EMDB-11796: The Large subunit of the Kinetoplastid mitochondrial ribosome

Basic information

• Entry: Database: EMDB / ID: EMD-11796
• Title: The Large subunit of the Kinetoplastid mitochondrial ribosome

Sample

• Complex: Leishmania mitochondrial ribosome
  • Protein or peptide: x 70 types
  • RNA: x 1 types
• Ligand: x 2 types

Function / homology

Function:

kinetoplast / nuclear lumen / mitochondrial large ribosomal subunit / ciliary plasm / mitochondrial ribosome / cyclosporin A binding / mitochondrial translation / peptidylprolyl isomerase / peptidyl-prolyl cis-trans isomerase activity / large ribosomal subunit rRNA binding / large ribosomal subunit / protein folding / negative regulation of translation / rRNA binding / ribosome / structural constituent of ribosome / ribonucleoprotein complex / translation / mRNA binding / mitochondrion / RNA binding / membrane / metal ion binding / nucleus / cytoplasm

Domain/homology:

PPR repeat family / Pentatricopeptide (PPR) repeat profile. / LIM domain / Pentatricopeptide repeat / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / Ribosomal protein L46, N-terminal / 39S mitochondrial ribosomal protein L46 / LIM domain profile. / 39S ribosomal protein L46, mitochondrial / Ribosomal protein L47, mitochondrial / MRP-L47 superfamily, mitochondrial / 39S ribosomal protein L43/54S ribosomal protein L51 / Mitochondrial 39-S ribosomal protein L47 (MRP-L47) / Phosphatidylethanolamine-binding protein, eukaryotic / PEBP-like superfamily / Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site / Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain profile. / Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain / Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD / Cyclophilin-like domain superfamily / AMP-dependent synthetase/ligase / AMP-binding enzyme / Ribosomal protein/NADH dehydrogenase domain / Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain / Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain / Zinc finger C2H2 superfamily / Zinc finger C2H2 type domain signature. / Zinc finger C2H2-type / Ribosomal protein L11, N-terminal / Ribosomal protein L11/L12 / Ribosomal protein L11, C-terminal / Ribosomal protein L11, C-terminal domain superfamily / Ribosomal protein L11/L12, N-terminal domain superfamily / Ribosomal protein L11/L12 / Ribosomal protein L11, N-terminal domain / Ribosomal protein L11, RNA binding domain / Ribosomal protein L9, N-terminal / Ribosomal protein L9, N-terminal domain / Ribosomal protein L28/L24 / Ribosomal protein L33 superfamily / : / Ribosomal protein L16 / Ribosomal protein L20 / Ribosomal protein L20, C-terminal / Ribosomal protein L21 / Ribosomal protein L17 / Ribosomal protein L17 superfamily / Ribosomal protein L17 / Ribosomal protein L21-like / L21-like superfamily / Ribosomal prokaryotic L21 protein / Ribosomal protein L24 / Ribosomal protein L3, bacterial/organelle-type / Ribosomal protein L15, bacterial-type / 50S ribosomal protein uL4 / Ribosomal protein L10e/L16 / Ribosomal protein L10e/L16 superfamily / Ribosomal protein L16p/L10e / Ribosomal protein L24/L26, conserved site / Ribosomal Proteins L2, C-terminal domain / Ribosomal protein L2, C-terminal / Ribosomal Proteins L2, C-terminal domain / Ribosomal protein L2 / Tetratricopeptide-like helical domain superfamily / Ribosomal protein L25/L23 / Ribosomal protein L30, ferredoxin-like fold domain superfamily / Ribosomal protein L14P / Ribosomal protein L14 superfamily / Ribosomal protein L26/L24, KOW domain / Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A / Ribosomal protein L24 signature. / Ribosomal protein L14p/L23e / Ribosomal protein L22/L17 / Ribosomal protein L22/L17 superfamily / Ribosomal protein L3 / Ribosomal protein L13 / Ribosomal protein L13 / Ribosomal protein L13 superfamily / Ribosomal protein L3 / Ribosomal protein L22p/L17e / Ribosomal protein L4/L1e / Ribosomal protein L4 domain superfamily / Ribosomal protein L18e/L15P / Ribosomal L18e/L15P superfamily / Ribosomal protein L4/L1 family / Alpha/Beta hydrolase fold / Translation protein SH3-like domain superfamily / Ribosomal protein L23/L15e core domain superfamily / Thioredoxin-like superfamily / Translation protein, beta-barrel domain superfamily / Ribosomal protein L2, domain 2 / Nucleotide-binding alpha-beta plait domain superfamily

