Entry Database : PDB / ID : 1h59 Structure visualization Downloads & linksTitle Complex of IGFBP-5 with IGF-I ComponentsINSULIN-LIKE GROWTH FACTOR BINDING PROTEIN 5 INSULIN-LIKE GROWTH FACTOR IA DetailsKeywords INSULIN / INSULIN-LIKE GROWTH FACTOR / IGF BINDING PROTEINFunction / homology Function and homology informationFunction Domain/homology Component
negative regulation of muscle tissue development / negative regulation of skeletal muscle hypertrophy / regulation of insulin-like growth factor receptor signaling pathway / glycolate metabolic process / muscle hypertrophy / negative regulation of oocyte development / positive regulation of trophectodermal cell proliferation / insulin-like growth factor binding protein complex / insulin-like growth factor ternary complex / negative regulation of insulin-like growth factor receptor signaling pathway ... negative regulation of muscle tissue development / negative regulation of skeletal muscle hypertrophy / regulation of insulin-like growth factor receptor signaling pathway / glycolate metabolic process / muscle hypertrophy / negative regulation of oocyte development / positive regulation of trophectodermal cell proliferation / insulin-like growth factor binding protein complex / insulin-like growth factor ternary complex / negative regulation of insulin-like growth factor receptor signaling pathway / proteoglycan biosynthetic process / negative regulation of smooth muscle cell migration / positive regulation of glycoprotein biosynthetic process / myotube cell development / skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration / negative regulation of neuroinflammatory response / mammary gland involution / negative regulation of vascular associated smooth muscle cell apoptotic process / bone mineralization involved in bone maturation / Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) / positive regulation of cell growth involved in cardiac muscle cell development / IRS-related events triggered by IGF1R / negative regulation of growth / exocytic vesicle / cell activation / positive regulation of calcineurin-NFAT signaling cascade / insulin-like growth factor II binding / type B pancreatic cell proliferation / positive regulation of transcription regulatory region DNA binding / insulin-like growth factor I binding / alphav-beta3 integrin-IGF-1-IGF1R complex / positive regulation of vascular associated smooth muscle cell migration / positive regulation of Ras protein signal transduction / response to growth hormone / myoblast differentiation / positive regulation of insulin-like growth factor receptor signaling pathway / myoblast proliferation / muscle organ development / negative regulation of interleukin-1 beta production / hair follicle morphogenesis / lung alveolus development / positive regulation of cardiac muscle hypertrophy / positive regulation of activated T cell proliferation / positive regulation of smooth muscle cell migration / negative regulation of release of cytochrome c from mitochondria / negative regulation of amyloid-beta formation / negative regulation of smooth muscle cell apoptotic process / fibronectin binding / cellular response to organic cyclic compound / negative regulation of tumor necrosis factor production / positive regulation of glycogen biosynthetic process / Synthesis, secretion, and deacylation of Ghrelin / epithelial to mesenchymal transition / negative regulation of osteoblast differentiation / positive regulation of DNA binding / SHC-related events triggered by IGF1R / positive regulation of osteoblast differentiation / cellular response to cAMP / positive regulation of tyrosine phosphorylation of STAT protein / positive regulation of vascular associated smooth muscle cell proliferation / striated muscle cell differentiation / insulin-like growth factor receptor binding / positive regulation of glycolytic process / activation of protein kinase B activity / positive regulation of mitotic nuclear division / negative regulation of cell migration / insulin-like growth factor receptor signaling pathway / platelet alpha granule lumen / skeletal system development / female pregnancy / positive regulation of epithelial cell proliferation / positive regulation of protein secretion / regulation of cell growth / positive regulation of glucose import / negative regulation of extrinsic apoptotic signaling pathway / negative regulation of smooth muscle cell proliferation / Post-translational protein phosphorylation / positive regulation of smooth muscle cell proliferation / regulation of protein phosphorylation / growth factor activity / wound healing / insulin receptor binding / hormone activity / osteoblast differentiation / cellular response to amyloid-beta / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / positive regulation of peptidyl-tyrosine phosphorylation / positive regulation of fibroblast proliferation / integrin binding / Platelet degranulation / glucose homeostasis / response to heat / regulation of gene expression / cell population proliferation / Ras protein signal transduction / positive regulation of MAPK cascade / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of translation / positive regulation of ERK1 and ERK2 cascade / protein stabilization Similarity search - Function Insulin-like growth factor binding protein 5 / Omega-AgatoxinV - #20 / Insulin-like growth factor-binding protein family 1-6, chordata / Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site / Insulin-like growth factor-binding protein (IGFBP) N-terminal domain signature. / Omega-AgatoxinV / Insulin-like growth factor I / Insulin-like growth factor binding protein / Insulin-like, subunit E / Insulin-like ... Insulin-like growth factor binding protein 5 / Omega-AgatoxinV - #20 / Insulin-like growth factor-binding protein family 1-6, chordata / Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site / Insulin-like growth factor-binding protein (IGFBP) N-terminal domain signature. / Omega-AgatoxinV / Insulin-like growth factor I / Insulin-like growth factor binding protein / Insulin-like, subunit E / Insulin-like / Insulin-like growth factor-binding protein, IGFBP / Insulin-like growth factor-binding protein (IGFBP) N-terminal domain profile. / Insulin growth factor-binding protein homologues / Insulin-like growth factor / Thyroglobulin type-1 repeat signature. / Thyroglobulin type-1 / Thyroglobulin type-1 superfamily / Thyroglobulin type-1 repeat / Thyroglobulin type-1 domain profile. / Thyroglobulin type I repeats. / Insulin family / Insulin/IGF/Relaxin family / Insulin, conserved site / Insulin family signature. / Insulin-like / Insulin / insulin-like growth factor / relaxin family. / Insulin-like superfamily / Growth factor receptor cysteine-rich domain superfamily / Few Secondary Structures / Irregular / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SIR / Resolution : 2.1 Å DetailsAuthors Zeslawski, W. / Beisel, H.G. / Kamionka, M. / Kalus, W. / Engh, R.A. / Huber, R. / Holak, T.A. CitationJournal : Embo J. / Year : 2001Title : The Interaction of Insulin-Like Growth Factor-I with the N-Terminal Domain of Igfbp-5Authors : Zesaawski, W. / Beisel, H.G. / Kamionka, M. / Kalus, W. / Engh, R.A. / Huber, R. / Lang, K. / Holak, T.A. History Deposition May 21, 2001 Deposition site : PDBE / Processing site : PDBERevision 1.0 May 16, 2002 Provider : repository / Type : Initial releaseRevision 1.1 May 8, 2011 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format compliance
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