / RNA依存性RNAポリメラーゼ / virus-mediated perturbation of host defense response / viral RNA genome replication / cysteine-type endopeptidase activity / RNA-dependent RNA polymerase activity / serine-type endopeptidase activity / fusion of virus membrane with host endosome membrane / エンベロープ (ウイルス) / host cell nucleus / virion attachment to host cell / host cell plasma membrane / virion membrane / structural molecule activity / ATP hydrolysis activity / タンパク質分解 / RNA binding / zinc ion binding / ATP binding / 生体膜 類似検索 - 分子機能 : / Hepatitis C virus core protein, chain A superfamily / Hepatitus C virus, Non-structural 5a protein, C-terminal / Hepatitis C virus NS5A, 1B domain superfamily / Hepatitis C virus non-structural protein NS2, C-terminal domain / Hepatitis C virus non-structural protein NS2, N-terminal domain / Hepatitis C virus non-structural protein NS2 / HCV NS5a protein C-terminal region / Hepatitis C virus, Non-structural protein NS4b / Hepatitis C virus, Core protein, N-terminal ... : / Hepatitis C virus core protein, chain A superfamily / Hepatitus C virus, Non-structural 5a protein, C-terminal / Hepatitis C virus NS5A, 1B domain superfamily / Hepatitis C virus non-structural protein NS2, C-terminal domain / Hepatitis C virus non-structural protein NS2, N-terminal domain / Hepatitis C virus non-structural protein NS2 / HCV NS5a protein C-terminal region / Hepatitis C virus, Non-structural protein NS4b / Hepatitis C virus, Core protein, N-terminal / Hepatitis C virus non-structural protein NS4b / Hepatitis C virus capsid protein / Hepatitis C virus, Non-structural protein NS2 / Hepatitis C virus, Non-structural 5a protein / Hepatitis C virus, Non-structural 5a protein, domain 1a / Hepatitis C virus non-structural 5a, 1B domain / NS5A domain 1a superfamily / Hepatitis C virus non-structural 5a protein membrane anchor / Hepatitis C virus non-structural 5a zinc finger domain / Hepatitis C virus non-structural 5a domain 1b / Hepacivirus nonstructural protein 2 (NS2) protease domain profile. / Hepatitis C virus, Non-structural protein NS4a / Hepatitis C virus non-structural protein NS4a / Hepatitis C virus, Core protein, C-terminal / Hepatitis C virus core protein / Hepatitis C virus, Non-structural protein E2/NS1 / Hepatitis C virus non-structural protein E2/NS1 / Hepatitis C virus, Envelope glycoprotein E1 / Hepatitis C virus envelope glycoprotein E1 / RNA dependent RNA polymerase, hepatitis C virus / Viral RNA dependent RNA polymerase / Hepatitis C virus, NS3 protease, Peptidase S29 / Hepatitis C virus NS3 protease / Hepacivirus/Pegivirus NS3 protease domain profile. / DEAD box, Flavivirus / Flavivirus DEAD domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / Reverse transcriptase/Diguanylate cyclase domain / RNA-directed RNA polymerase, catalytic domain / RdRp of positive ssRNA viruses catalytic domain profile. / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / DNA/RNA polymerase superfamily / P-loop containing nucleoside triphosphate hydrolase 類似検索 - ドメイン・相同性生物種 Hepatitis C virus isolate (C型肝炎ウイルス)手法 X線回折 / シンクロトロン / 解像度 : 2.39 Å 詳細データ登録者 Nyanguile, O. / De Bondt, H. 引用ジャーナル : J.Med.Chem. / 年 : 2009タイトル : Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase.著者: Vandyck, K. / Cummings, M.D. / Nyanguile, O. / Boutton, C.W. / Vendeville, S. / McGowan, D. / Devogelaere, B. / Amssoms, K. / Last, S. / Rombauts, K. / Tahri, A. / Lory, P. / Hu, L. / ... 著者 : Vandyck, K. / Cummings, M.D. / Nyanguile, O. / Boutton, C.W. / Vendeville, S. / McGowan, D. / Devogelaere, B. / Amssoms, K. / Last, S. / Rombauts, K. / Tahri, A. / Lory, P. / Hu, L. / Beauchamp, D.A. / Simmen, K. / Raboisson, P. 履歴 登録 2009年3月18日 登録サイト : RCSB / 処理サイト : PDBJ改定 1.0 2009年10月20日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Source and taxonomy / Version format compliance改定 1.2 2017年11月1日 Group : Refinement description / カテゴリ : software改定 1.3 2023年11月1日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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