Component:

Flagellar attachment zone protein 1 / Uncharacterized protein / Ribosomal protein L9 domain-containing protein / Rhodanese domain-containing protein / Large ribosomal subunit protein uL11m / Uncharacterized protein / Ribosomal protein L3-like protein / C2H2-type domain-containing protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Large ribosomal subunit protein bL20c / Peptidyl-prolyl cis-trans isomerase / Uncharacterized protein / Putative ribosomal protein L14 / 50S ribosomal protein L13-like protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Phosphatidylethanolamine-binding protein / Uncharacterized protein / 39S ribosomal protein L42, mitochondrial / Large ribosomal subunit protein mL43 / Uncharacterized protein / Uncharacterized protein / 39S ribosomal protein L28, mitochondrial / Uncharacterized protein / AMP-binding domain-containing protein / LIM zinc-binding domain-containing protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / KOW domain-containing protein / Large ribosomal subunit protein uL23m / Peptidyl-prolyl cis-trans isomerase / Large ribosomal subunit protein uL22c / Mitochondrial RNA binding complex 1 subunit / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Uncharacterized protein / Prophage protein / Uncharacterized protein / AB hydrolase-1 domain-containing protein / Putative 50S ribosomal protein L17 / Large ribosomal subunit protein uL15/eL18 domain-containing protein / Ribosomal_L16 domain-containing protein / Large ribosomal subunit protein bL21m / 39S ribosomal protein L16, mitochondrial / Uncharacterized protein / Large ribosomal subunit protein uL4m / Uncharacterized protein / Uncharacterized protein / Putative ribosomal protein L2 / Ribosomal protein L9 domain-containing protein / Uncharacterized protein / Uncharacterized protein / MRP-L46 domain-containing protein / Uncharacterized protein / Ribosomal protein L30 ferredoxin-like fold domain-containing protein / Large ribosomal subunit protein uL29m

• Biological species: Leishmania tarentolae (eukaryote) / Leishmania major (eukaryote)
• Method: single particle reconstruction / cryo EM / Resolution: 3.6 Å
• Authors: Soufari H / Waltz F / Parrot C / Hashem Y

Funding support

France, 1 items

Organization	Grant number	Country
European Research Council (ERC)		France

• Citation: Journal: Proc Natl Acad Sci U S A / Year: 2020; Title: Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis.; Authors: Heddy Soufari / Florent Waltz / Camila Parrot / Stéphanie Durrieu-Gaillard / Anthony Bochler / Lauriane Kuhn / Marie Sissler / Yaser Hashem / ; Abstract: Kinetoplastids are unicellular eukaryotic parasites responsible for such human pathologies as Chagas disease, sleeping sickness, and leishmaniasis. They have a single large mitochondrion, essential for the parasite survival. In kinetoplastid mitochondria, most of the molecular machineries and gene expression processes have significantly diverged and specialized, with an extreme example being their mitochondrial ribosomes. These large complexes are in charge of translating the few essential mRNAs encoded by mitochondrial genomes. Structural studies performed in already highlighted the numerous peculiarities of these mitoribosomes and the maturation of their small subunit. However, several important aspects mainly related to the large subunit (LSU) remain elusive, such as the structure and maturation of its ribosomal RNA. Here we present a cryo-electron microscopy study of the protozoans and mitoribosomes. For both species, we obtained the structure of their mature mitoribosomes, complete rRNA of the LSU, as well as previously unidentified ribosomal proteins. In addition, we introduce the structure of an LSU assembly intermediate in the presence of 16 identified maturation factors. These maturation factors act on both the intersubunit and the solvent sides of the LSU, where they refold and chemically modify the rRNA and prevent early translation before full maturation of the LSU.

