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Yorodumi- PDB-2jx4: NMR structure of the intracellular loop (i3) of the vasopressin V... -
+Open data
-Basic information
Entry | Database: PDB / ID: 2jx4 | ||||||
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Title | NMR structure of the intracellular loop (i3) of the vasopressin V2 receptor (GPCR) | ||||||
Components | Vasopressin V2 receptorVasopressin receptor 2 | ||||||
Keywords | MEMBRANE PROTEIN / protein / G-protein coupled receptor / Glycoprotein / Lipoprotein / Membrane / Palmitate / Phosphorylation / Receptor / Transducer / Transmembrane | ||||||
Function / homology | Function and homology information Vasopressin-like receptors / type II interferon production / negative regulation of renal sodium excretion / regulation of systemic arterial blood pressure by vasopressin / vasopressin receptor activity / negative regulation of urine volume / positive regulation of systemic arterial blood pressure / telencephalon development / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis ...Vasopressin-like receptors / type II interferon production / negative regulation of renal sodium excretion / regulation of systemic arterial blood pressure by vasopressin / vasopressin receptor activity / negative regulation of urine volume / positive regulation of systemic arterial blood pressure / telencephalon development / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / positive regulation of blood pressure / Vasopressin regulates renal water homeostasis via Aquaporins / plasma membrane => GO:0005886 / peptide hormone binding / endocytic vesicle / canonical NF-kappaB signal transduction / positive regulation of vasoconstriction / response to cytokine / G protein-coupled receptor activity / peptide binding / membrane => GO:0016020 / endosome / G protein-coupled receptor signaling pathway / negative regulation of cell population proliferation / positive regulation of cell population proliferation / positive regulation of gene expression / perinuclear region of cytoplasm / plasma membrane Similarity search - Function | ||||||
Method | SOLUTION NMR / torsion angle dynamics | ||||||
Authors | Bellot, G. / Demene, H. | ||||||
Citation | Journal: To be Published Title: Structure of the third intracellular loop of the vasopressin V2 receptor and conformational changes upon binding to gC1qR Authors: Bellot, G. / Granier, S. / Bourguet, W. / Seyer, R. / Rahmeh, R. / Mouillac, B. / Pascal, R. / Mendre, C. / Demene, H. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 2jx4.cif.gz | 340 KB | Display | PDBx/mmCIF format |
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PDB format | pdb2jx4.ent.gz | 297.9 KB | Display | PDB format |
PDBx/mmJSON format | 2jx4.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/jx/2jx4 ftp://data.pdbj.org/pub/pdb/validation_reports/jx/2jx4 | HTTPS FTP |
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-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 5534.353 Da / Num. of mol.: 1 / Fragment: residues 225-273 / Mutation: M266NLE,M272NLE / Source method: obtained synthetically Details: The peptide was chemically synthesized. The source sequence is naturally found in rat (v2 rat receptor). References: UniProt: Q00788 |
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Sequence details | THESE ARE LINKER. THIO-ETHER BRIDGE BETWEEN CCS AND GLY WERE CONSTRUCTE |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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-Sample preparation
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Sample |
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Sample conditions |
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-NMR measurement
NMR spectrometer |
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-Processing
NMR software |
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Refinement | Method: torsion angle dynamics / Software ordinal: 1 | ||||||||||||
NMR representative | Selection criteria: closest to the average | ||||||||||||
NMR ensemble | Conformer selection criteria: structures with the lowest energy Conformers calculated total number: 800 / Conformers submitted total number: 20 |