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Yorodumi- PDB-1xwd: Crystal Structure of Human Follicle Stimulating Hormone Complexed... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1xwd | |||||||||
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Title | Crystal Structure of Human Follicle Stimulating Hormone Complexed with its Receptor | |||||||||
Components |
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Keywords | Hormone/Growth Factor / Hormone-receptor complex / Leucine-rich repeats / Cysteine-knot motif / Hormone-Growth Factor COMPLEX | |||||||||
Function / homology | Function and homology information follicle-stimulating hormone receptor activity / progesterone biosynthetic process / follicle-stimulating hormone activity / follicle-stimulating hormone complex / pituitary gonadotropin complex / luteinizing hormone secretion / follicle-stimulating hormone secretion / positive regulation of steroid biosynthetic process / Thyroxine biosynthesis / Mineralocorticoid biosynthesis ...follicle-stimulating hormone receptor activity / progesterone biosynthetic process / follicle-stimulating hormone activity / follicle-stimulating hormone complex / pituitary gonadotropin complex / luteinizing hormone secretion / follicle-stimulating hormone secretion / positive regulation of steroid biosynthetic process / Thyroxine biosynthesis / Mineralocorticoid biosynthesis / Hormone ligand-binding receptors / Glycoprotein hormones / Reactions specific to the complex N-glycan synthesis pathway / Androgen biosynthesis / follicle-stimulating hormone signaling pathway / female gamete generation / Sertoli cell proliferation / gonad development / negative regulation of organ growth / cellular response to follicle-stimulating hormone stimulus / regulation of osteoclast differentiation / regulation of protein kinase A signaling / thyroid hormone generation / G protein-coupled peptide receptor activity / regulation of signaling receptor activity / organ growth / female gonad development / thyroid gland development / positive regulation of bone resorption / TFAP2 (AP-2) family regulates transcription of growth factors and their receptors / hormone-mediated signaling pathway / transforming growth factor beta receptor signaling pathway / female pregnancy / adenylate cyclase-activating G protein-coupled receptor signaling pathway / hormone activity / Golgi lumen / male gonad development / G alpha (s) signalling events / spermatogenesis / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / positive regulation of ERK1 and ERK2 cascade / receptor complex / positive regulation of cell migration / G protein-coupled receptor signaling pathway / positive regulation of cell population proliferation / positive regulation of gene expression / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular region / membrane / plasma membrane / cytoplasm Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.92 Å | |||||||||
Authors | Fan, Q.R. / Hendrickson, W.A. | |||||||||
Citation | Journal: Nature / Year: 2005 Title: Structure of human follicle-stimulating hormone in complex with its receptor. Authors: Fan, Q.R. / Hendrickson, W.A. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1xwd.cif.gz | 188.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1xwd.ent.gz | 149.5 KB | Display | PDB format |
PDBx/mmJSON format | 1xwd.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/xw/1xwd ftp://data.pdbj.org/pub/pdb/validation_reports/xw/1xwd | HTTPS FTP |
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-Related structure data
Related structure data | 1fl7S S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
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