登録情報 | データベース: PDB / ID: 2yt1 |
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タイトル | Solution structure of the chimera of the C-terminal tail peptide of APP and the C-terminal PID domain of Fe65L |
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要素 | Amyloid beta A4 protein and Amyloid beta A4 precursor protein-binding family B member 2 |
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キーワード | PROTEIN BINDING (タンパク質) / Chimera / Fe65L / PID domain / amyloid precursor protein (アミロイド前駆体タンパク質) / Structural Genomics (構造ゲノミクス) / NPPSFA / National Project on Protein Structural and Functional Analyses / RIKEN Structural Genomics/Proteomics Initiative / RSGI |
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機能・相同性 | 機能・相同性情報
negative regulation of cell cycle phase transition / positive regulation of protein import / regulation of response to calcium ion / regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway / positive regulation of response to endoplasmic reticulum stress / Formyl peptide receptors bind formyl peptides and many other ligands / amyloid-beta complex / positive regulation of G protein-coupled receptor internalization / growth cone lamellipodium / Advanced glycosylation endproduct receptor signaling ...negative regulation of cell cycle phase transition / positive regulation of protein import / regulation of response to calcium ion / regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway / positive regulation of response to endoplasmic reticulum stress / Formyl peptide receptors bind formyl peptides and many other ligands / amyloid-beta complex / positive regulation of G protein-coupled receptor internalization / growth cone lamellipodium / Advanced glycosylation endproduct receptor signaling / cellular response to norepinephrine stimulus / growth cone filopodium / endosome to plasma membrane transport vesicle / ECM proteoglycans / regulation of dendritic spine maintenance / maintenance of lens transparency / negative regulation of blood circulation / Insertion of tail-anchored proteins into the endoplasmic reticulum membrane / positive regulation of endothelin production / TRAF6 mediated NF-kB activation / Lysosome Vesicle Biogenesis / protein trimerization / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / Post-translational protein phosphorylation / G alpha (q) signalling events / TAK1-dependent IKK and NF-kappa-B activation / G alpha (i) signalling events / response to yeast / Platelet degranulation / リポタンパク質 / peptidase activator activity / intermediate-density lipoprotein particle / growth factor receptor binding / regulation of amyloid-beta clearance / positive regulation of G protein-coupled receptor signaling pathway / RAGE receptor binding / antifungal humoral response / astrocyte projection / regulation of amyloid fibril formation / low-density lipoprotein particle / very-low-density lipoprotein particle / ion binding / : / frizzled binding / signaling receptor activator activity / cytosolic mRNA polyadenylation / collateral sprouting in absence of injury / microglia development / high-density lipoprotein particle / regulation of synapse structure or activity / axo-dendritic transport / synaptic assembly at neuromuscular junction / acetylcholine receptor binding / smooth endoplasmic reticulum calcium ion homeostasis / heparan sulfate proteoglycan binding / positive regulation of extrinsic apoptotic signaling pathway / axon midline choice point recognition / positive regulation of monocyte chemotaxis / astrocyte activation involved in immune response / negative regulation of protein localization to nucleus / regulation of spontaneous synaptic transmission / mating behavior / positive regulation of membrane protein ectodomain proteolysis / 繊毛 / main axon / PTB domain binding / Golgi-associated vesicle / positive regulation of amyloid fibril formation / neuron remodeling / regulation of toll-like receptor signaling pathway / nuclear envelope lumen / suckling behavior / presynaptic active zone / dendrite development / COPII-coated ER to Golgi transport vesicle / neuronal dense core vesicle / chemoattractant activity / positive regulation of protein kinase A signaling / modulation of excitatory postsynaptic potential / 学習 / apolipoprotein binding / positive regulation of excitatory postsynaptic potential / neuromuscular process controlling balance / regulation of presynapse assembly / transition metal ion binding / regulation of multicellular organism growth / intracellular