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Yorodumi- PDB-1boe: STRUCTURE OF THE IGF BINDING DOMAIN OF THE INSULIN-LIKE GROWTH FA... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1boe | ||||||
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Title | STRUCTURE OF THE IGF BINDING DOMAIN OF THE INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-5 (IGFBP-5): IMPLICATIONS FOR IGF AND IGF-I RECEPTOR INTERACTIONS | ||||||
Components | PROTEIN (INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-5 (IGFBP-5)) | ||||||
Keywords | HORMONE/GROWTH FACTOR / MINI-IGFBP-5 / IGFBP-5 / IGF / INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN / HORMONE-GROWTH FACTOR COMPLEX | ||||||
Function / homology | Function and homology information negative regulation of muscle tissue development / negative regulation of skeletal muscle hypertrophy / regulation of insulin-like growth factor receptor signaling pathway / insulin-like growth factor binding protein complex / insulin-like growth factor ternary complex / negative regulation of insulin-like growth factor receptor signaling pathway / negative regulation of smooth muscle cell migration / mammary gland involution / negative regulation of growth / insulin-like growth factor II binding ...negative regulation of muscle tissue development / negative regulation of skeletal muscle hypertrophy / regulation of insulin-like growth factor receptor signaling pathway / insulin-like growth factor binding protein complex / insulin-like growth factor ternary complex / negative regulation of insulin-like growth factor receptor signaling pathway / negative regulation of smooth muscle cell migration / mammary gland involution / negative regulation of growth / insulin-like growth factor II binding / type B pancreatic cell proliferation / insulin-like growth factor I binding / positive regulation of vascular associated smooth muscle cell migration / response to growth hormone / positive regulation of insulin-like growth factor receptor signaling pathway / hair follicle morphogenesis / lung alveolus development / fibronectin binding / cellular response to organic cyclic compound / negative regulation of osteoblast differentiation / cellular response to cAMP / positive regulation of vascular associated smooth muscle cell proliferation / striated muscle cell differentiation / negative regulation of cell migration / insulin-like growth factor receptor signaling pathway / female pregnancy / regulation of cell growth / negative regulation of smooth muscle cell proliferation / Post-translational protein phosphorylation / osteoblast differentiation / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / glucose homeostasis / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of translation / intracellular signal transduction / endoplasmic reticulum lumen / signal transduction / extracellular space / extracellular region Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR / SIMUALTED ANNEALING | ||||||
Authors | Kalus, W. / Zweckstetter, M. / Renner, C. / Sanchez, Y. / Georgescu, J. / Grol, M. / Demuth, D. / Schumacherdony, C. / Lang, K. / Holak, T.H. | ||||||
Citation | Journal: EMBO J. / Year: 1998 Title: Structure of the IGF-binding domain of the insulin-like growth factor-binding protein-5 (IGFBP-5): implications for IGF and IGF-I receptor interactions. Authors: Kalus, W. / Zweckstetter, M. / Renner, C. / Sanchez, Y. / Georgescu, J. / Grol, M. / Demuth, D. / Schumacher, R. / Dony, C. / Lang, K. / Holak, T.A. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1boe.cif.gz | 271.4 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1boe.ent.gz | 232.5 KB | Display | PDB format |
PDBx/mmJSON format | 1boe.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/bo/1boe ftp://data.pdbj.org/pub/pdb/validation_reports/bo/1boe | HTTPS FTP |
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-Related structure data
Similar structure data | Similarity search - Function & homologyF&H Search |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein/peptide | Mass: 5208.933 Da / Num. of mol.: 1 / Fragment: BINDING DOMAIN / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P24593 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||
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NMR experiment |
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-Sample preparation
Sample conditions | pH: 4.5 / Pressure: 1 atm / Temperature: 303 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
-NMR measurement
NMR spectrometer | Type: Bruker DMX750 / Manufacturer: Bruker / Model: DMX750 / Field strength: 750 MHz |
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-Processing
NMR software |
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Refinement | Method: SIMUALTED ANNEALING / Software ordinal: 1 Details: REFINEMENT DETAILS CAN BE FOUND IN THE JRNL CITATION ABOVE | ||||||||||||
NMR ensemble | Conformer selection criteria: LEAST RESTRAINT VIOLATION / Conformers calculated total number: 60 / Conformers submitted total number: 20 |