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- PDB-1twr: Crystal structures of ferrous and ferrous-NO forms of verdoheme i... -
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Basic information
Entry | Database: PDB / ID: 1twr | ||||||
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Title | Crystal structures of ferrous and ferrous-NO forms of verdoheme in a complex with human heme oxygenase-1: catalytic implications for heme cleavage | ||||||
![]() | Heme oxygenase 1![]() | ||||||
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Function / homology | ![]() Regulation of HMOX1 expression and activity / heme oxygenase (biliverdin-producing) / low-density lipoprotein particle clearance / cellular response to cisplatin / heme oxidation / smooth muscle hyperplasia / negative regulation of leukocyte migration / ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() ![]() Similarity search - Function | ||||||
Biological species | ![]() ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Lad, L. / Ortiz de Montellano, P.R. / Poulos, T.L. | ||||||
![]() | ![]() Title: Crystal structures of ferrous and ferrous-NO forms of verdoheme in a complex with human heme oxygenase-1: catalytic implications for heme cleavage. Authors: Lad, L. / Ortiz de Montellano, P.R. / Poulos, T.L. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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Downloads & links
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PDBx/mmCIF format | ![]() | 104.3 KB | Display | ![]() |
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PDB format | ![]() | 79.8 KB | Display | ![]() |
PDBx/mmJSON format | ![]() | Tree view | ![]() | |
Others | ![]() |
-Validation report
Arichive directory | ![]() ![]() | HTTPS FTP |
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-Related structure data
Related structure data | ![]() 1twnC ![]() 1qq8 C: citing same article ( S: Starting model for refinement |
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Similar structure data |
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Links
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Assembly
Deposited unit | ![]()
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Unit cell |
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Components
#1: Protein | ![]() Mass: 26898.615 Da / Num. of mol.: 2 Source method: isolated from a genetically manipulated source Source: (gene. exp.) ![]() ![]() ![]() ![]() ![]() References: UniProt: P09601, heme oxygenase (biliverdin-producing) #2: Chemical | #3: Chemical | ![]() #4: Water | ChemComp-HOH / | ![]() |
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-Experimental details
-Experiment
Experiment | Method: ![]() |
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Sample preparation
Crystal | Density Matthews: 2 Å3/Da / Density % sol: 23 % |
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Crystal grow![]() | Temperature: 301 K / Method: liquid diffusion / pH: 8 Details: NH4SO4, Hepes, NaCl, pH 8.0, LIQUID DIFFUSION, temperature 301K |
-Data collection
Diffraction | Mean temperature: 119 K |
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Diffraction source | Source: ![]() ![]() ![]() |
Detector | Type: ADSC QUANTUM 4 / Detector: CCD |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Relative weight: 1 |
Reflection | Resolution: 2.1→50 Å / Num. all: 64321 / Num. obs: 59654 / % possible obs: 93.1 % / Observed criterion σ(F): 2 / Observed criterion σ(I): 2 / Redundancy: 8.1 % / Rmerge(I) obs: 0.097 / Rsym value: 0.025 / Net I/σ(I): 10.3 |
Reflection shell | Resolution: 2.1→2.18 Å / Redundancy: 5.1 % / Rmerge(I) obs: 0.082 / Mean I/σ(I) obs: 2 / Num. unique all: 5476 / Rsym value: 0.25 / % possible all: 94.3 |
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Processing
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Refinement | Method to determine structure![]() ![]() Starting model: pdb entry 1qq8 ![]() 1qq8 Highest resolution: 2.1 Å / Isotropic thermal model: isotropic / Cross valid method: THROUGHOUT / σ(I): 2 / Stereochemistry target values: Engh & Huber
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Refinement step | Cycle: LAST / Highest resolution: 2.1 Å
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Refine LS restraints |
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LS refinement shell | Resolution: 2.1→2.18 Å
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