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Open data
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Basic information
Entry | Database: PDB / ID: 2hz0 | ||||||
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Title | Abl kinase domain in complex with NVP-AEG082 | ||||||
![]() | Proto-oncogene tyrosine-protein kinase ABL1 | ||||||
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Function / homology | ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Cowan-Jacob, S.W. / Fendrich, G. / Liebetanz, J. / Fabbro, D. / Manley, P. | ||||||
![]() | ![]() Title: Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia. Authors: Cowan-Jacob, S.W. / Fendrich, G. / Floersheimer, A. / Furet, P. / Liebetanz, J. / Rummel, G. / Rheinberger, P. / Centeleghe, M. / Fabbro, D. / Manley, P.W. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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Download
PDBx/mmCIF format | ![]() | 125.3 KB | Display | ![]() |
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PDB format | ![]() | 96.6 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 2hyyC ![]() 2hz4C ![]() 2hziC ![]() 2hznC ![]() 1fpuS C: citing same article ( S: Starting model for refinement |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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2 | ![]()
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Unit cell |
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Components
#1: Protein | Mass: 31333.963 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() References: UniProt: P00519, ![]() #2: Chemical | #3: Water | ChemComp-HOH / | ![]() |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2.35 Å3/Da / Density % sol: 47.6 % |
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Crystal grow![]() | Temperature: 293 K / Method: vapor diffusion, hanging drop Details: 28 % PEG 4000, 0.1 M Tris.HCl pH 8.0, 0.2 M NaAcetate, VAPOR DIFFUSION, HANGING DROP, temperature 293K |
-Data collection
Diffraction | Mean temperature: 100 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: MAR scanner 345 mm plate / Detector: IMAGE PLATE / Date: Mar 28, 2001 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength![]() |
Reflection | Resolution: 2.1→25 Å / Num. obs: 35534 / % possible obs: 99.8 % / Rmerge(I) obs: 0.087 / Χ2: 1.022 / Net I/σ(I): 6.6 |
Reflection shell | Resolution: 2.1→2.18 Å / Rmerge(I) obs: 0.267 / Num. unique all: 3487 / Χ2: 0.831 / % possible all: 99.9 |
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Processing
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Refinement | Method to determine structure![]() ![]() Starting model: 1FPU Resolution: 2.1→25 Å / σ(F): 0 / Stereochemistry target values: Engh & Huber
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Displacement parameters | Biso mean: 31.105 Å2 | ||||||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 2.1→25 Å
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Refine LS restraints |
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LS refinement shell | Resolution: 2.1→2.18 Å /
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