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Yorodumi- PDB-2l9r: Solution NMR Structure of Homeobox domain of Homeobox protein Nkx... -
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-Basic information
Entry | Database: PDB / ID: 2l9r | ||||||
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Title | Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A | ||||||
Components | Homeobox protein Nkx-3.1 | ||||||
Keywords | TRANSCRIPTION / Structural Genomics / NORTHEAST STRUCTURAL GENOMICS CONSORTIUM / NESG / PSI-Biology / Protein Structure Initiative / transcription factor / Methods Development | ||||||
Function / homology | Function and homology information : / MADS box domain binding / positive regulation of androgen secretion / regulation of cell cycle => GO:0051726 / salivary gland development / : / dorsal aorta development / : / cellular response to xenobiotic stimulus => GO:0071466 / : ...: / MADS box domain binding / positive regulation of androgen secretion / regulation of cell cycle => GO:0051726 / salivary gland development / : / dorsal aorta development / : / cellular response to xenobiotic stimulus => GO:0071466 / : / negative regulation of insulin-like growth factor receptor signaling pathway / negative regulation of epithelial cell proliferation involved in prostate gland development / multicellular organism development / chromatin => GO:0000785 / epithelial cell proliferation involved in salivary gland morphogenesis / branching involved in prostate gland morphogenesis / pharyngeal system development / metanephros development / cellular response to steroid hormone stimulus / branching morphogenesis of an epithelial tube / response to testosterone / nuclear estrogen receptor activity / androgen receptor signaling pathway / site of DNA damage / cysteine-type endopeptidase activator activity involved in apoptotic process / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / transcription factor binding / positive regulation of cell division / negative regulation of mitotic cell cycle / cellular response to interleukin-1 / somitogenesis / positive regulation of intrinsic apoptotic signaling pathway / positive regulation of apoptotic signaling pathway / positive regulation of mitotic cell cycle / phosphatidylinositol 3-kinase/protein kinase B signal transduction / nuclear estrogen receptor binding / histone deacetylase binding / male gonad development / activation of cysteine-type endopeptidase activity involved in apoptotic process / nuclear receptor activity / : / regulation of protein localization / positive regulation of DNA-binding transcription factor activity / negative regulation of epithelial cell proliferation / sequence-specific double-stranded DNA binding / cellular response to tumor necrosis factor / heart development / cellular response to hypoxia / sequence-specific DNA binding / cell differentiation / transcription cis-regulatory region binding / DNA-binding transcription factor activity, RNA polymerase II-specific / positive regulation of protein phosphorylation / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of cell population proliferation / negative regulation of gene expression / negative regulation of DNA-templated transcription / positive regulation of cell population proliferation / positive regulation of gene expression / regulation of DNA-templated transcription / positive regulation of DNA-templated transcription / positive regulation of transcription by RNA polymerase II / nucleoplasm / nucleus / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR / distance geometry, torsion angle dynamics, molecular dynamics | ||||||
Model details | lowest energy, model 1 | ||||||
Authors | Liu, G. / Xiao, R. / Lee, H.-W. / Hamilton, K. / Ciccosanti, C. / Wang, H.B. / Acton, T.B. / Everett, J.K. / Huang, Y.J. / Montelione, G.T. / Northeast Structural Genomics Consortium (NESG) | ||||||
Citation | Journal: To be Published Title: Solution NMR Structure of Homeobox domain of Homeobox protein Nkx-3.1 from homo sapiens, Northeast Structural Genomics Consortium Target HR6470A Authors: Liu, G. / Xiao, R. / Lee, H.-W. / Hamilton, K. / Ciccosanti, C. / Wang, H.B. / Acton, T.B. / Everett, J.K. / Huang, Y.J. / Montelione, G.T. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2l9r.cif.gz | 529.6 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2l9r.ent.gz | 453 KB | Display | PDB format |
PDBx/mmJSON format | 2l9r.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/l9/2l9r ftp://data.pdbj.org/pub/pdb/validation_reports/l9/2l9r | HTTPS FTP |
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-Related structure data
Similar structure data | |
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Other databases |
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 8370.620 Da / Num. of mol.: 1 / Fragment: DNA binding Homeobox residues 132-189 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: NKX3-1, NKX3.1, NKX3A / Production host: Escherichia coli (E. coli) / References: UniProt: Q99801 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||
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NMR experiment |
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-Sample preparation
Details |
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Sample |
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Sample conditions | pH: 6.5 / Pressure: ambient / Temperature: 298 K |
-NMR measurement
NMR spectrometer |
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-Processing
NMR software |
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