History

Deposition	Sep 27, 2020	-
Header (metadata) release	Apr 28, 2021	-
Map release	Apr 28, 2021	-
Update	Apr 28, 2021	-
Current status	Apr 28, 2021	Processing site: PDBe / Status: Released

Map

• File: Download / File: emd_11796.map.gz / Format: CCP4 / Size: 244.1 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
• Voxel size: X=Y=Z: 1.19 Å

Density

Contour Level	By AUTHOR: 0.06 / Movie #1: 0.06
Minimum - Maximum	-0.13466173 - 0.24540125
Average (Standard dev.)	-0.0004535477 (±0.014076321)

• Symmetry: Space group: 1

Details

EMDB XML:

Map geometry	Axis order X Y Z Origin 0 0 0 Dimensions 400 400 400 Spacing 400 400 400
Cell	A=B=C: 476.00003 Å α=β=γ: 90.0 °

CCP4 map header:

mode	Image stored as Reals
Å/pix. X/Y/Z	1.19	1.19	1.19
M x/y/z	400	400	400
origin x/y/z	0.000	0.000	0.000
length x/y/z	476.000	476.000	476.000
α/β/γ	90.000	90.000	90.000
start NX/NY/NZ	72	72	65
NX/NY/NZ	157	157	169
MAP C/R/S	1	2	3
start NC/NR/NS	0	0	0
NC/NR/NS	400	400	400
D min/max/mean	-0.135	0.245	-0.000

Supplemental data

Sample components

Entire : Leishmania mitochondrial ribosome

• Entire: Name: Leishmania mitochondrial ribosome

Components

• Complex: Leishmania mitochondrial ribosome
  • Protein or peptide: Ribosomal protein L3-like proteinRibosome
  • Protein or peptide: uL4m
  • Protein or peptide: RIBOSOMAL_L9 domain-containing protein
  • Protein or peptide: uL10m
  • Protein or peptide: Putative ribosomal protein L11
  • Protein or peptide: 50S ribosomal protein L13-like proteinRibosome
  • Protein or peptide: Ribosomal_L18e/L15P domain-containing protein
  • Protein or peptide: Ribosomal_L16 domain-containing protein
  • Protein or peptide: Putative 50S ribosomal protein L17
  • Protein or peptide: bL19m
  • Protein or peptide: bL20
  • Protein or peptide: bL21m
  • Protein or peptide: uL22m
  • Protein or peptide: uL23m
  • Protein or peptide: uL24m
  • Protein or peptide: bL27m
  • Protein or peptide: bL28m
  • Protein or peptide: uL29m
  • Protein or peptide: uL30m
  • Protein or peptide: bL32m
  • Protein or peptide: bL33m
  • Protein or peptide: bL35m
  • Protein or peptide: bL36m
  • Protein or peptide: mL38
  • Protein or peptide: mL40
  • Protein or peptide: mL41
  • Protein or peptide: mL94
  • Protein or peptide: UA
  • Protein or peptide: mL95
  • Protein or peptide: mL89
  • Protein or peptide: bL31m
  • Protein or peptide: mL76
  • Protein or peptide: mL74
  • Protein or peptide: Peptidyl-prolyl cis-trans isomeraseProlyl isomerase
  • Protein or peptide: mL93
  • Protein or peptide: mL86
  • Protein or peptide: mL96
  • Protein or peptide: L51_S25_CI-B8 domain-containing protein
  • Protein or peptide: mL69
  • Protein or peptide: mL80
  • Protein or peptide: mL87
  • Protein or peptide: mL42
  • Protein or peptide: mL79
  • Protein or peptide: mL70
  • Protein or peptide: mL84
  • Protein or peptide: mL72
  • Protein or peptide: Peptidyl-prolyl cis-trans isomeraseProlyl isomerase
  • Protein or peptide: mL75
  • Protein or peptide: mL82
  • Protein or peptide: mL98
  • Protein or peptide: mL73
  • Protein or peptide: mL52,mL52
  • Protein or peptide: mL49
  • Protein or peptide: mL99
  • Protein or peptide: mL88
  • Protein or peptide: mL63
  • Protein or peptide: mL85
  • Protein or peptide: mL53
  • Protein or peptide: MRP-L46 domain-containing protein
  • Protein or peptide: mL68
  • Protein or peptide: mL97
  • Protein or peptide: C2H2-type domain-containing protein
  • Protein or peptide: mL54/69
  • Protein or peptide: LIM zinc-binding domain-containing protein
  • Protein or peptide: Putative ribosomal protein L2
  • Protein or peptide: Putative ribosomal protein L14
  • Protein or peptide: mL100
  • Protein or peptide: UB
  • Protein or peptide: UC
  • Protein or peptide: UD
  • RNA: Ribosomal RNA
• Ligand: ZINC ION
• Ligand: NICOTINAMIDE-ADENINE-DINUCLEOTIDE

