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Yorodumi- PDB-1gya: N-GLYCAN AND POLYPEPTIDE NMR SOLUTION STRUCTURES OF THE ADHESION ... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1gya | |||||||||
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Title | N-GLYCAN AND POLYPEPTIDE NMR SOLUTION STRUCTURES OF THE ADHESION DOMAIN OF HUMAN CD2 | |||||||||
Components | HUMAN CD2 | |||||||||
Keywords | ADHESION GLYCOPROTEIN / CELL SURFACE ADHESION RECEPTOR / IMMUNOGLOBULIN SUPERFAMILY V-SET DOMAIN / T LYMPHOCYTE ADHESION GLYCOPROTEIN | |||||||||
Function / homology | Function and homology information positive regulation of myeloid dendritic cell activation / membrane raft polarization / natural killer cell mediated cytotoxicity / natural killer cell activation / heterotypic cell-cell adhesion / regulation of T cell differentiation / T cell activation / positive regulation of interleukin-8 production / Cell surface interactions at the vascular wall / cytoplasmic side of plasma membrane ...positive regulation of myeloid dendritic cell activation / membrane raft polarization / natural killer cell mediated cytotoxicity / natural killer cell activation / heterotypic cell-cell adhesion / regulation of T cell differentiation / T cell activation / positive regulation of interleukin-8 production / Cell surface interactions at the vascular wall / cytoplasmic side of plasma membrane / receptor tyrosine kinase binding / cell-cell adhesion / : / positive regulation of tumor necrosis factor production / positive regulation of type II interferon production / cell-cell junction / signaling receptor activity / cell surface receptor signaling pathway / external side of plasma membrane / signaling receptor binding / apoptotic process / Golgi apparatus / cell surface / protein-containing complex / extracellular region / nucleoplasm / identical protein binding / plasma membrane Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | SOLUTION NMR / distance geometry | |||||||||
Authors | Wyss, D.F. / Choi, J.S. / Wagner, G. | |||||||||
Citation | Journal: Science / Year: 1995 Title: Conformation and function of the N-linked glycan in the adhesion domain of human CD2. Authors: Wyss, D.F. / Choi, J.S. / Li, J. / Knoppers, M.H. / Willis, K.J. / Arulanandam, A.R. / Smolyar, A. / Reinherz, E.L. / Wagner, G. #1: Journal: Biochemistry / Year: 1995 Title: Composition and Sequence Specific Resonance Assignments of the Heterogeneous N-Linked Glycan in the 13.6 KDa Adhesion Domain of Human Cd2 as Determined by NMR on the Intact Glycoprotein Authors: Wyss, D.F. / Choi, J.S. / Wagner, G. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1gya.cif.gz | 693.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1gya.ent.gz | 580.2 KB | Display | PDB format |
PDBx/mmJSON format | 1gya.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/gy/1gya ftp://data.pdbj.org/pub/pdb/validation_reports/gy/1gya | HTTPS FTP |
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-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 12453.215 Da / Num. of mol.: 1 / Fragment: ADHESION DOMAIN Source method: isolated from a genetically manipulated source Details: GLYCOSYLATED / Source: (gene. exp.) Homo sapiens (human) Description: THE ADHESION DOMAIN OF HUMAN CD2 (HSCD2=105=) WAS OBTAINED BY CLOSTRIPAIN DIGESTION OF THE TWO-DOMAIN HUMAN CD2 (HSCD2=182=) Gene: SCD2=182= / Organ: OVARY / Plasmid: PM1 / Gene (production host): SCD2=182= / Production host: Cricetulus griseus (Chinese hamster) / References: UniProt: P06729 |
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#2: Polysaccharide | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D- ...alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Source method: isolated from a genetically manipulated source |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Sample conditions | pH: 4.5 / Temperature: 286 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
-Processing
NMR software |
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Refinement | Method: distance geometry / Software ordinal: 1 | |||||||||
NMR ensemble | Conformer selection criteria: PROSTAT/STRUCT_CHECK / Conformers calculated total number: 120 / Conformers submitted total number: 18 |