登録情報 | データベース: PDB / ID: 1pvh |
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タイトル | Crystal structure of leukemia inhibitory factor in complex with gp130 |
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要素 | - Interleukin-6 receptor beta chain
- Leukemia inhibitory factor
白血病阻止因子 |
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キーワード | signaling protein/cytokine / cytokine (サイトカイン) / receptor (受容体) / signaling / beta sheet (Βシート) / four helix bundle / signaling protein-cytokine COMPLEX |
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機能・相同性 | 機能・相同性情報
leukemia inhibitory factor receptor binding / spongiotrophoblast differentiation / meiotic nuclear division / positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis / negative regulation of meiotic nuclear division / muscle organ morphogenesis / interleukin-27 receptor activity / cell surface receptor signaling pathway via STAT / oncostatin-M receptor complex / oncostatin-M-mediated signaling pathway ... leukemia inhibitory factor receptor binding / spongiotrophoblast differentiation / meiotic nuclear division / positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis / negative regulation of meiotic nuclear division / muscle organ morphogenesis / interleukin-27 receptor activity / cell surface receptor signaling pathway via STAT / oncostatin-M receptor complex / oncostatin-M-mediated signaling pathway / ciliary neurotrophic factor receptor activity / ciliary neurotrophic factor receptor binding / negative regulation of interleukin-6-mediated signaling pathway / leukemia inhibitory factor signaling pathway / interleukin-11 receptor activity / interleukin-11 binding / interleukin-6 receptor activity / interleukin-6 binding / ciliary neurotrophic factor receptor complex / interleukin-27-mediated signaling pathway / ciliary neurotrophic factor-mediated signaling pathway / interleukin-6 receptor complex / regulation of metanephric nephron tubule epithelial cell differentiation / positive regulation of peptidyl-serine phosphorylation of STAT protein / negative regulation of hormone secretion / trophoblast giant cell differentiation / lung vasculature development / interleukin-11-mediated signaling pathway / lung lobe morphogenesis / T-helper 17 cell lineage commitment / positive regulation of adaptive immune response / positive regulation of macrophage differentiation / positive regulation of acute inflammatory response / positive regulation of astrocyte differentiation / intestinal epithelial cell development / positive regulation of platelet aggregation / Interleukin-35 Signalling / Interleukin-27 signaling / IL-6-type cytokine receptor ligand interactions / positive regulation of cell adhesion mediated by integrin / cytokine receptor activity / glycogen metabolic process / interleukin-6-mediated signaling pathway / Interleukin-6 signaling / lung alveolus development / positive regulation of Notch signaling pathway / protein tyrosine kinase activator activity / positive regulation of cardiac muscle hypertrophy / cytokine binding / regulation of cell differentiation / MAPK3 (ERK1) activation / growth factor binding / Interleukin-10 signaling / somatic stem cell population maintenance / MAPK1 (ERK2) activation / macrophage differentiation / decidualization / positive regulation of vascular endothelial growth factor production / neuron development / blood vessel remodeling / positive regulation of osteoblast differentiation / coreceptor activity / positive regulation of T cell proliferation / positive regulation of tyrosine phosphorylation of STAT protein / 着床 / response to cytokine / cytokine activity / 細胞分化 / growth factor activity / cell morphogenesis / negative regulation of ERK1 and ERK2 cascade / cytokine-mediated signaling pathway / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of fibroblast proliferation / positive regulation of peptidyl-serine phosphorylation / 遺伝子発現 / fibroblast proliferation / scaffold protein binding / Interleukin-4 and Interleukin-13 signaling / negative regulation of neuron apoptotic process / positive regulation of MAPK cascade / receptor complex / response to hypoxia / 免疫応答 / 脂質ラフト / negative regulation of cell population proliferation / external side of plasma membrane / signaling receptor binding / neuronal cell body / 樹状突起 / positive regulation of cell population proliferation / positive regulation of gene expression / negative regulation of apoptotic process / positive regulation of transcription by RNA polymerase II / extracellular space / extracellular exosome / extracellular region / 生体膜 / identical protein binding / 細胞膜類似検索 - 分子機能 白血病阻止因子 / Leukemia inhibitory factor /oncostatin / Leukemia inhibitory factor /oncostatin, conserved site / LIF / OSM family / LIF / OSM family signature. / 白血病阻止因子 / Type I cytokine receptor, cytokine-binding domain / Interleukin-6 receptor alpha chain, binding / Immunoglobulin C2-set-like, ligand-binding / 免疫グロブリンスーパーファミリー ... 白血病阻止因子 / Leukemia inhibitory factor /oncostatin / Leukemia inhibitory factor /oncostatin, conserved site / LIF / OSM family / LIF / OSM family signature. / 白血病阻止因子 / Type I cytokine receptor, cytokine-binding domain / Interleukin-6 receptor alpha chain, binding / Immunoglobulin C2-set-like, ligand-binding / 免疫グロブリンスーパーファミリー / Long hematopoietin receptor, Gp130 family 2, conserved site / Long hematopoietin receptor, gp130 family signature. / Growth Hormone; Chain: A; - #10 / Four-helical cytokine-like, core / Growth Hormone; Chain: A; / フィブロネクチンIII型ドメイン / Fibronectin type 3 domain / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / 抗体 / Immunoglobulin-like fold / Up-down Bundle / Immunoglobulin-like / サンドイッチ / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性IODIDE ION / 白血病阻止因子 / Interleukin-6 receptor subunit beta類似検索 - 構成要素 |
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生物種 | ![](img/tx_human.gif) Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.5 Å |
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データ登録者 | Boulanger, M.J. / Bankovich, A.J. / Kortemme, T. / Baker, D. / Garcia, K.C. |
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引用 | ジャーナル: Mol.Cell / 年: 2003 タイトル: Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. 著者: Boulanger, M.J. / Bankovich, A.J. / Kortemme, T. / Baker, D. / Garcia, K.C. |
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履歴 | 登録 | 2003年6月27日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2003年10月14日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2008年4月29日 | Group: Version format compliance |
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改定 1.2 | 2011年7月13日 | Group: Version format compliance |
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改定 1.3 | 2023年8月16日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_site Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id |
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