登録情報 データベース : PDB / ID : 2w9f 構造の表示 ダウンロードとリンクタイトル Crystal Structure of CDK4 in complex with a D-type cyclin 要素CELL DIVISION PROTEIN KINASE 4 細胞分裂 G1/S-SPECIFIC CYCLIN-D1 詳細キーワード CELL CYCLE (細胞周期) / SERINE/THREONINE-PROTEIN KINASE / CHROMOSOMAL REARRANGEMENT / ATP-BINDING / TRANSFERASE (転移酵素) / POLYMORPHISM / CELL DIVISION (細胞分裂) / PROTO-ONCOGENE (がん遺伝子) / PHOSPHOPROTEIN / DISEASE MUTATION / NUCLEOTIDE-BINDING / CYCLIN DEPENDENT KINASE (サイクリン依存性キナーゼ) / KINASE (キナーゼ) / CYCLIN (サイクリン) / ONCOLOGY (腫瘍学) / DRUG DESGN機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
re-entry into mitotic cell cycle / cyclin D3-CDK4 complex / cyclin D1-CDK4 complex / cyclin D2-CDK4 complex / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 / cellular response to ionomycin / regulation of transcription initiation by RNA polymerase II / Drug-mediated inhibition of CDK4/CDK6 activity / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 ... re-entry into mitotic cell cycle / cyclin D3-CDK4 complex / cyclin D1-CDK4 complex / cyclin D2-CDK4 complex / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 / cellular response to ionomycin / regulation of transcription initiation by RNA polymerase II / Drug-mediated inhibition of CDK4/CDK6 activity / Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 / regulation of type B pancreatic cell proliferation / RUNX3 regulates WNT signaling / response to leptin / positive regulation of mammary gland epithelial cell proliferation / cellular response to phorbol 13-acetate 12-myristate / Transcriptional regulation by RUNX2 / mitotic cell cycle phase transition / cyclin-dependent protein serine/threonine kinase activator activity / proline-rich region binding / Regulation of RUNX1 Expression and Activity / cyclin-dependent protein serine/threonine kinase regulator activity / mammary gland epithelial cell proliferation / response to UV-A / negative regulation of epithelial cell differentiation / fat cell differentiation / PTK6 Regulates Cell Cycle / Defective binding of RB1 mutants to E2F1,(E2F2, E2F3) / RUNX3 regulates p14-ARF / positive regulation of cyclin-dependent protein serine/threonine kinase activity / Transcriptional Regulation by VENTX / Estrogen-dependent nuclear events downstream of ESR-membrane signaling / cyclin-dependent protein kinase holoenzyme complex / bicellular tight junction / mammary gland alveolus development / cellular response to interleukin-4 / サイクリン依存性キナーゼ / cyclin-dependent protein serine/threonine kinase activity / endoplasmic reticulum unfolded protein response / mitotic G1 DNA damage checkpoint signaling / regulation of G2/M transition of mitotic cell cycle / positive regulation of G2/M transition of mitotic cell cycle / 授乳 / transcription repressor complex / cyclin binding / : / Ubiquitin-dependent degradation of Cyclin D / liver regeneration / neuron differentiation / Oncogene Induced Senescence / G1/S transition of mitotic cell cycle / SCF(Skp2)-mediated degradation of p27/p21 / RMTs methylate histone arginines / 遺伝的組換え / Pre-NOTCH Transcription and Translation / Wntシグナル経路 / histone deacetylase binding / Transcriptional regulation of white adipocyte differentiation / Transcriptional regulation of granulopoiesis / transcription corepressor activity / Cyclin D associated events in G1 / positive regulation of fibroblast proliferation / Senescence-Associated Secretory Phenotype (SASP) / 遺伝子発現の調節 / 核膜 / Oxidative Stress Induced Senescence / Interleukin-4 and Interleukin-13 signaling / Estrogen-dependent gene expression / cellular response to lipopolysaccharide / negative regulation of neuron apoptotic process / transcription regulator complex / regulation of cell cycle / protein kinase activity / response to xenobiotic stimulus / positive regulation of protein phosphorylation / 細胞分裂 / protein phosphorylation / protein serine kinase activity / DNA damage response / クロマチン / positive regulation of cell population proliferation / 核小体 / protein kinase binding / enzyme binding / negative regulation of transcription by RNA polymerase II / シグナル伝達 / 核質 / ATP binding / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 Cyclin, C-terminal domain / : / Cyclins signature. / サイクリン / Cyclin, C-terminal domain / Cyclin_C / Cyclin-like / Cyclin A; domain 1 / Cyclin, N-terminal / Cyclin, N-terminal domain ... Cyclin, C-terminal domain / : / Cyclins signature. / サイクリン / Cyclin, C-terminal domain / Cyclin_C / Cyclin-like / Cyclin A; domain 1 / Cyclin, N-terminal / Cyclin, N-terminal domain / Cyclin-like / domain present in cyclins, TFIIB and Retinoblastoma / Cyclin-like superfamily / Transferase(Phosphotransferase) domain 1 / Transferase(Phosphotransferase); domain 1 / Phosphorylase Kinase; domain 1 / Phosphorylase Kinase; domain 1 / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / 2-Layer Sandwich / Orthogonal Bundle / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性生物種 HOMO SAPIENS (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.85 Å 詳細データ登録者 Day, P.J. / Cleasby, A. / Tickle, I.J. / Reilly, M.O. / Coyle, J.E. / Holding, F.P. / McMenamin, R.L. / Yon, J. / Chopra, R. / Lengauer, C. / Jhoti, H. 引用ジャーナル : Proc.Natl.Acad.Sci.USA / 年 : 2009タイトル : Crystal Structure of Human Cdk4 in Complex with a D-Type Cyclin.著者 : Day, P.J. / Cleasby, A. / Tickle, I.J. / O'Reilly, M. / Coyle, J.E. / Holding, F.P. / Mcmenamin, R.L. / Yon, J. / Chopra, R. / Lengauer, C. / Jhoti, H. 履歴 登録 2009年1月23日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2009年3月10日 Provider : repository / タイプ : Initial release改定 1.1 2011年5月8日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2019年4月24日 Group : Data collection / Other / Source and taxonomyカテゴリ : entity_src_gen / pdbx_database_proc / pdbx_database_statusItem : _entity_src_gen.pdbx_host_org_cell_line / _pdbx_database_status.recvd_author_approval改定 1.4 2023年12月13日 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
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