登録情報 | データベース: PDB / ID: 1xtg |
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タイトル | Crystal structure of NEUROTOXIN BONT/A complexed with Synaptosomal-associated protein 25 |
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要素 | - NEUROTOXIN BONT/A
- Synaptosomal-associated protein 25SNAP25
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キーワード | TOXIN (毒素) / botox (ボツリヌストキシン) / botulism (ボツリヌス症) / exosites |
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機能・相同性 | 機能・相同性情報
Toxicity of botulinum toxin type C (botC) / neurotransmitter uptake / Toxicity of botulinum toxin type E (botE) / exocytic insertion of neurotransmitter receptor to postsynaptic membrane / Acetylcholine Neurotransmitter Release Cycle / extrinsic component of presynaptic membrane / synaptic vesicle fusion to presynaptic active zone membrane / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex / synaptobrevin 2-SNAP-25-syntaxin-1a complex / Toxicity of botulinum toxin type A (botA) ...Toxicity of botulinum toxin type C (botC) / neurotransmitter uptake / Toxicity of botulinum toxin type E (botE) / exocytic insertion of neurotransmitter receptor to postsynaptic membrane / Acetylcholine Neurotransmitter Release Cycle / extrinsic component of presynaptic membrane / synaptic vesicle fusion to presynaptic active zone membrane / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex / synaptobrevin 2-SNAP-25-syntaxin-1a complex / Toxicity of botulinum toxin type A (botA) / synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex / Serotonin Neurotransmitter Release Cycle / GABA synthesis, release, reuptake and degradation / presynaptic dense core vesicle exocytosis / ribbon synapse / synaptic vesicle docking / Dopamine Neurotransmitter Release Cycle / Norepinephrine Neurotransmitter Release Cycle / SNARE complex / SNAP receptor activity / Glutamate Neurotransmitter Release Cycle / ボツリヌストキシン / host cell presynaptic membrane / neurotransmitter receptor internalization / host cell cytoplasmic vesicle / Sensory processing of sound by inner hair cells of the cochlea / syntaxin-1 binding / SNARE complex assembly / host cell cytosol / synaptic vesicle priming / regulation of neuron projection development / regulation of synapse assembly / endosomal transport / Other interleukin signaling / myosin binding / エキソサイトーシス / voltage-gated potassium channel activity / synaptic vesicle exocytosis / regulation of insulin secretion / 学習 / tertiary granule membrane / protein transmembrane transporter activity / long-term memory / specific granule membrane / axonal growth cone / presynaptic active zone membrane / voltage-gated potassium channel complex / photoreceptor inner segment / 軸索誘導 / locomotory behavior / filopodium / Regulation of insulin secretion / long-term synaptic potentiation / ゴルジ体 / positive regulation of insulin secretion / metalloendopeptidase activity / calcium-dependent protein binding / マイクロフィラメント / シナプス小胞 / lamellipodium / presynaptic membrane / 細胞皮質 / toxin activity / 成長円錐 / postsynapse / chemical synaptic transmission / transmembrane transporter binding / 細胞骨格 / エンドソーム / neuron projection / protein domain specific binding / neuronal cell body / glutamatergic synapse / lipid binding / Neutrophil degranulation / host cell plasma membrane / perinuclear region of cytoplasm / タンパク質分解 / zinc ion binding / extracellular region / 生体膜 / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 SNAP25 / SNAP-25 domain / SNAP-25 family / Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #110 / Zincin-like / Metalloproteases ("zincins"), catalytic domain like / Helical region found in SNAREs / t-SNARE coiled-coil homology domain profile. / Target SNARE coiled-coil homology domain / Clostridium neurotoxin, translocation ...SNAP25 / SNAP-25 domain / SNAP-25 family / Single alpha-helices involved in coiled-coils or other helix-helix interfaces - #110 / Zincin-like / Metalloproteases ("zincins"), catalytic domain like / Helical region found in SNAREs / t-SNARE coiled-coil homology domain profile. / Target SNARE coiled-coil homology domain / Clostridium neurotoxin, translocation / Clostridium neurotoxin, Translocation domain / Clostridium neurotoxin, translocation domain / Clostridial neurotoxin zinc protease / Botulinum/Tetanus toxin, catalytic chain / Clostridium neurotoxin, receptor binding N-terminal / Clostridium neurotoxin, receptor-binding C-terminal / Clostridium neurotoxin, C-terminal receptor binding / Clostridium neurotoxin, N-terminal receptor binding / Kunitz inhibitor STI-like superfamily / Single alpha-helices involved in coiled-coils or other helix-helix interfaces / Neutral zinc metallopeptidases, zinc-binding region signature. / Concanavalin A-like lectin/glucanase domain superfamily / Alpha-Beta Complex / Up-down Bundle / Mainly Alpha / Alpha Beta類似検索 - ドメイン・相同性 |
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生物種 | Clostridium botulinum (ボツリヌス菌) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 単波長異常分散, 分子置換 / 解像度: 2.1 Å |
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データ登録者 | Breidenbach, M.A. / Brunger, A.T. |
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引用 | ジャーナル: Nature / 年: 2004 タイトル: Substrate recognition strategy for botulinum neurotoxin serotype A 著者: Breidenbach, M.A. / Brunger, A.T. |
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履歴 | 登録 | 2004年10月21日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2004年12月21日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月30日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2018年1月31日 | Group: Advisory / Experimental preparation カテゴリ: exptl_crystal_grow / pdbx_unobs_or_zero_occ_atoms Item: _exptl_crystal_grow.pdbx_details / _exptl_crystal_grow.temp |
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改定 1.4 | 2021年10月20日 | Group: Advisory / Database references / Derived calculations カテゴリ: database_2 / pdbx_struct_conn_angle ...database_2 / pdbx_struct_conn_angle / pdbx_unobs_or_zero_occ_atoms / struct_conn / struct_ref_seq_dif / struct_sheet / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_sheet.number_strands / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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改定 1.5 | 2024年2月14日 | Group: Data collection / カテゴリ: chem_comp_atom / chem_comp_bond |
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