登録情報 | データベース: PDB / ID: 2rqh |
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タイトル | Structure of GSPT1/ERF3A-PABC |
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要素 | - G1 to S phase transition 1
- Polyadenylate-binding protein 1
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キーワード | PROTEIN BINDING (タンパク質) / PROTEIN-PROTEIN COMPLEX / GTP-binding / Nucleotide-binding / Alternative splicing (選択的スプライシング) / Cytoplasm (細胞質) / Methylation (メチル化) / mRNA processing (転写後修飾) / mRNA splicing / Nucleus (Nucleus) / Phosphoprotein / RNA-binding / Spliceosome (スプライセオソーム) |
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機能・相同性 | 機能・相同性情報
Eukaryotic Translation Termination / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / mCRD-mediated mRNA stability complex / translation release factor complex / translation activator activity / negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / CRD-mediated mRNA stabilization / regulation of translational termination ...Eukaryotic Translation Termination / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / mCRD-mediated mRNA stability complex / translation release factor complex / translation activator activity / negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / CRD-mediated mRNA stabilization / regulation of translational termination / translation release factor activity / Z-decay: degradation of maternal mRNAs by zygotically expressed factors / Deadenylation of mRNA / positive regulation of cytoplasmic translation / mRNA stabilization / poly(A) binding / M-decay: degradation of maternal mRNAs by maternally stored factors / regulatory ncRNA-mediated gene silencing / poly(U) RNA binding / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / positive regulation of nuclear-transcribed mRNA poly(A) tail shortening / Translation initiation complex formation / : / cell leading edge / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / L13a-mediated translational silencing of Ceruloplasmin expression / positive regulation of viral genome replication / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / translational termination / catalytic step 2 spliceosome / cytosolic ribosome / mRNA 3'-UTR binding / AUF1 (hnRNP D0) binds and destabilizes mRNA / 加水分解酵素; 酸無水物に作用; GTPに作用・細胞または細胞小器官の運動に関与 / cytoplasmic ribonucleoprotein granule / mRNA splicing, via spliceosome / Regulation of expression of SLITs and ROBOs / cytoplasmic stress granule / lamellipodium / ribonucleoprotein complex / 翻訳 (生物学) / focal adhesion / mRNA binding / GTPase activity / GTP binding / RNA binding / extracellular exosome / 生体膜 / 細胞核 / 細胞質基質 / 細胞質類似検索 - 分子機能 Ataxin-2, C-terminal / Ataxin-2 C-terminal region / c-terminal domain of poly(a) binding protein / c-terminal domain of poly(a) binding protein / : / PABP, RNA recognition motif 2 / Polyadenylate binding protein, human types 1, 2, 3, 4 / Polyadenylate-binding protein/Hyperplastic disc protein / Poly-adenylate binding protein, unique domain / Poly(A)-binding protein C-terminal (PABC) domain profile. ...Ataxin-2, C-terminal / Ataxin-2 C-terminal region / c-terminal domain of poly(a) binding protein / c-terminal domain of poly(a) binding protein / : / PABP, RNA recognition motif 2 / Polyadenylate binding protein, human types 1, 2, 3, 4 / Polyadenylate-binding protein/Hyperplastic disc protein / Poly-adenylate binding protein, unique domain / Poly(A)-binding protein C-terminal (PABC) domain profile. / C-terminal domain of Poly(A)-binding protein. Present also in Drosophila hyperplastics discs protein. / PABC (PABP) domain / RNA recognition motif domain, eukaryote / RNA認識モチーフ / Translation elongation factor EFTu/EF1A, C-terminal / Elongation factor Tu C-terminal domain / Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal / Tr-type G domain, conserved site / Translational (tr)-type guanine nucleotide-binding (G) domain signature. / Translation elongation factor EFTu-like, domain 2 / Elongation factor Tu domain 2 / Translational (tr)-type GTP-binding domain / Elongation factor Tu GTP binding domain / Translational (tr)-type guanine nucleotide-binding (G) domain profile. / RNA認識モチーフ / RNA認識モチーフ / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Translation protein, beta-barrel domain superfamily / Nucleotide-binding alpha-beta plait domain superfamily / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Polyadenylate-binding protein 1 / Eukaryotic peptide chain release factor GTP-binding subunit ERF3A / Eukaryotic peptide chain release factor GTP-binding subunit ERF3A類似検索 - 構成要素 |
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生物種 | Mus musculus (ハツカネズミ) Homo sapiens (ヒト) |
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手法 | 溶液NMR / torsion angle dynamics |
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Model details | lowest energy, model 1 |
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データ登録者 | Osawa, M. / Nakanishi, T. / Hosoda, N. / Uchida, S. / Hoshino, T. / Katada, I. / Shimada, I. |
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引用 | ジャーナル: To be Published タイトル: Eukaryotic Translation Termination Factor Gspt/Erf3 Recognizes Pabp with Chemical Exchange Using Two Overlapping Motifs 著者: Osawa, M. / Nakanishi, T. / Hosoda, N. / Uchida, S. / Hoshino, T. / Katada, I. / Shimada, I. |
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履歴 | 登録 | 2009年5月8日 | 登録サイト: BMRB / 処理サイト: PDBJ |
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改定 1.0 | 2010年5月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2011年7月13日 | Group: Version format compliance |
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改定 1.2 | 2024年5月1日 | Group: Data collection / Database references カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model |
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