- PDB-1ywt: Crystal structure of the human sigma isoform of 14-3-3 in complex... -
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基本情報
登録情報
データベース: PDB / ID: 1ywt
タイトル
Crystal structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide
要素
14-3-3 protein sigma
synthetic optimal phosphopeptide (mode-1)
キーワード
SIGNALING PROTEIN/DE NOVO PROTEIN / protein-phosphopeptide complex / 14-3-3 (14-3-3タンパク質) / SIGNALING PROTEIN-DE NOVO PROTEIN COMPLEX
機能・相同性
機能・相同性情報
regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / ケラチン / Regulation of localization of FOXO transcription factors / keratinocyte proliferation / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / negative regulation of keratinocyte proliferation ...regulation of epidermal cell division / protein kinase C inhibitor activity / positive regulation of epidermal cell differentiation / keratinocyte development / ケラチン / Regulation of localization of FOXO transcription factors / keratinocyte proliferation / phosphoserine residue binding / Activation of BAD and translocation to mitochondria / negative regulation of keratinocyte proliferation / establishment of skin barrier / SARS-CoV-2 targets host intracellular signalling and regulatory pathways / Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex / protein kinase A signaling / negative regulation of stem cell proliferation / SARS-CoV-1 targets host intracellular signalling and regulatory pathways / RHO GTPases activate PKNs / protein export from nucleus / negative regulation of innate immune response / protein sequestering activity / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / release of cytochrome c from mitochondria / positive regulation of protein export from nucleus / stem cell proliferation / Translocation of SLC2A4 (GLUT4) to the plasma membrane / TP53 Regulates Metabolic Genes / negative regulation of protein kinase activity / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / intrinsic apoptotic signaling pathway in response to DNA damage / positive regulation of cell growth / regulation of cell cycle / cadherin binding / protein kinase binding / negative regulation of transcription by RNA polymerase II / シグナル伝達 / extracellular space / extracellular exosome / identical protein binding / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能
SEQUENCE Chains C and D are an optimal phosphopeptide sequence as determined from a library screen, ...SEQUENCE Chains C and D are an optimal phosphopeptide sequence as determined from a library screen, and therefore have no database match.