Supramolecule #1: Leishmania mitochondrial ribosome

• Supramolecule: Name: Leishmania mitochondrial ribosome / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#71
• Source (natural): Organism: Leishmania tarentolae (eukaryote)

Macromolecule #1: Ribosomal protein L3-like protein

• Macromolecule: Name: Ribosomal protein L3-like protein / type: protein_or_peptide / ID: 1 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 54.025246 KDa

Sequence

String:

MHRFRVCALG AAFCVARRWR SGGGPGDRRV RTDWYRCYPS LMEEKDRDMY HCYYPYLFDH GDKMSLYPKI PDNPREWQVE QLQTTYDAI REDKYDAFVR LRAKFPELYQ DTYAWDNPPP FGEFNMFYSV RFGMIGVKAF TCKDYDDLGN QFDCTAFWFP D NQIVKHST RNGDVGTDKV YVGAMNVPVE FHKPHVAAFY KAAGVPVKHV SAGFPVTPDA YAPVGTKLDV RHFKPGQEVT IT FQNTDYG YQGVMFRHGF DGGYVWLGDS KWQRRPGCMG AEGQKRIYPG HRMAGQTGAS AETYDGVPVW RIDYKNSLIY LPT LIDADV GTYVKFRDTI NTKGYTLWNE HRGTPPFPTF IPSEEEDLSK LATDEGQLTS PPLYMYFRDE FAAAQLVTQA DVED AKSAK PATAAPKKKV YDLKKYTEAR KKYRKNLQKA RKYKLMGVRT RAHEKQQEAR RAKILKYKRV KT

Macromolecule #2: uL4m

• Macromolecule: Name: uL4m / type: protein_or_peptide / ID: 2 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 50.000664 KDa

Sequence

String:

MYDSRSSGVH DVAPRDGVDF MYEGPQQVLP GAHPLPLFHP DNSVTRPPVS PYLPSPQRPH PYFTTELPEL PHFQTTRPIV YTVGTMKQR IVAPVFDLAN NVTHTRELDP FIFGFYPETE EMAKNLSYWL VRCQNFSSKW DYENREIWRK AKKNWPNTGM G MARVGDRK NHAHPWGAHS KPVKPWNLLM PTMDVKTWSK SNRMLVTLKM LQGKLQIVER LTLPEPTQEA YLQLCRTMGW DV RHKGGGA LFMDGGSRLT PSSEYDRAFF FGSFFNGRNK LVRPTLLCDE PYDYNRTSSK ARTKGPKGQK NPIPINRFNA YDA LTHDTL IITEGALLQL EDEMYTHKLA MLPPHIRAQL PERGFLDSEV LGDVPPALQT VQMEAAARTE EAEQAMYAPY YDNP YHPWQ DEGEASYAVD AVEGTVQRYI KSRKTSWAML S

Macromolecule #3: RIBOSOMAL_L9 domain-containing protein

• Macromolecule: Name: RIBOSOMAL_L9 domain-containing protein / type: protein_or_peptide / ID: 3 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 30.510725 KDa

Sequence

String:

MRRSAWVFVA PWVPPPRHDV KVTMPPPPGG EVGGSYGVST GYSDRLARTP YWKRMALSTY ALRMKENETR YPMSPHREGE YDLRYTVTA YPDHIKHRPL LEIGEAHQIP TIEIPVIFLV NLWDEERLTW FGRQYETVYV NRNVAREELL PQRYAIYATE E AYKLLGLP VVNHSIHEEI PKTPHAYKKL LEKQSYTEER WKYTIEYLFR KYEADPPELQ DKSEDGWDGV EELATSATAG GA GDSLAKR KGPVKQRKAR KIKLF

Macromolecule #4: uL10m

• Macromolecule: Name: uL10m / type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 22.169115 KDa

Sequence

String:

MFSRGAAATA MAKVSRLVSP RLRIIHRDYL TRRGGRTHQR CSAVAVDYTP TYFATYKSDP GQCPRLIDAE AVHGDEQAFW SARRDFYRG GASRSYYPAW DRQAQALIML TREVPRIPQE AAFRLFTLGL KMMLLPRLVA GVELMLPSWV TMNAESVLNE G LEGKVAEA DGDGKATGAA ADAAALPSAS SAGANEDSGS ANAEKR

