+Open data
-Basic information
Entry | Database: PDB / ID: 2wnt | ||||||
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Title | Crystal Structure of the Human Ribosomal protein S6 kinase | ||||||
Components | RIBOSOMAL PROTEIN S6 KINASERibosomal s6 kinase | ||||||
Keywords | TRANSFERASE / ATP-BINDING / POLYMORPHISM / METAL-BINDING / HUMAN / KINASE / RIBOSOMAL / MAGNESIUM / SERINE/THREONINE-PROTEIN KINASE / PHOSPHOPROTEIN / NUCLEOTIDE-BINDING | ||||||
Function / homology | Function and homology information regulation of translation in response to stress / CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling / ribosomal protein S6 kinase activity / CREB phosphorylation / hepatocyte proliferation / positive regulation of hepatic stellate cell activation / Gastrin-CREB signalling pathway via PKC and MAPK / RSK activation / negative regulation of TOR signaling / ERK/MAPK targets ...regulation of translation in response to stress / CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling / ribosomal protein S6 kinase activity / CREB phosphorylation / hepatocyte proliferation / positive regulation of hepatic stellate cell activation / Gastrin-CREB signalling pathway via PKC and MAPK / RSK activation / negative regulation of TOR signaling / ERK/MAPK targets / Recycling pathway of L1 / cysteine-type endopeptidase inhibitor activity involved in apoptotic process / protein serine/threonine/tyrosine kinase activity / positive regulation of cell differentiation / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / Senescence-Associated Secretory Phenotype (SASP) / positive regulation of cell growth / chemical synaptic transmission / non-specific serine/threonine protein kinase / intracellular signal transduction / cell cycle / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / synapse / negative regulation of apoptotic process / positive regulation of DNA-templated transcription / magnesium ion binding / signal transduction / positive regulation of transcription by RNA polymerase II / nucleoplasm / ATP binding / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | HOMO SAPIENS (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.4 Å | ||||||
Authors | Muniz, J.R.C. / Elkins, J.M. / Wang, J. / Ugochukwu, E. / Salah, E. / King, O. / Picaud, S. / von Delft, F. / Bountra, C. / Arrowsmith, C.H. ...Muniz, J.R.C. / Elkins, J.M. / Wang, J. / Ugochukwu, E. / Salah, E. / King, O. / Picaud, S. / von Delft, F. / Bountra, C. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A. / Knapp, S. | ||||||
Citation | Journal: To be Published Title: Crystal Structure of the Human Ribosomal Protein S6 Kinase Authors: Muniz, J.R.C. / Elkins, J.M. / Wang, J. / Ugochukwu, E. / Salah, E. / King, O. / Picaud, S. / von Delft, F. / Bountra, C. / Arrowsmith, C.H. / Weigelt, J. / Edwards, A. / Knapp, S. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2wnt.cif.gz | 240.3 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2wnt.ent.gz | 202.6 KB | Display | PDB format |
PDBx/mmJSON format | 2wnt.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/wn/2wnt ftp://data.pdbj.org/pub/pdb/validation_reports/wn/2wnt | HTTPS FTP |
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-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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