登録情報 | データベース: PDB / ID: 2b1w |
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タイトル | Solution structure of the NOD1 Caspase Activating and Recruitment Domain |
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要素 | Caspase recruitment domain protein 4 CARD domain |
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キーワード | APOPTOSIS (アポトーシス) / CARD4 / six-helix bundle / Caspase recruitment domain / inflammation (炎症) / NF-kB (NF-κB) / greek key |
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機能・相同性 | 機能・相同性情報
positive regulation of dendritic cell antigen processing and presentation / detection of biotic stimulus / positive regulation of xenophagy / xenophagy / nucleotide-binding oligomerization domain containing 1 signaling pathway / cellular response to muramyl dipeptide / CARD domain binding / peptidoglycan binding / positive regulation of macrophage cytokine production / pattern recognition receptor activity ...positive regulation of dendritic cell antigen processing and presentation / detection of biotic stimulus / positive regulation of xenophagy / xenophagy / nucleotide-binding oligomerization domain containing 1 signaling pathway / cellular response to muramyl dipeptide / CARD domain binding / peptidoglycan binding / positive regulation of macrophage cytokine production / pattern recognition receptor activity / pattern recognition receptor signaling pathway / cysteine-type endopeptidase activator activity involved in apoptotic process / positive regulation of cysteine-type endopeptidase activity involved in apoptotic process / detection of bacterium / JNK cascade / phagocytic vesicle / ERK1 and ERK2 cascade / response to endoplasmic reticulum stress / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / ubiquitin binding / positive regulation of interleukin-1 beta production / activated TAK1 mediates p38 MAPK activation / positive regulation of interleukin-8 production / positive regulation of JNK cascade / TAK1-dependent IKK and NF-kappa-B activation / NOD1/2 Signaling Pathway / defense response / Interleukin-1 signaling / positive regulation of non-canonical NF-kappaB signal transduction / positive regulation of interleukin-6 production / activation of cysteine-type endopeptidase activity involved in apoptotic process / positive regulation of tumor necrosis factor production / Ovarian tumor domain proteases / positive regulation of NF-kappaB transcription factor activity / basolateral plasma membrane / positive regulation of canonical NF-kappaB signal transduction / defense response to Gram-negative bacterium / positive regulation of ERK1 and ERK2 cascade / intracellular signal transduction / defense response to Gram-positive bacterium / defense response to bacterium / 炎症 / apical plasma membrane / positive regulation of apoptotic process / 自然免疫系 / apoptotic process / protein-containing complex binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / シグナル伝達 / protein homodimerization activity / ATP binding / identical protein binding / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 NACHT, LRR and PYD domains-containing protein, helical domain HD2 / NLRC4 helical domain HD2 / NOD2, winged helix domain / NOD2 winged helix domain / NACHT nucleoside triphosphatase / NACHT domain / NACHT-NTPase domain profile. / Death Domain, Fas / Death Domain, Fas / Leucine rich repeat, ribonuclease inhibitor type ...NACHT, LRR and PYD domains-containing protein, helical domain HD2 / NLRC4 helical domain HD2 / NOD2, winged helix domain / NOD2 winged helix domain / NACHT nucleoside triphosphatase / NACHT domain / NACHT-NTPase domain profile. / Death Domain, Fas / Death Domain, Fas / Leucine rich repeat, ribonuclease inhibitor type / ロイシンリッチリピート / CARD domain / CARD caspase recruitment domain profile. / Caspase recruitment domain / Death-like domain superfamily / ロイシンリッチリピート / Leucine-rich repeat domain superfamily / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 Nucleotide-binding oligomerization domain-containing protein 1類似検索 - 構成要素 |
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生物種 | ![](img/tx_human.gif) Homo sapiens (ヒト) |
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手法 | 溶液NMR / simulated annealing, torsion angle dynamics, refinement in explicit water |
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データ登録者 | Manon, F. / Favier, A. / Simorre, J.P. / Cusack, S. |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2007 タイトル: Solution structure of NOD1 CARD and mutational analysis of its interaction with the CARD of downstream kinase RICK. 著者: Manon, F. / Favier, A. / Nunez, G. / Simorre, J.P. / Cusack, S. |
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履歴 | 登録 | 2005年9月16日 | 登録サイト: RCSB / 処理サイト: PDBJ |
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改定 1.0 | 2006年9月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年5月1日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2011年10月5日 | Group: Database references / Other |
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改定 1.4 | 2020年2月26日 | Group: Database references / Other カテゴリ: database_2 / pdbx_database_status / struct_ref_seq_dif Item: _pdbx_database_status.status_code_cs / _struct_ref_seq_dif.details |
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改定 1.5 | 2024年5月1日 | Group: Data collection / Database references / カテゴリ: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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