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Yorodumi- PDB-2l1x: The Solution Structure Of Human Parathyroid Hormone-Related Protein -
+Open data
-Basic information
Entry | Database: PDB / ID: 2l1x | ||||||
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Title | The Solution Structure Of Human Parathyroid Hormone-Related Protein | ||||||
Components | Parathyroid hormone | ||||||
Keywords | HORMONE / PTHrP | ||||||
Function / homology | Function and homology information type 1 parathyroid hormone receptor binding / parathyroid hormone receptor binding / negative regulation of bone mineralization involved in bone maturation / positive regulation of osteoclast proliferation / negative regulation of apoptotic process in bone marrow cell / hormone-mediated apoptotic signaling pathway / response to parathyroid hormone / positive regulation of cell proliferation in bone marrow / magnesium ion homeostasis / positive regulation of signal transduction ...type 1 parathyroid hormone receptor binding / parathyroid hormone receptor binding / negative regulation of bone mineralization involved in bone maturation / positive regulation of osteoclast proliferation / negative regulation of apoptotic process in bone marrow cell / hormone-mediated apoptotic signaling pathway / response to parathyroid hormone / positive regulation of cell proliferation in bone marrow / magnesium ion homeostasis / positive regulation of signal transduction / macromolecule biosynthetic process / response to fibroblast growth factor / phosphate ion homeostasis / cAMP metabolic process / response to vitamin D / negative regulation of chondrocyte differentiation / Class B/2 (Secretin family receptors) / positive regulation of inositol phosphate biosynthetic process / peptide hormone receptor binding / bone mineralization / Rho protein signal transduction / : / positive regulation of glycogen biosynthetic process / positive regulation of bone mineralization / response to cadmium ion / homeostasis of number of cells within a tissue / bone resorption / skeletal system development / positive regulation of glucose import / response to lead ion / adenylate cyclase-activating G protein-coupled receptor signaling pathway / hormone activity / intracellular calcium ion homeostasis / cell-cell signaling / G alpha (s) signalling events / regulation of gene expression / response to ethanol / transcription by RNA polymerase II / receptor ligand activity / response to xenobiotic stimulus / G protein-coupled receptor signaling pathway / negative regulation of gene expression / positive regulation of gene expression / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR / molecular dynamics | ||||||
Model details | lowest energy, model 1 | ||||||
Authors | Lin, K. / You, Q. / Lin, D. / Liu, J. | ||||||
Citation | Journal: To be Published Title: The Solution Structure Of Human Parathyroid Hormone-Related Protein Authors: Lin, K. / Lin, D. / You, Q. / Liu, J. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2l1x.cif.gz | 150.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2l1x.ent.gz | 124.6 KB | Display | PDB format |
PDBx/mmJSON format | 2l1x.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/l1/2l1x ftp://data.pdbj.org/pub/pdb/validation_reports/l1/2l1x | HTTPS FTP |
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-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein/peptide | Mass: 4673.360 Da / Num. of mol.: 1 / Fragment: UNP rresidues 32-65 / Mutation: L13R Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: PTH / Production host: Escherichia coli (E. coli) / References: UniProt: P01270 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR Details: The Solution Structure Of Human Parathyroid Hormone-Related Protein | ||||||||||||
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NMR experiment |
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-Sample preparation
Details | Contents: 2.5 mM dpth-1, 90% H2O/10% D2O / Solvent system: 90% H2O/10% D2O |
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Sample | Conc.: 2.5 mM / Component: dpth-1 |
Sample conditions | Ionic strength: 50 / pH: 7 / Pressure: ambient / Temperature: 298 K |
-NMR measurement
NMR spectrometer | Type: Varian Unity / Manufacturer: Varian / Model: UNITY / Field strength: 600 MHz |
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-Processing
NMR software |
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Refinement | Method: molecular dynamics / Software ordinal: 1 | ||||||||||||
NMR representative | Selection criteria: lowest energy | ||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 200 / Conformers submitted total number: 10 / Representative conformer: 1 |