Entry | Database: PDB / ID: 3cos |
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Title | Crystal structure of human class II alcohol dehydrogenase (ADH4) in complex with NAD and Zn |
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Components | Alcohol dehydrogenase 4 |
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Keywords | OXIDOREDUCTASE / medium chain dehydrogenase / alcohol dehydrogenase / Zinc-dependent / Metal-binding / NAD / Structural Genomics / Structural Genomics Consortium / SGC |
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Function / homology | Function and homology information
benzaldehyde dehydrogenase [NAD(P)+] activity / alcohol catabolic process / quinone metabolic process / ethanol binding / all-trans-retinol dehydrogenase (NAD+) / all-trans retinal binding / fatty acid omega-oxidation / NADPH:quinone reductase activity / S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity / alcohol metabolic process ...benzaldehyde dehydrogenase [NAD(P)+] activity / alcohol catabolic process / quinone metabolic process / ethanol binding / all-trans-retinol dehydrogenase (NAD+) / all-trans retinal binding / fatty acid omega-oxidation / NADPH:quinone reductase activity / S-(hydroxymethyl)glutathione dehydrogenase (NAD(P)+) activity / alcohol metabolic process / formaldehyde catabolic process / Ethanol oxidation / cellular aldehyde metabolic process / RA biosynthesis pathway / alcohol dehydrogenase (NAD+) activity / oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor / alcohol dehydrogenase (NAD+) activity, zinc-dependent / : / all-trans-retinol dehydrogenase (NAD+) activity / retinol metabolic process / aldose reductase (NADPH) activity / retinoid metabolic process / retinol binding / NAD binding / zinc ion binding / nucleoplasm / cytosolSimilarity search - Function Alcohol dehydrogenase family, zinc-type, class-II subfamily / Alcohol dehydrogenase, zinc-type, conserved site / Zinc-containing alcohol dehydrogenases signature. / Quinone Oxidoreductase; Chain A, domain 1 / Medium-chain alcohol dehydrogenases, catalytic domain / Alcohol dehydrogenase-like, C-terminal / Zinc-binding dehydrogenase / Alcohol dehydrogenase, N-terminal / Alcohol dehydrogenase GroES-like domain / Polyketide synthase, enoylreductase domain ...Alcohol dehydrogenase family, zinc-type, class-II subfamily / Alcohol dehydrogenase, zinc-type, conserved site / Zinc-containing alcohol dehydrogenases signature. / Quinone Oxidoreductase; Chain A, domain 1 / Medium-chain alcohol dehydrogenases, catalytic domain / Alcohol dehydrogenase-like, C-terminal / Zinc-binding dehydrogenase / Alcohol dehydrogenase, N-terminal / Alcohol dehydrogenase GroES-like domain / Polyketide synthase, enoylreductase domain / Enoylreductase / GroES-like superfamily / NAD(P)-binding Rossmann-like Domain / NAD(P)-binding domain superfamily / Alpha-Beta Complex / Rossmann fold / 3-Layer(aba) Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | ![](img/tx_human.gif) Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.1 Å |
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Authors | Kavanagh, K.L. / Shafqat, N. / Yue, W. / von Delft, F. / Bishop, S. / Roos, A. / Murray, J. / Edwards, A.M. / Arrowsmith, C.H. / Bountra, C. ...Kavanagh, K.L. / Shafqat, N. / Yue, W. / von Delft, F. / Bishop, S. / Roos, A. / Murray, J. / Edwards, A.M. / Arrowsmith, C.H. / Bountra, C. / Oppermann, U. / Structural Genomics Consortium (SGC) |
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Citation | Journal: To be Published Title: Crystal structure of human class II alcohol dehydrogenase (ADH4) in complex with NAD and Zn. Authors: Kavanagh, K.L. / Shafqat, N. / Yue, W. / von Delft, F. / Bishop, S. / Roos, A. / Murray, J. / Edwards, A.M. / Arrowsmith, C.H. / Bountra, C. / Oppermann, U. |
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History | Deposition | Mar 29, 2008 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Apr 15, 2008 | Provider: repository / Type: Initial release |
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Revision 1.1 | Jul 13, 2011 | Group: Advisory / Version format compliance |
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Revision 1.2 | Oct 25, 2017 | Group: Refinement description / Category: software / Item: _software.name |
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Revision 1.3 | Aug 30, 2023 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ncs_dom_lim / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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