- PDB-2mls: Membrane Bilayer complex with Matrix Metalloproteinase-12 at its ... -
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ID or keywords:
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Basic information
Entry
Database: PDB / ID: 2mls
Title
Membrane Bilayer complex with Matrix Metalloproteinase-12 at its Beta-face
Components
Macrophage metalloelastase
Keywords
HYDROLASE / Membrane-binding of soluble metalloproteinase MMP-12 / Catalytic domain
Function / homology
Function and homology information
macrophage elastase / negative regulation of endothelial cell-matrix adhesion via fibronectin / bronchiole development / positive regulation of epithelial cell proliferation involved in wound healing / elastin catabolic process / regulation of defense response to virus by host / positive regulation of type I interferon-mediated signaling pathway / wound healing, spreading of epidermal cells / negative regulation of type I interferon-mediated signaling pathway / lung alveolus development ...macrophage elastase / negative regulation of endothelial cell-matrix adhesion via fibronectin / bronchiole development / positive regulation of epithelial cell proliferation involved in wound healing / elastin catabolic process / regulation of defense response to virus by host / positive regulation of type I interferon-mediated signaling pathway / wound healing, spreading of epidermal cells / negative regulation of type I interferon-mediated signaling pathway / lung alveolus development / response to amyloid-beta / Collagen degradation / collagen catabolic process / extracellular matrix disassembly / positive regulation of interferon-alpha production / core promoter sequence-specific DNA binding / collagen binding / Degradation of the extracellular matrix / extracellular matrix organization / extracellular matrix / metalloendopeptidase activity / cellular response to virus / protein import into nucleus / endopeptidase activity / sequence-specific DNA binding / serine-type endopeptidase activity / calcium ion binding / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / proteolysis / extracellular space / zinc ion binding / extracellular region / nucleus / cytoplasm Similarity search - Function
Type: Bruker AVANCE II / Manufacturer: Bruker / Model: AVANCE II / Field strength: 800 MHz
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Processing
NMR software
Name
Developer
Classification
Sparky
Goddard
dataanalysis
GROMACS
BERENDSEN
refinement
Refinement
Method: molecular dynamics / Software ordinal: 1 Details: Temperature equilibration(NVT) for 200ps and NPT(pressure) equilibration for 1ns followed by production MD 15ns.
NMR representative
Selection criteria: lowest energy
NMR ensemble
Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 14 / Conformers submitted total number: 14
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