登録情報 データベース : PDB / ID : 2yu7 構造の表示 ダウンロードとリンクタイトル Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A 要素Tyrosine-protein phosphatase non-receptor type 6 natural killer group 2A 詳細キーワード SIGNALING PROTEIN / SH2 domain (SH2ドメイン) / Protein-peptide complex / Phosphorylated peptide recognition / Phosphotyrosine binding domain / Signal Transduction (シグナル伝達) / Structural Genomics (構造ゲノミクス) / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
inhibitory MHC class Ib receptor activity / CD8-positive, gamma-delta intraepithelial T cell differentiation / HLA-E specific inhibitory MHC class Ib receptor activity / natural killer cell inhibitory signaling pathway / negative regulation of humoral immune response mediated by circulating immunoglobulin / negative regulation of mast cell activation involved in immune response / MHC class I protein complex binding / regulation of B cell differentiation / regulation of natural killer cell activation / negative regulation of peptidyl-tyrosine phosphorylation ... inhibitory MHC class Ib receptor activity / CD8-positive, gamma-delta intraepithelial T cell differentiation / HLA-E specific inhibitory MHC class Ib receptor activity / natural killer cell inhibitory signaling pathway / negative regulation of humoral immune response mediated by circulating immunoglobulin / negative regulation of mast cell activation involved in immune response / MHC class I protein complex binding / regulation of B cell differentiation / regulation of natural killer cell activation / negative regulation of peptidyl-tyrosine phosphorylation / negative regulation of T cell mediated cytotoxicity / epididymis development / negative regulation of inflammatory response to wounding / phosphorylation-dependent protein binding / transmembrane receptor protein tyrosine phosphatase activity / negative regulation of natural killer cell mediated cytotoxicity / positive regulation of natural killer cell mediated cytotoxicity / natural killer cell mediated cytotoxicity / alpha-beta T cell receptor complex / regulation of release of sequestered calcium ion into cytosol / CD22 mediated BCR regulation / Interleukin-37 signaling / positive regulation of cell adhesion mediated by integrin / Costimulation by the CD28 family / Signal regulatory protein family interactions / platelet formation / megakaryocyte development / negative regulation of T cell receptor signaling pathway / negative regulation of MAPK cascade / Regulation of KIT signaling / Signaling by ALK / Platelet sensitization by LDL / regulation of G1/S transition of mitotic cell cycle / stimulatory C-type lectin receptor signaling pathway / PECAM1 interactions / negative regulation of interleukin-6 production / regulation of type I interferon-mediated signaling pathway / non-membrane spanning protein tyrosine phosphatase activity / negative regulation of tumor necrosis factor production / peptidyl-tyrosine dephosphorylation / Interleukin-3, Interleukin-5 and GM-CSF signaling / Regulation of IFNA/IFNB signaling / PD-1 signaling / Nuclear events stimulated by ALK signaling in cancer / Interleukin receptor SHC signaling / hematopoietic progenitor cell differentiation / Regulation of IFNG signaling / T cell proliferation / Growth hormone receptor signaling / negative regulation of T cell proliferation / GPVI-mediated activation cascade / cell adhesion molecule binding / T cell costimulation / phosphotyrosine residue binding / SH2 domain binding / protein dephosphorylation / プロテインチロシンホスファターゼ / regulation of ERK1 and ERK2 cascade / Antigen activates B Cell Receptor (BCR) leading to generation of second messengers / protein tyrosine phosphatase activity / B cell receptor signaling pathway / 血小板 / cytokine-mediated signaling pathway / SH3 domain binding / peptidyl-tyrosine phosphorylation / specific granule lumen / transmembrane signaling receptor activity / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / Interferon gamma signaling / 分裂促進因子活性化タンパク質キナーゼ / Interferon alpha/beta signaling / cell-cell junction / tertiary granule lumen / mitotic cell cycle / T cell receptor signaling pathway / carbohydrate binding / regulation of apoptotic process / 獲得免疫系 / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / cell surface receptor signaling pathway / 細胞分化 / receptor complex / intracellular signal transduction / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / external side of plasma membrane / 自然免疫系 / Neutrophil degranulation / positive regulation of cell population proliferation / 核小体 / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / protein-containing complex / extracellular exosome / extracellular region / 核質 / 生体膜 / 細胞核 / 細胞膜 / 細胞質基質 類似検索 - 分子機能 Natural killer cell receptor-like, C-type lectin-like domain / Protein-tyrosine phosphatase, non-receptor type-6, -11 / SH2ドメイン / SHC Adaptor Protein / Lectin C-type domain / C-type lectin domain profile. / C-type lectin-like / C-type lectin (CTL) or carbohydrate-recognition domain (CRD) / C-type lectin-like/link domain superfamily / C-type lectin fold ... Natural killer cell receptor-like, C-type lectin-like domain / Protein-tyrosine phosphatase, non-receptor type-6, -11 / SH2ドメイン / SHC Adaptor Protein / Lectin C-type domain / C-type lectin domain profile. / C-type lectin-like / C-type lectin (CTL) or carbohydrate-recognition domain (CRD) / C-type lectin-like/link domain superfamily / C-type lectin fold / Protein tyrosine phosphatase, catalytic domain / PTP type protein phosphatase domain profile. / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine specific protein phosphatases active site. / Protein-tyrosine phosphatase, active site / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / SH2ドメイン / Src homology 2 (SH2) domain profile. / Src homology 2 domains / SH2ドメイン / SH2 domain superfamily / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性 NKG2-A/NKG2-B type II integral membrane protein / Tyrosine-protein phosphatase non-receptor type 6 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 溶液NMR / torsion angle dynamics , restrained molecular dynamics 詳細データ登録者 Kasai, T. / Koshiba, S. / Inoue, M. / Kigawa, T. / Yokoyama, S. / RIKEN Structural Genomics/Proteomics Initiative (RSGI) 引用ジャーナル : To be Published タイトル : Solution structure of the SHP-1 C-terminal SH2 domain complexed with a tyrosine-phosphorylated peptide from NKG2A著者 : Kasai, T. / Koshiba, S. / Inoue, M. / Kigawa, T. / Yokoyama, S. 履歴 登録 2007年4月5日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2008年4月15日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2022年3月16日 Group : Data collection / Database references / Derived calculationsカテゴリ : database_2 / pdbx_nmr_software ... database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conn / struct_ref_seq_dif Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_conn.pdbx_leaving_atom_flag / _struct_ref_seq_dif.details
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