Macromolecule #5: Putative ribosomal protein L11

• Macromolecule: Name: Putative ribosomal protein L11 / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 40.274641 KDa

Sequence

String:

MLRRSAVRYL KARPKTVNIE PGSNRFLDPN VEAKAKDIFA VPEFPNKAVL HNWRFFIKAG KAATGPPVGQ EFSKLGLKAM DFAKAFNDR TKPHFKDDIE LIVRIQVYFD KSYIFRIEPP PTAWFLLRAI RKKRGETGPV VLRGNYCAYL TLEMCYEIAK M KQMSWGKV EYPPIEVRVR RVVGQARRMG IAIIGIDTVH SSPVKGMTEK QYLEESEKHR KVHMIQYEAL KAKELESAPL IE RLHRPNM APLTNTQLEE GLKDANLLNA LWKSSHPKSL FTQDTRDREM ARRYLNTRGW FKEMTPEEMR VVFLNYRLPK QED HQRQLN MTNGQAQSQA YWSRDAASPQ

Macromolecule #6: 50S ribosomal protein L13-like protein

• Macromolecule: Name: 50S ribosomal protein L13-like protein / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 20.500582 KDa

Sequence

String:

MSKQWLCREG ERWWLLDARG QQLPHVAKIA AQYMTGQHRP DFTPGMMTGD HVVITNIKDA VMTGDNWIRV PITWQTAYPG GKYRVRLSE MYERDPCMVM WWYLKDEVNR HFVRKLKTRT APLEKAWLYE DSVHPHAEKN PRPLVWTDTA TMGWRYKDPT F QRRWSPNQ FMS

Macromolecule #7: Ribosomal_L18e/L15P domain-containing protein

• Macromolecule: Name: Ribosomal_L18e/L15P domain-containing protein / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 43.567301 KDa

Sequence

String:

MLSISAVQRR YRLFHPVHQT VPFHFNPVQS IFPLIYENNL LAKPRLSWKD YEGRKEFDAD HPLPVVGTRL NERTTTHKWS HWDQYINPQ ITQSWMYLTQ TPEYVGPRSG HNVIKMGWMK IGGSWKYSRS YNDARRGFAK GQWQERKMTP RFMLAPRVSA G GPRNRYEG KASFSRLSLS KLLWAVDTGR LNPNETITLY HLRNAKVIAD REVVWPGMVL LAGNVERVPY PLHIELQNAS AK AIQLLEE AGGSFTNVYM SHEGLYQELH PEEFPTFMEQ ELPERKGLEN FATNSRKRGW LAQWYEDESR YAHPGAGRRT AHY IRPPTD RDFPATIEEY ELAKHHQKWH LNQPGSATVL PWHSLNTADM ARRSAGRL

Macromolecule #8: Ribosomal_L16 domain-containing protein

• Macromolecule: Name: Ribosomal_L16 domain-containing protein / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 19.130045 KDa

Sequence

String:

MQSSALRPSS LLRAYHYVHP KTGRPIRQYR KYGDPRFINN EVALIKGLFA LITTDFGMVT QSQLENARLA ILRRMPRGSF ALTMHTDYE EFPVVQKSPE SRMGAGKSNI HHFAYKFTTG VPLFEITALS SRRLNQAEAE GIFLAGRSFI PLQTAVVPRG R VDEYHVFK

Macromolecule #9: Putative 50S ribosomal protein L17

• Macromolecule: Name: Putative 50S ribosomal protein L17 / type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 35.8305 KDa

Sequence

String:

MLRWSRLLRG RPPPVMGHAK RMRFAGVDDN PSVTHKPWDT SEPLMADYGW ERGKLPKFRA RSPFHRQQIA RRMVTELIRK DYVIVGGAR APALRILADH VVELAKAGDT DSRQQLAYFL HDPLMVDKAF DEYPRRFRDM NAKYAMMTRL KGRRRSDNVA M YFVEYKNR DMSDNHKGED YTAGPERFFL PPRIIETEKG IQRPPHMQMA FDRWASKFKT EEFHHWWRLR HAKLRYWGVR NV PHPSDVD PLWTEKEEEE WHNEMLANTS DFEDFDLDDD SYEAAGEGGS QGGSSSLSGI GPEPQKKY

