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- PDB-1l4t: SOLUTION NMR STRUCTURE OF THE CCK2E3 -

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Basic information

Entry
Database: PDB / ID: 1l4t
TitleSOLUTION NMR STRUCTURE OF THE CCK2E3
ComponentsGastrin/cholecystokinin type B receptor
KeywordsHORMONE/GROWTH FACTOR RECEPTOR / HORMONE-GROWTH FACTOR RECEPTOR complex
Function / homology
Function and homology information


gastrin receptor activity / type B gastrin/cholecystokinin receptor binding / gland development / gastric acid secretion / pH reduction / cholecystokinin receptor activity / cholecystokinin signaling pathway / 1-phosphatidylinositol-3-kinase regulator activity / Gastrin-CREB signalling pathway via PKC and MAPK / digestive tract development ...gastrin receptor activity / type B gastrin/cholecystokinin receptor binding / gland development / gastric acid secretion / pH reduction / cholecystokinin receptor activity / cholecystokinin signaling pathway / 1-phosphatidylinositol-3-kinase regulator activity / Gastrin-CREB signalling pathway via PKC and MAPK / digestive tract development / peptide hormone binding / Peptide ligand-binding receptors / phospholipase C-activating G protein-coupled receptor signaling pathway / positive regulation of cytosolic calcium ion concentration / G alpha (q) signalling events / cell surface receptor signaling pathway / intracellular membrane-bounded organelle / positive regulation of cell population proliferation / plasma membrane
Similarity search - Function
Gastrin receptor / Cholecystokinin receptor / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family)
Similarity search - Domain/homology
Gastrin/cholecystokinin type B receptor
Similarity search - Component
MethodSOLUTION NMR
Model type detailsminimized average
AuthorsGiragossian, C. / Mierke, D.F.
CitationJournal: Biochemistry / Year: 2002
Title: Intermolecular interactions between cholecystokinin-8 and the third extracellular loop of the cholecystokinin-2 receptor
Authors: Giragossian, C. / Mierke, D.F.
History
DepositionMar 5, 2002Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jan 28, 2003Provider: repository / Type: Initial release
Revision 1.1Apr 28, 2008Group: Version format compliance
Revision 1.2Jul 13, 2011Group: Version format compliance
Revision 1.3Feb 23, 2022Group: Database references / Derived calculations
Category: database_2 / pdbx_struct_assembly ...database_2 / pdbx_struct_assembly / pdbx_struct_oper_list / struct_conn / struct_site
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_leaving_atom_flag / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id

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Structure visualization

Structure viewerMolecule:
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Assembly

Deposited unit
A: Gastrin/cholecystokinin type B receptor


Theoretical massNumber of molelcules
Total (without water)2,9911
Polymers2,9911
Non-polymers00
Water0
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)1 / -
Representativeminimized average structure

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Components

#1: Protein/peptide Gastrin/cholecystokinin type B receptor / CCK2E3, CCK-B receptor, CCK-BR


Mass: 2991.391 Da / Num. of mol.: 1 / Fragment: EXTRACELLULAR DOMAIN, Residues 352-379 / Source method: obtained synthetically
Details: The peptide was synthesized using solid phase peptide synthesis. The sequence occurs naturally in Homo sapiens (Humans).
References: UniProt: P32239

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR

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Sample preparation

Crystal grow
*PLUS
Method: other / Details: NMR

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NMR measurement

RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M
Radiation wavelengthRelative weight: 1

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Processing

NMR representativeSelection criteria: minimized average structure
NMR ensembleConformers submitted total number: 1

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