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Yorodumi- PDB-2lm5: Solution structure of Ca2+-CIB1 in complex with the cytoplasmic d... -
+Open data
-Basic information
Entry | Database: PDB / ID: 2lm5 | ||||||
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Title | Solution structure of Ca2+-CIB1 in complex with the cytoplasmic domain of the integrin aIIb subunit | ||||||
Components | Calcium and integrin-binding protein 1 | ||||||
Keywords | METAL BINDING PROTEIN | ||||||
Function / homology | Function and homology information calcium-dependent protein kinase inhibitor activity / thrombopoietin-mediated signaling pathway / endomitotic cell cycle / positive regulation of male germ cell proliferation / filopodium tip / positive regulation of calcineurin-NFAT signaling cascade / negative regulation of microtubule depolymerization / protein serine/threonine kinase inhibitor activity / positive regulation of cell adhesion mediated by integrin / positive regulation of cell-matrix adhesion ...calcium-dependent protein kinase inhibitor activity / thrombopoietin-mediated signaling pathway / endomitotic cell cycle / positive regulation of male germ cell proliferation / filopodium tip / positive regulation of calcineurin-NFAT signaling cascade / negative regulation of microtubule depolymerization / protein serine/threonine kinase inhibitor activity / positive regulation of cell adhesion mediated by integrin / positive regulation of cell-matrix adhesion / platelet formation / positive regulation of cell migration involved in sprouting angiogenesis / positive regulation of catalytic activity / regulation of cell division / spermatid development / positive regulation of protein targeting to membrane / negative regulation of megakaryocyte differentiation / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of substrate adhesion-dependent cell spreading / cytoplasmic microtubule organization / extrinsic apoptotic signaling pathway / protein-membrane adaptor activity / cellular response to nerve growth factor stimulus / negative regulation of protein phosphorylation / cell periphery / response to ischemia / positive regulation of protein localization to plasma membrane / positive regulation of protein serine/threonine kinase activity / sarcolemma / cellular response to growth factor stimulus / small GTPase binding / ruffle membrane / double-strand break repair / lamellipodium / negative regulation of neuron projection development / cellular response to tumor necrosis factor / positive regulation of NF-kappaB transcription factor activity / regulation of cell population proliferation / growth cone / positive regulation of cell growth / perikaryon / angiogenesis / vesicle / transmembrane transporter binding / positive regulation of ERK1 and ERK2 cascade / cell adhesion / positive regulation of cell migration / neuron projection / apical plasma membrane / positive regulation of protein phosphorylation / negative regulation of cell population proliferation / axon / cell division / centrosome / neuronal cell body / apoptotic process / DNA damage response / calcium ion binding / positive regulation of cell population proliferation / negative regulation of apoptotic process / perinuclear region of cytoplasm / Golgi apparatus / magnesium ion binding / endoplasmic reticulum / extracellular exosome / nucleoplasm / membrane / nucleus / plasma membrane / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR / simulated annealing | ||||||
Model details | lowest energy, model 2 | ||||||
Authors | Huang, H. / Vogel, H.J. | ||||||
Citation | Journal: J.Am.Chem.Soc. / Year: 2012 Title: Structural basis for the activation of platelet integrin alphaIIb-beta3 by calcium- and integrin-binding protein 1. Authors: Huang, H. / Vogel, H.J. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2lm5.cif.gz | 580.3 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2lm5.ent.gz | 479.5 KB | Display | PDB format |
PDBx/mmJSON format | 2lm5.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/lm/2lm5 ftp://data.pdbj.org/pub/pdb/validation_reports/lm/2lm5 | HTTPS FTP |
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-Related structure data
Related structure data | |
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Similar structure data | |
Other databases |
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 24507.264 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: CIB1, CIB, KIP, PRKDCIP / Production host: Escherichia coli (E. coli) / References: UniProt: Q99828 |
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#2: Chemical |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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-Sample preparation
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