natural killer cell mediated immunity / inhibitory MHC class Ib receptor activity / CD8-positive, gamma-delta intraepithelial T cell differentiation / MHC class Ib protein binding, via antigen binding groove / HLA-E specific inhibitory MHC class Ib receptor activity / natural killer cell inhibitory signaling pathway / peripheral B cell tolerance induction / positive regulation of tolerance induction / negative regulation of dendritic cell differentiation / immune response-inhibiting cell surface receptor signaling pathway ...natural killer cell mediated immunity / inhibitory MHC class Ib receptor activity / CD8-positive, gamma-delta intraepithelial T cell differentiation / MHC class Ib protein binding, via antigen binding groove / HLA-E specific inhibitory MHC class Ib receptor activity / natural killer cell inhibitory signaling pathway / peripheral B cell tolerance induction / positive regulation of tolerance induction / negative regulation of dendritic cell differentiation / immune response-inhibiting cell surface receptor signaling pathway / MHC class I protein complex binding / regulation of natural killer cell activation / positive regulation of antibody-dependent cellular cytotoxicity / regulation of natural killer cell mediated immunity / positive regulation of TRAIL production / antigen processing and presentation of exogenous peptide antigen via MHC class Ib / negative regulation of T cell mediated cytotoxicity / MHC class Ib protein complex / positive regulation of natural killer cell mediated immunity / positive regulation of natural killer cell cytokine production / natural killer cell tolerance induction / natural killer cell lectin-like receptor binding / negative regulation of natural killer cell activation / positive regulation of natural killer cell activation / cis-Golgi network membrane / positive regulation of T cell tolerance induction / protein antigen binding / negative regulation of natural killer cell mediated cytotoxicity / positive regulation of natural killer cell mediated cytotoxicity / negative regulation of G0 to G1 transition / positive regulation of interleukin-13 production / negative regulation of immune response / positive regulation of regulatory T cell differentiation / positive regulation of endothelial cell apoptotic process / filopodium membrane / positive regulation of macrophage cytokine production / positive regulation of natural killer cell proliferation / positive regulation of immunoglobulin production / positive regulation of CD8-positive, alpha-beta T cell activation / CD8-positive, alpha-beta T cell activation / positive regulation of CD8-positive, alpha-beta T cell proliferation / CD8 receptor binding / positive regulation of interleukin-4 production / protein homotrimerization / MHC class I protein binding / stimulatory C-type lectin receptor signaling pathway / protection from natural killer cell mediated cytotoxicity / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cellular defense response / beta-2-microglobulin binding / T cell receptor binding / negative regulation of T cell proliferation / positive regulation of interleukin-12 production / negative regulation of angiogenesis / antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent / antigen processing and presentation of endogenous peptide antigen via MHC class Ib / positive regulation of ferrous iron binding / positive regulation of transferrin receptor binding / positive regulation of receptor binding / early endosome lumen / Nef mediated downregulation of MHC class I complex cell surface expression / DAP12 interactions / negative regulation of receptor binding / lumenal side of endoplasmic reticulum membrane / Endosomal/Vacuolar pathway / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / cellular response to iron(III) ion / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / negative regulation of forebrain neuron differentiation / ER to Golgi transport vesicle membrane / regulation of erythrocyte differentiation / peptide antigen assembly with MHC class I protein complex / response to molecule of bacterial origin / regulation of iron ion transport / MHC class I peptide loading complex / HFE-transferrin receptor complex / T cell mediated cytotoxicity / cellular response to iron ion / antigen processing and presentation of endogenous peptide antigen via MHC class I / positive regulation of T cell cytokine production / MHC class I protein complex / multicellular organismal-level iron ion homeostasis / negative regulation of neurogenesis / peptide antigen assembly with MHC class II protein complex / positive regulation of receptor-mediated endocytosis / MHC class II protein complex / cellular response to nicotine / positive regulation of T cell mediated cytotoxicity / recycling endosome membrane / specific granule lumen / phagocytic vesicle membrane / peptide antigen binding / transmembrane signaling receptor activity / positive regulation of cellular senescence / antigen processing and presentation of exogenous peptide antigen via MHC class II / negative regulation of epithelial cell proliferation / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / positive regulation of tumor necrosis factor production / Interferon gamma signaling / positive regulation of immune response 類似検索 - 分子機能
Natural killer cell receptor-like, C-type lectin-like domain / Lectin C-type domain / C-type lectin domain profile. / C-type lectin-like / C-type lectin (CTL) or carbohydrate-recognition domain (CRD) / C-type lectin-like/link domain superfamily / C-type lectin fold / MHC class I, alpha chain, C-terminal / MHC_I C-terminus / MHC class I alpha chain, alpha1 alpha2 domains ...Natural killer cell receptor-like, C-type lectin-like domain / Lectin C-type domain / C-type lectin domain profile. / C-type lectin-like / C-type lectin (CTL) or carbohydrate-recognition domain (CRD) / C-type lectin-like/link domain superfamily / C-type lectin fold / MHC class I, alpha chain, C-terminal / MHC_I C-terminus / MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Β2-ミクログロブリン / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold 類似検索 - ドメイン・相同性
HLA class I histocompatibility antigen, alpha chain E / HLA class I histocompatibility antigen, alpha chain G / NKG2-A/NKG2-B type II integral membrane protein / Β2-ミクログロブリン / Natural killer cells antigen CD94 類似検索 - 構成要素
A: HLA class I histocompatibility antigen, alpha chain E B: Beta-2-microglobulin C: HLA class I histocompatibility antigen peptide D: HLA class I histocompatibility antigen, alpha chain E E: Beta-2-microglobulin F: HLA class I histocompatibility antigen peptide G: Natural killer cells antigen CD94 H: NKG2-A/NKG2-B type II integral membrane protein I: Natural killer cells antigen CD94 J: NKG2-A/NKG2-B type II integral membrane protein
A: HLA class I histocompatibility antigen, alpha chain E B: Beta-2-microglobulin C: HLA class I histocompatibility antigen peptide G: Natural killer cells antigen CD94 H: NKG2-A/NKG2-B type II integral membrane protein
D: HLA class I histocompatibility antigen, alpha chain E E: Beta-2-microglobulin F: HLA class I histocompatibility antigen peptide I: Natural killer cells antigen CD94 J: NKG2-A/NKG2-B type II integral membrane protein
分子量: 1048.321 Da / 分子数: 2 / 断片: peptide presented by HLA-E (UNP residues 3-11) / 由来タイプ: 合成 詳細: peptide is naturally found in humans and was chemically synthesized. 参照: UniProt: P17693
#4: タンパク質
NaturalkillercellsantigenCD94 / NK cell receptor / Killer cell lectin-like receptor subfamily D member 1 / KP43
解像度: 4.41→67.88 Å / Cor.coef. Fo:Fc: 0.753 / Cor.coef. Fo:Fc free: 0.68 / SU B: 136.822 / SU ML: 0.792 / TLS residual ADP flag: LIKELY RESIDUAL / 交差検証法: THROUGHOUT / ESU R Free: 1.096 / 立体化学のターゲット値: MAXIMUM LIKELIHOOD / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS
Rfactor
反射数
%反射
Selection details
Rfree
0.35529
1155
5.1 %
RANDOM
Rwork
0.32054
-
-
-
all
-
22600
-
-
obs
-
21445
99.95 %
-
溶媒の処理
イオンプローブ半径: 0.8 Å / 減衰半径: 0.8 Å / VDWプローブ半径: 1.4 Å / 溶媒モデル: MASK