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- PDB-1ron: NMR SOLUTION STRUCTURE OF HUMAN NEUROPEPTIDE Y -

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Basic information

Entry
Database: PDB / ID: 1ron
TitleNMR SOLUTION STRUCTURE OF HUMAN NEUROPEPTIDE Y
ComponentsNEUROPEPTIDE Y
KeywordsNEUROPEPTIDE / CLEAVAGE ON PAIR OF BASIC RESIDUES / AMIDATION / NEUROMODULATOR
Function / homology
Function and homology information


synaptic signaling via neuropeptide / neuropeptide Y receptor binding / intestinal epithelial cell differentiation / positive regulation of appetite / adult feeding behavior / neuropeptide hormone activity / feeding behavior / central nervous system neuron development / neuronal dense core vesicle / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger ...synaptic signaling via neuropeptide / neuropeptide Y receptor binding / intestinal epithelial cell differentiation / positive regulation of appetite / adult feeding behavior / neuropeptide hormone activity / feeding behavior / central nervous system neuron development / neuronal dense core vesicle / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / calcium channel regulator activity / neuropeptide signaling pathway / GABA-ergic synapse / FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes / Peptide ligand-binding receptors / G protein-coupled receptor activity / cerebral cortex development / regulation of blood pressure / neuron projection development / G alpha (i) signalling events / chemical synaptic transmission / signaling receptor binding / Golgi apparatus / extracellular space / extracellular region
Similarity search - Function
Pancreatic hormone-like / Pancreatic hormone-like, conserved site / Pancreatic hormone peptide / Pancreatic hormone family signature. / Pancreatic hormone family profile. / Pancreatic hormones / neuropeptide F / peptide YY family
Similarity search - Domain/homology
Biological speciesHomo sapiens (human)
MethodSOLUTION NMR
AuthorsMonks, S.A. / Karagianis, G. / Howlett, G.J. / Norton, R.S.
Citation
Journal: J.Biomol.NMR / Year: 1996
Title: Solution structure of human neuropeptide Y.
Authors: Monks, S.A. / Karagianis, G. / Howlett, G.J. / Norton, R.S.
#1: Journal: To be Published
Title: Solution Structure of Shk Toxin, a Novel Potassium Channel Inhibitor from a Sea Anemone
Authors: Grimes, J.E. / Pallaghy, P.K. / Pennington, M.W. / Norton, R.S.
History
DepositionJan 11, 1996Processing site: BNL
Revision 1.0Aug 17, 1996Provider: repository / Type: Initial release
Revision 1.1Mar 24, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3May 25, 2016Group: Source and taxonomy
Revision 1.4Nov 29, 2017Group: Derived calculations / Other
Category: pdbx_database_status / struct_conf / struct_conf_type
Item: _pdbx_database_status.process_site

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: NEUROPEPTIDE Y


Theoretical massNumber of molelcules
Total (without water)4,2771
Polymers4,2771
Non-polymers00
Water0
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)26 / 26
Representative

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Components

#1: Protein/peptide NEUROPEPTIDE Y / / NPY


Mass: 4276.728 Da / Num. of mol.: 1 / Source method: obtained synthetically / Details: SYNTHESIZED BY AUSPEP PTY. LTD., AUSTRALIA / Source: (synth.) Homo sapiens (human) / References: UniProt: P01303

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Sample conditionspH: 3.2 / Temperature: 310 K
Crystal grow
*PLUS
Method: other / Details: NMR

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Processing

Software
NameVersionClassification
X-PLOR3.1model building
X-PLOR3.1refinement
X-PLOR3.1phasing
NMR software
NameVersionDeveloperClassification
X-PLOR3.1BRUNGERrefinement
XPLOR3.1structure solution
NMR ensembleConformers calculated total number: 26 / Conformers submitted total number: 26

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