copper ion homeostasis / negative regulation of long-term synaptic potentiation / negative regulation of neuron differentiation / smooth muscle contraction / 小胞体 / positive regulation of T cell migration / spindle midzone / positive regulation of cAMP-mediated signaling / positive regulation of calcium-mediated signaling / クラスリン / regulation of peptidyl-tyrosine phosphorylation / positive regulation of chemokine production / forebrain development / Notchシグナリング類似検索 - 分子機能 Amyloid beta precursor protein binding family B member 1/2/3 / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / Amyloidogenic glycoprotein, copper-binding / Amyloidogenic glycoprotein, copper-binding domain conserved site / Amyloidogenic glycoprotein, copper-binding domain superfamily / Copper-binding of amyloid precursor, CuBD / Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. ...Amyloid beta precursor protein binding family B member 1/2/3 / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / Amyloidogenic glycoprotein, copper-binding / Amyloidogenic glycoprotein, copper-binding domain conserved site / Amyloidogenic glycoprotein, copper-binding domain superfamily / Copper-binding of amyloid precursor, CuBD / Amyloid precursor protein (APP) copper-binding (CuBD) domain signature. / Beta-amyloid peptide (beta-APP) / Amyloidogenic glycoprotein, amyloid-beta peptide / Beta-amyloid precursor protein C-terminal / Amyloidogenic glycoprotein, intracellular domain, conserved site / Beta-amyloid precursor protein C-terminus / Amyloid precursor protein (APP) intracellular domain signature. / Amyloid precursor protein (APP) E1 domain profile. / Amyloid precursor protein (APP) E2 domain profile. / Amyloidogenic glycoprotein, extracellular / Amyloidogenic glycoprotein, heparin-binding / Amyloidogenic glycoprotein, E2 domain / E2 domain superfamily / Amyloidogenic glycoprotein, heparin-binding domain superfamily / Amyloid A4 N-terminal heparin-binding / E2 domain of amyloid precursor protein / amyloid A4 / Amyloidogenic glycoprotein / Proteinase inhibitor I2, Kunitz, conserved site / Pancreatic trypsin inhibitor (Kunitz) family signature. / BPTI/Kunitz family of serine protease inhibitors. / Pancreatic trypsin inhibitor Kunitz domain / Kunitz/Bovine pancreatic trypsin inhibitor domain / Pancreatic trypsin inhibitor (Kunitz) family profile. / Pancreatic trypsin inhibitor Kunitz domain superfamily / WWドメイン / WW/rsp5/WWP domain signature. / WW domain superfamily / WW/rsp5/WWP domain profile. / Domain with 2 conserved Trp (W) residues / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / WWドメイン / PH-domain like / PH-like domain superfamily / Roll / Mainly Beta類似検索 - ドメイン・相同性 アミロイド前駆体タンパク質 / Amyloid beta precursor protein binding family B member 2類似検索 - 構成要素 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | 溶液NMR / torsion angle dynamics |
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データ登録者 | Li, H. / Koshiba, S. / Watanabe, S. / Harada, T. / Kigawa, T. / Yokoyama, S. / RIKEN Structural Genomics/Proteomics Initiative (RSGI) |
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引用 | ジャーナル: J.Biol.Chem. / 年: 2008 タイトル: Structure of the C-terminal phosphotyrosine interaction domain of Fe65L1 complexed with the cytoplasmic tail of amyloid precursor protein reveals a novel peptide binding mode 著者: Li, H. / Koshiba, S. / Hayashi, F. / Tochio, N. / Tomizawa, T. / Kasai, T. / Yabuki, T. / Motoda, Y. / Harada, T. / Watanabe, S. / Inoue, M. / Hayashizaki, Y. / Tanaka, A. / Kigawa, T. / Yokoyama, S. |
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履歴 | 登録 | 2007年4月5日 | 登録サイト: PDBJ / 処理サイト: PDBJ |
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改定 1.0 | 2008年4月8日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2022年3月16日 | Group: Data collection / Database references / Derived calculations カテゴリ: database_2 / pdbx_nmr_software ...database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / pdbx_struct_assembly / pdbx_struct_oper_list / struct_ref_seq_dif Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _struct_ref_seq_dif.details |
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改定 1.3 | 2024年5月29日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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Remark 650 | HELIX Determination method: Author determined |
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Remark 700 | SHEET Determination method: Author determined |
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