Macromolecule #10: bL19m

• Macromolecule: Name: bL19m / type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 16.695305 KDa

Sequence

String:

MGYTRERTNR HFFVSRANAF FSRLPISRIQ RALAMEAIKK GSMKPWKHTK EQIIGSPITC NFEYNPRPVR LIGTVMDAHT EETSIKGGL KVYARSEEAN MMLWIPAGNP KLKYEVTAAK GSFEHYLDER SKWDEAWLTG RARMK

Macromolecule #11: bL20

• Macromolecule: Name: bL20 / type: protein_or_peptide / ID: 11 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 22.442826 KDa

Sequence

String:

MLRSTGVSLY YRATAELDRL RGMLRGRARL ERKVGLKRIT FLMRTQTRYR VEQKAHWERA IVRKNVDSAA HEHGSGWQHL RNDLARQNL MLLPRTQQQL AQYEPLAFRA VMELCASRVA PPPPPMTAQV PEEAYATRPE DPKVAHPAAR RQLEECVERM L CTGRSDVL QREGPRTTQA WMDAWKEYDL GSAAQK

Macromolecule #12: bL21m

• Macromolecule: Name: bL21m / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 21.037311 KDa

Sequence

String:

MLRSANPTIA KALQPLIEGP KFAVVYCGNH QYKVSPGDVI AVQRLRAPIG SQIALKKVLM VGGPRFTAIG RPLLEHVRVT ADVEEQKRM RNVVSLFSTP GRRRLRWLDA QHAATILRIR EVVYEPTVVG ELDKYDGVLL KDFHADRHPN PVFTANDGYD L YYPKDWNK VEEASAFLEM MEAPPTEK

Macromolecule #13: uL22m

• Macromolecule: Name: uL22m / type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 32.278549 KDa

Sequence

String:

MPKPAPRYNI GLRPAPKRQN VGGQFLATQK HYARELWYKR QYYSTRPFAI QKHMGSTPRI LLDRTLWRSC WLTKSNLPDV NRWEKVVNS QRVTEDRWAL VEEDGVMYQV NWKMYCERLE TELQKAQDQL PQYSFMMKAV PSAWKKLDIE LSVLRGLSVR E AMAQCKLS PRKGHMAVFR ALEVAQQGAE GKGLDKEHLR IAYITCMPGP TDKQVDIRSR GYYAWKTKKS SHLLLTLAED PE MVLPDRT AIPYASLMTM KRAGLRTEPT MLDVPAITAE GI

Macromolecule #14: uL23m

• Macromolecule: Name: uL23m / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 28.838916 KDa

Sequence

String:

MKRLSSHHAI VCGAASATAA STRFGDVVGG GSSCTATSPL FAAQRGRFYR PLVNQGINLW RSRMGRLHKG WTTWEYNRDV IPDPRPFPE PAVNNYFGRS RIWNPIAGKI GLVNRKAEEW GWPHQRPPPT GLRRSPEYFP FFFSRYFPDV EVRLVLDSVL N NETTRPIF HIPQDMSKQE LVNYLKNIYN IDNVVRIRVR NMRGRRFKNE VGEIKSLPDY KVAVVELDSP VSIVFKQIKG TE DTPDNKP AAQIT

Macromolecule #15: uL24m

• Macromolecule: Name: uL24m / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 53.621793 KDa

Sequence

String:

MGCVRVRTGC RIRCVRASFT YTQAQMYARY RTRSRFYKRP EKMLKAYNVS PNLLRLPKVK PGLLKGIYTD EKIDLRDRER LELVESIRH PKERDFYQDH TYHNQWIARD LESHQKIQIA GRYPYFSPDY EIKPWIWYPG DTVEVVSGEG AGQRGAIIAV V KYKNEILV QNVNVQDVVI PASETRPEQV VQREHPISVL RVRHVDPSTN QLCHLEIVKV RNKETGELEE RRISLESGAL LP IPAPEET VEAGDPLKDT AIQDADEETY DREKEMPLLV VRRLQAMENY FVDSLQKSHE YHKALQMRNA QDMQTFQKDV LVR ATEKLA AAAAVAGHGA MAEAGSQAAS VATESSQAGD AEEDAVKGTI TVETVVAEVL KSEQRFRSDA AAPGVPGWWQ NMID AYVSV LEEEEATIEA EAAAQAQAAE ADRRAEQLMA DATAEAGQSM EEDGTMEGGD EDLDEQDGDL DEDASRSDRS K

