登録情報 データベース : PDB / ID : 1wm0 構造の表示 ダウンロードとリンクタイトル PPARgamma in complex with a 2-BABA compound 要素14-mer from Nuclear receptor coactivator 2 Peroxisome proliferator activated receptor gamma 詳細キーワード TRANSCRIPTION/SIGNALING PROTEIN / three-layer helical domain / TRANSCRIPTION-SIGNALING PROTEIN COMPLEX機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
: / : / : / negative regulation of pancreatic stellate cell proliferation / response to metformin / RNA polymerase II-specific DNA-binding transcription factor binding => GO:0061629 / : / DNA-binding transcription factor binding => GO:0140297 / cellular response to vitamin E / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 ... : / : / : / negative regulation of pancreatic stellate cell proliferation / response to metformin / RNA polymerase II-specific DNA-binding transcription factor binding => GO:0061629 / : / DNA-binding transcription factor binding => GO:0140297 / cellular response to vitamin E / Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 / cellular response to hyperoxia / Recycling of bile acids and salts / Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol / Synthesis of bile acids and bile salts via 27-hydroxycholesterol / Synthesis of bile acids and bile salts / positive regulation of glucocorticoid receptor signaling pathway / negative regulation of miRNA-mediated gene silencing / Endogenous sterols / HATs acetylate histones / : / negative regulation of collagen biosynthetic process / response to xenobiotic stimulus => GO:0009410 / positive regulation of fatty acid oxidation / Regulation of lipid metabolism by PPARalpha / chromatin => GO:0000785 / Cytoprotection by HMOX1 / nuclear glucocorticoid receptor binding / Estrogen-dependent gene expression / positive regulation of phagocytosis, engulfment / negative regulation of telomerase activity / nuclear retinoic acid receptor binding / response to vitamin A / prostaglandin receptor activity / regulation of cholesterol transporter activity / negative regulation of connective tissue replacement involved in inflammatory response wound healing / negative regulation of receptor signaling pathway via STAT / MECP2 regulates transcription factors / positive regulation of female receptivity / negative regulation of extracellular matrix assembly / negative regulation of vascular endothelial cell proliferation / negative regulation of cellular response to transforming growth factor beta stimulus / response to caffeine / negative regulation of cardiac muscle hypertrophy in response to stress / arachidonic acid binding / nuclear thyroid hormone receptor binding / positive regulation of low-density lipoprotein receptor activity / positive regulation of adiponectin secretion / lipoprotein transport / negative regulation of sequestering of triglyceride / macrophage derived foam cell differentiation / positive regulation of vascular associated smooth muscle cell apoptotic process / DNA binding domain binding / STAT family protein binding / RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding / positive regulation of oligodendrocyte differentiation / positive regulation of fatty acid metabolic process / response to lipid / negative regulation of SMAD protein signal transduction / response to starvation / LBD domain binding / negative regulation of type II interferon-mediated signaling pathway / negative regulation of cholesterol storage / E-box binding / alpha-actinin binding / lipid homeostasis / locomotor rhythm / Β酸化 / negative regulation of vascular associated smooth muscle cell proliferation / R-SMAD binding / monocyte differentiation / aryl hydrocarbon receptor binding / transcription factor binding / negative regulation of macrophage derived foam cell differentiation / cellular response to low-density lipoprotein particle stimulus / negative regulation of lipid storage / negative regulation of blood vessel endothelial cell migration / regulation of lipid metabolic process / negative regulation of acute inflammatory response / response to immobilization stress / negative regulation of BMP signaling pathway / cellular response to Thyroglobulin triiodothyronine / white fat cell differentiation / regulation of glucose metabolic process / negative regulation of mitochondrial fission / positive regulation of cholesterol efflux / retinoic acid receptor signaling pathway / positive regulation of fat cell differentiation / negative regulation of osteoblast differentiation / 細胞分化 / positive regulation of DNA binding / BMP signaling pathway / animal organ regeneration / long-chain fatty acid transport / nuclear retinoid X receptor binding / response to mechanical stimulus / DNA polymerase binding / negative regulation of signaling receptor activity / cellular response to retinoic acid / regulation of cellular response to insulin stimulus / cell maturation 類似検索 - 分子機能 PPARγ / Peroxisome proliferator-activated receptor gamma, N-terminal / PPAR gamma N-terminal region / 核内受容体コアクチベーター2 / Nuclear receptor coactivator 2/3, DUF4927 / Domain of unknown function (DUF4927) / PPAR / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator, Ncoa-type, interlocking / Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily ... PPARγ / Peroxisome proliferator-activated receptor gamma, N-terminal / PPAR gamma N-terminal region / 核内受容体コアクチベーター2 / Nuclear receptor coactivator 2/3, DUF4927 / Domain of unknown function (DUF4927) / PPAR / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator, Ncoa-type, interlocking / Nuclear receptor coactivator, Ncoa-type, interlocking domain superfamily / Nuclear receptor coactivator, DUF1518 / Nuclear receptor coactivator / DUF1518 / Nuclear receptor coactivator, receptor-binding domain / Nuclear receptor coactivator / Steroid receptor coactivator / Unstructured region on nuclear receptor coactivator protein / PAS domain / Helix-loop-helix DNA-binding domain superfamily / helix loop helix domain / Myc-type, basic helix-loop-helix (bHLH) domain / Myc-type, basic helix-loop-helix (bHLH) domain profile. / Nuclear receptor coactivator, interlocking / PAS fold / PAS fold / PAS domain / PAS repeat profile. / PAS domain / PAS domain superfamily / Retinoid X Receptor / Retinoid X Receptor / 核内受容体 / Nuclear hormones receptors DNA-binding region signature. / Zinc finger, nuclear hormone receptor-type / Zinc finger, C4 type (two domains) / Nuclear hormone receptors DNA-binding domain profile. / c4 zinc finger in nuclear hormone receptors / Nuclear hormone receptor, ligand-binding domain / Nuclear hormone receptor-like domain superfamily / Ligand-binding domain of nuclear hormone receptor / Nuclear receptor (NR) ligand-binding (LBD) domain profile. / Ligand binding domain of hormone receptors / Zinc finger, NHR/GATA-type / Orthogonal Bundle / Mainly Alpha 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / 分子置換 / 解像度 : 2.9 Å 詳細データ登録者 Ostberg, T. / Svensson, S. / Selen, G. / Uppenberg, J. / Thor, M. / Sundbom, M. / Sydow-Backman, M. / Gustavsson, A.L. / Jendeberg, L. 引用ジャーナル : J.Biol.Chem. / 年 : 2004タイトル : A new class of peroxisome proliferator-activated receptor agonists with a novel binding epitope shows antidiabetic effects著者 : Ostberg, T. / Svensson, S. / Selen, G. / Uppenberg, J. / Thor, M. / Sundbom, M. / Sydow-Backman, M. / Gustavsson, A.L. / Jendeberg, L. 履歴 登録 2004年7月1日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2004年9月7日 Provider : repository / タイプ : Initial release改定 1.1 2008年4月30日 Group : Version format compliance改定 1.2 2011年7月13日 Group : Version format compliance改定 1.3 2024年3月13日 Group : Data collection / Database references / Derived calculationsカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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