登録情報 | データベース: PDB / ID: 2ar5 |
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タイトル | Crystal structure of the mammalian C2alpha-PI3 Kinase PX-domain |
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要素 | Phosphoinositide 3-kinasePI3キナーゼ |
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キーワード | TRANSFERASE (転移酵素) / PX domain |
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機能・相同性 | 機能・相同性情報
: / : / vascular associated smooth muscle contraction / Synthesis of PIPs at the late endosome membrane / Synthesis of PIPs at the early endosome membrane / Synthesis of PIPs at the Golgi membrane / clathrin coat assembly / phosphatidylinositol-4-phosphate 3-kinase / phosphatidylinositol kinase activity / membrane organization ...: / : / vascular associated smooth muscle contraction / Synthesis of PIPs at the late endosome membrane / Synthesis of PIPs at the early endosome membrane / Synthesis of PIPs at the Golgi membrane / clathrin coat assembly / phosphatidylinositol-4-phosphate 3-kinase / phosphatidylinositol kinase activity / membrane organization / phosphatidylinositol biosynthetic process / phosphatidylinositol 3-kinase complex / 1-phosphatidylinositol-4-phosphate 3-kinase activity / 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity / phosphatidylinositol-4,5-bisphosphate 3-kinase / クラスリン / PI3キナーゼ / phosphatidylinositol-3-phosphate biosynthetic process / clathrin binding / 1-phosphatidylinositol-3-kinase activity / positive regulation of cell migration involved in sprouting angiogenesis / Golgi Associated Vesicle Biogenesis / エキソサイトーシス / phosphatidylinositol phosphate biosynthetic process / phosphatidylinositol-mediated signaling / Synthesis of PIPs at the plasma membrane / platelet-derived growth factor receptor signaling pathway / positive regulation of autophagy / phosphatidylinositol binding / ゴルジ体 / epidermal growth factor receptor signaling pathway / エンドサイトーシス / 遊走 / insulin receptor signaling pathway / Clathrin-mediated endocytosis / vesicle / リン酸化 / intracellular membrane-bounded organelle / ゴルジ体 / extracellular exosome / 核質 / ATP binding / 生体膜 / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 PI3K-C2-alpha, catalytic domain / Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain / Phox-like domain / PX Domain / PhoX homologous domain, present in p47phox and p40phox. / PX domain profile. / PX domain / Phox homology / PX domain superfamily / PI3-kinase family, Ras-binding domain ...PI3K-C2-alpha, catalytic domain / Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain / Phox-like domain / PX Domain / PhoX homologous domain, present in p47phox and p40phox. / PX domain profile. / PX domain / Phox homology / PX domain superfamily / PI3-kinase family, Ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain / PI3-kinase family, ras-binding domain / Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain profile. / Phosphoinositide 3-kinase C2 / Phosphoinositide 3-kinase, region postulated to contain C2 domain / C2 phosphatidylinositol 3-kinase-type domain / C2 phosphatidylinositol 3-kinase (PI3K)-type domain profile. / Phosphoinositide 3-kinase, accessory (PIK) domain superfamily / Phosphoinositide 3-kinase family, accessory domain (PIK domain) / Phosphoinositide 3-kinase family, accessory domain (PIK domain) / Phosphoinositide 3-kinase, accessory (PIK) domain / Phosphatidylinositol kinase / PIK helical domain profile. / C2ドメイン / Protein kinase C conserved region 2 (CalB) / C2ドメイン / C2 domain profile. / Phosphatidylinositol 3- and 4-kinases signature 1. / Phosphatidylinositol 3/4-kinase, conserved site / Phosphatidylinositol 3- and 4-kinases signature 2. / Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily / Phosphoinositide 3-kinase, catalytic domain / Phosphatidylinositol 3- and 4-kinase / Phosphatidylinositol 3- and 4-kinases catalytic domain profile. / Phosphatidylinositol 3-/4-kinase, catalytic domain / C2 domain superfamily / Armadillo-type fold / Ubiquitin-like domain superfamily / Protein kinase-like domain superfamily / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha / Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.8 Å |
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データ登録者 | Parkinson, G.N. / Vines, D. / Driscoll, P.C. / Djordjevic, S. |
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引用 | ジャーナル: To be Published タイトル: Ligand-binding specificity of PI3Kinase C2alpha PX domain. 著者: Parkinson, G.N. / Vines, D. / Driscoll, P.C. / Djordjevic, S. |
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履歴 | 登録 | 2005年8月19日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2006年10月24日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月30日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Non-polymer description / Version format compliance |
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改定 1.3 | 2023年8月23日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ref_seq_dif / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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