登録情報 データベース : PDB / ID : 2kyl 構造の表示 ダウンロードとリンクタイトル Solution structure of MAST2-PDZ complexed with the C-terminus of PTEN 要素C-terminus of Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN Microtubule-associated serine/threonine-protein kinase 2 詳細キーワード TRANSFERASE (転移酵素) / PDZ / complex / kinase (キナーゼ)機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity / PTEN Loss of Function in Cancer / phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase / regulation of cellular component size / negative regulation of keratinocyte migration / phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity / negative regulation of synaptic vesicle clustering / phosphatidylinositol phosphate phosphatase activity / rhythmic synaptic transmission / inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity ... inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity / PTEN Loss of Function in Cancer / phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase / regulation of cellular component size / negative regulation of keratinocyte migration / phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity / negative regulation of synaptic vesicle clustering / phosphatidylinositol phosphate phosphatase activity / rhythmic synaptic transmission / inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity / central nervous system myelin maintenance / negative regulation of wound healing, spreading of epidermal cells / phosphatidylinositol-3-phosphate phosphatase activity / central nervous system neuron axonogenesis / postsynaptic density assembly / neuron-neuron synaptic transmission / spermatid differentiation / negative regulation of dendritic spine morphogenesis / Regulation of PTEN mRNA translation / synapse maturation / presynaptic membrane assembly / Negative regulation of the PI3K/AKT network / cellular response to electrical stimulus / negative regulation of cell cycle G1/S phase transition / negative regulation of axonogenesis / Transcriptional Regulation by MECP2 / myelin sheath adaxonal region / phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity / negative regulation of excitatory postsynaptic potential / negative regulation of organ growth / forebrain morphogenesis / negative regulation of focal adhesion assembly / Schmidt-Lanterman incisure / anaphase-promoting complex binding / 加水分解酵素; エステル加水分解酵素; 1価のリン酸エステル加水分解酵素 / phosphatidylinositol dephosphorylation / dentate gyrus development / negative regulation of cyclin-dependent protein serine/threonine kinase activity / positive regulation of ubiquitin protein ligase activity / spindle assembly involved in female meiosis / positive regulation of ubiquitin-dependent protein catabolic process / negative regulation of epithelial to mesenchymal transition / negative regulation of cell size / phosphatidylinositol biosynthetic process / dendritic spine morphogenesis / regulation of interleukin-12 production / brain morphogenesis / regulation of neuron projection development / myosin phosphatase activity / negative regulation of G1/S transition of mitotic cell cycle / protein serine/threonine phosphatase activity / molecular function inhibitor activity / ubiquitin-specific protease binding / protein-serine/threonine phosphatase / regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / Synthesis of IP3 and IP4 in the cytosol / locomotor rhythm / negative regulation of vascular associated smooth muscle cell proliferation / negative regulation of cellular senescence / social behavior / phosphoprotein phosphatase activity / Synthesis of PIPs at the plasma membrane / positive regulation of excitatory postsynaptic potential / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / canonical Wnt signaling pathway / phosphatase binding / localization / prepulse inhibition / multicellular organismal response to stress / negative regulation of peptidyl-serine phosphorylation / synapse assembly / cytoskeleton organization / Regulation of PTEN localization / protein dephosphorylation / negative regulation of cell migration / プロテインチロシンホスファターゼ / phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of protein phosphorylation / locomotory behavior / central nervous system development / protein tyrosine phosphatase activity / cell projection / PDZ domain binding / 運動性 / TP53 Regulates Metabolic Genes / regulation of protein stability / cytoplasmic side of plasma membrane / PML body / positive regulation of DNA-binding transcription factor activity / Regulation of PTEN stability and activity / microtubule cytoskeleton / Ovarian tumor domain proteases / 遊走 / Downstream TCR signaling / negative regulation of neuron projection development / heart development / microtubule binding / 樹状突起スパイン / postsynaptic density / learning or memory 類似検索 - 分子機能 Microtubule-associated serine/threonine-protein kinase, domain / Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily / Microtubule-associated serine/threonine-protein kinase, catalytic domain / Domain of unknown function (DUF1908) / PTEN, phosphatase domain / Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN / フィチン酸 / Tensin phosphatase, C2 domain / Tensin-type phosphatase domain / C2 domain of PTEN tumour-suppressor protein ... Microtubule-associated serine/threonine-protein kinase, domain / Microtubule-associated serine/threonine-protein kinase, pre-PK domain superfamily / Microtubule-associated serine/threonine-protein kinase, catalytic domain / Domain of unknown function (DUF1908) / PTEN, phosphatase domain / Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN / フィチン酸 / Tensin phosphatase, C2 domain / Tensin-type phosphatase domain / C2 domain of PTEN tumour-suppressor protein / Phosphatase tensin-type domain profile. / C2 tensin-type domain profile. / C2 domain of PTEN tumour-suppressor protein / PDZ domain 6 / PDZドメイン / PDZドメイン / Pdz3 Domain / AGC-kinase, C-terminal / AGC-kinase C-terminal domain profile. / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Protein-tyrosine phosphatase, active site / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / C2 domain superfamily / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZドメイン / PDZ superfamily / Roll / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Mainly Beta 類似検索 - ドメイン・相同性 Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN / Microtubule-associated serine/threonine-protein kinase 2 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 溶液NMR / torsion angle dynamics 詳細Model details lowest energy, model 1 データ登録者 Terrien, E. / Wolff, N. / Cordier, F. / Simenel, C. / Lafon, M. / Delepierre, M. 引用ジャーナル : To be Published タイトル : Solution structure of MAST2-PDZ complexed with the C-terminus of PTEN著者 : Terrien, E. / Wolff, N. / Cordier, F. / Simenel, C. / Lafon, M. / Prehaud, C. / Delepierre, M. 履歴 登録 2010年6月1日 登録サイト : BMRB / 処理サイト : PDBJ改定 1.0 2011年6月8日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2020年2月26日 Group : Data collection / Database references / Otherカテゴリ : database_2 / pdbx_database_status ... database_2 / pdbx_database_status / pdbx_nmr_software / struct_ref_seq_dif Item : _pdbx_database_status.status_code_cs / _pdbx_nmr_software.name / _struct_ref_seq_dif.details改定 1.3 2023年6月14日 Group : Database references / Other / カテゴリ : database_2 / pdbx_database_statusItem : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_nmr_data改定 1.4 2024年5月15日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2 / Item : _database_2.pdbx_DOI
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