登録情報 データベース : PDB / ID : 3bt2 構造の表示 ダウンロードとリンクタイトル Structure of urokinase receptor, urokinase and vitronectin complex 要素(anti-uPAR antibody, ...) x 2 Urokinase plasminogen activator surface receptor Urokinase receptor Urokinase-type plasminogen activator ウロキナーゼ Vitronectin ビトロネクチン 詳細キーワード IMMUNE SYSTEM (免疫系) / protein-protein interaction (タンパク質間相互作用) / Glycoprotein (糖タンパク質) / GPI-anchor (グリコシルホスファチジルイノシトール) / Lipoprotein (リポタンパク質) / Membrane (生体膜) / Receptor / Secreted (分泌) / Blood coagulation (凝固・線溶系) / EGF-like domain (EGF様ドメイン) / Fibrinolysis / Hydrolase (加水分解酵素) / Kringle / Phosphoprotein / Plasminogen activation / Protease (プロテアーゼ) / Serine protease (セリンプロテアーゼ) / Zymogen (酵素前駆体) / Cell adhesion (細胞接着) / Heparin-binding / Sulfation / Immunoglobulin domain (免疫グロブリンフォールド)機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
urokinase plasminogen activator receptor activity / Attachment of GPI anchor to uPAR / rough endoplasmic reticulum lumen / smooth muscle cell-matrix adhesion / peptidase inhibitor complex / positive regulation of homotypic cell-cell adhesion / negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / alphav-beta3 integrin-vitronectin complex / ウロキナーゼ / regulation of smooth muscle cell-matrix adhesion ... urokinase plasminogen activator receptor activity / Attachment of GPI anchor to uPAR / rough endoplasmic reticulum lumen / smooth muscle cell-matrix adhesion / peptidase inhibitor complex / positive regulation of homotypic cell-cell adhesion / negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway / alphav-beta3 integrin-vitronectin complex / ウロキナーゼ / regulation of smooth muscle cell-matrix adhesion / scavenger receptor activity / urokinase plasminogen activator signaling pathway / regulation of plasminogen activation / regulation of fibrinolysis / negative regulation of endopeptidase activity / regulation of wound healing / protein complex involved in cell-matrix adhesion / regulation of proteolysis / negative regulation of plasminogen activation / negative regulation of blood coagulation / regulation of smooth muscle cell migration / regulation of signaling receptor activity / extracellular matrix binding / positive regulation of vascular endothelial growth factor receptor signaling pathway / serine-type endopeptidase complex / Dissolution of Fibrin Clot / positive regulation of cell-substrate adhesion / Molecules associated with elastic fibres / smooth muscle cell migration / cell adhesion mediated by integrin / extracellular matrix structural constituent / positive regulation of epidermal growth factor receptor signaling pathway / Syndecan interactions / polysaccharide binding / extrinsic component of membrane / positive regulation of wound healing / plasminogen activation / positive regulation of smooth muscle cell migration / oligodendrocyte differentiation / endodermal cell differentiation / positive regulation of release of cytochrome c from mitochondria / regulation of cell adhesion mediated by integrin / tertiary granule membrane / protein polymerization / 基底膜 / ECM proteoglycans / positive regulation of DNA binding / Integrin cell surface interactions / negative regulation of fibrinolysis / negative regulation of intrinsic apoptotic signaling pathway / specific granule membrane / regulation of cell adhesion / serine protease inhibitor complex / fibrinolysis / collagen binding / extracellular matrix organization / cell-matrix adhesion / cell projection / Regulation of Complement cascade / liver regeneration / Golgi lumen / positive regulation of receptor-mediated endocytosis / 走化性 / 遊走 / positive regulation of peptidyl-tyrosine phosphorylation / 凝固・線溶系 / integrin binding / positive regulation of protein binding / signaling receptor activity / heparin binding / regulation of cell population proliferation / collagen-containing extracellular matrix / blood microparticle / response to hypoxia / 細胞接着 / positive regulation of cell migration / 免疫応答 / positive regulation of protein phosphorylation / protein domain specific binding / external side of plasma membrane / 小胞体 / signaling receptor binding / serine-type endopeptidase activity / focal adhesion / intracellular membrane-bounded organelle / Neutrophil degranulation / endoplasmic reticulum membrane / negative regulation of apoptotic process / enzyme binding / 細胞膜 / 小胞体 / シグナル伝達 / タンパク質分解 / extracellular space / extracellular exosome / extracellular region / 生体膜 / identical protein binding / 細胞膜 類似検索 - 分子機能 CD59 antigen, conserved site / Ly-6 / u-PAR domain signature. / Ly-6 antigen / uPA receptor -like domain / u-PAR/Ly-6 domain / Ly-6 antigen/uPA receptor-like / Somatomedin B domain, chordata / Somatomedin B -like domains / Somatomedin B domain / Somatomedin B-like domain superfamily / Somatomedin B domain ... CD59 antigen, conserved site / Ly-6 / u-PAR domain signature. / Ly-6 antigen / uPA receptor -like domain / u-PAR/Ly-6 domain / Ly-6 antigen/uPA receptor-like / Somatomedin B domain, chordata / Somatomedin B -like domains / Somatomedin B domain / Somatomedin B-like domain superfamily / Somatomedin B domain / Somatomedin B domain (SMB) signature. / Somatomedin B (SMB) domain profile. / Plasminogen Kringle 4 / Plasminogen Kringle 4 / CD59 / CD59 / Hemopexin, conserved site / Hemopexin domain signature. / Hemopexin-like domain / Hemopexin-like repeats / Hemopexin-like domain superfamily / ヘモペキシン / Hemopexin repeat profile. / Hemopexin-like repeats. / Snake toxin-like superfamily / ラミニン / ラミニン / Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / Kringle-like fold / EGF-like domain profile. / EGF-like domain signature 1. / EGF様ドメイン / リボン / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / トリプシン / 抗体 / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Immunoglobulin-like / Βバレル / サンドイッチ / Mainly Beta 類似検索 - ドメイン・相同性 ウロキナーゼ / ビトロネクチン / Urokinase plasminogen activator surface receptor 類似検索 - 構成要素生物種 Homo sapiens (ヒト)Mus musculus (ハツカネズミ)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.5 Å 詳細データ登録者 Huang, M. 引用ジャーナル : Nat.Struct.Mol.Biol. / 年 : 2008タイトル : Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes著者 : Huai, Q. / Zhou, A. / Lin, L. / Mazar, A.P. / Parry, G.C. / Callahan, J. / Shaw, D.E. / Furie, B. / Furie, B.C. / Huang, M. 履歴 登録 2007年12月27日 登録サイト : RCSB / 処理サイト : PDBJ改定 1.0 2008年3月25日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Advisory / Version format compliance改定 2.0 2020年7月29日 Group : Advisory / Atomic model ... Advisory / Atomic model / Data collection / Database references / Derived calculations / Structure summary カテゴリ : atom_site / chem_comp ... atom_site / chem_comp / database_PDB_caveat / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / struct_asym / struct_conn / struct_ref_seq / struct_ref_seq_dif / struct_site / struct_site_gen Item : _atom_site.B_iso_or_equiv / _atom_site.Cartn_x ... _atom_site.B_iso_or_equiv / _atom_site.Cartn_x / _atom_site.Cartn_y / _atom_site.Cartn_z / _atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _chem_comp.name / _chem_comp.type / _pdbx_entity_nonpoly.entity_id / _pdbx_entity_nonpoly.name / _pdbx_struct_assembly_gen.asym_id_list / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_ref_seq.db_align_end / _struct_ref_seq_dif.details 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 2.1 2023年11月1日 Group : Data collection / Database references ... Data collection / Database references / Refinement description / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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