Macromolecule #16: bL27m

• Macromolecule: Name: bL27m / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 21.610887 KDa

Sequence

String:

MLRITPSRYA SKVTAGNAKN QAGSPRQKAK LFHVIPGTPV TPVEKLKEQR RRFGQDRYSR QPEYRPGRNV RMDPNTFTLY ATTKGVMTI RTSRINPSYK WLDVEPDIQK VYRSRCMRAA LQARGKASMM VAGNVHYRAE LDHVTEPHWR ERVMRVPKAT E RFQDPNYF TRGLVPSLRP LSRYSYE

Macromolecule #17: bL28m

• Macromolecule: Name: bL28m / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 27.222477 KDa

Sequence

String:

MLRQSSLLCF STFALNPETS RAPHGPPRGL INRYISMGLP PWAAWCNRVN RHALYRMSDV SPRSFLPKAP HEMDVIWMNE RVRERVRTS RQVQHVYRQL KYPFVKTGIH YSDTLDHWVQ VPMVEAAMFE IEKDGGFDNF ILKRSGPELR STYGERIRRH L LVRQKETQ KNFVLDQQAK ALAEVTQAEL MKATSEEELD AVLAKYGMDA EEFKRLMAKR VMEQRKSVAA AGLRSK

Macromolecule #18: uL29m

• Macromolecule: Name: uL29m / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 54.235465 KDa

Sequence

String:

MRCSARRANV AALYEFVDGN FLNNKRPAIP GGAWPLESLR RKSLADLQQI WLSLLKERNM LSTIKEHYLR HQEELGAMPA PSRLKMVEE SMENVKRVVK ERDAEATAEA VRIFKERLAK GIYRYPPGPP PPPGAHDPTS TVKLVLSRRV DEERLRELLG R FNVFEAHK GIVKLTMQLP EDVLTQKRDA EQLWQQYMAE RRNVEEYYKW PGSSTGSAES ASVYDHTVVE LAPGVYSGHR GT SAIESNC VDDSNDGAHG VVQAARLPVP PPKTRPPPPR NPLEHIKYQQ RSVLSKAVIQ LGYFPNITTT APRFTKADDV PRP VHPDEI EGPWEVRVTY DAKDGLAYVQ SLSLTSIDGA AVLSVEEEFP AAAQPYAAVD PVYQEAVRRE MAQEETLMKW PNVP KWKYQ YDLYTKKHLA QVVQYNYSNV VDYVDREVLL TGRSVWESPI DIDPTCGGMK SVPAHAKKPK RYMTHGLAEV GVTDI

Macromolecule #19: uL30m

• Macromolecule: Name: uL30m / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 45.564957 KDa

Sequence

String:

MRRCVMAKGE DPAHVAGWDD RQDAVEWWWT EANDSRGRQR LEAAAAVAAA AASSTVGLPL FPRFSPGRRR RRRPPAPPPP PPPLFLSRH LHSMPWLWCT CVKMQMYYTP TALTCPLSNS LAAHVGHIIV GVAALLPYSM LLFLTVMCNP RKHEPVLRAQ R IRWLTFHS LMFRLLRCIT ASPAVAASVA VAAAQTPTSL RPAAVCRRGV HLAPSVLAAS APPPPPQQQQ QPTSAAVPAS TA TSTTTIA AGPYRRVGNV FIVTCIDHPF KFSWEVNRML RELRLEFMGQ TTVVPDIPPV RKRIWRVRHV VRVDQLDLDE AKA LIGIPE HISFRDLAGQ IPPTFGRGGS VANPHMRSKM NFMRLRRMRL RDVMHRDQLE KRLLEERHHA LQQQQQQQQG GGEA AAAAA ATTA

Macromolecule #20: bL32m

• Macromolecule: Name: bL32m / type: protein_or_peptide / ID: 20 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 9.865692 KDa

Sequence

String:

MLQRTTLRCY SALVGQATPV LLGSKGGTPK RKKNPMQLRR KTYGLHFKER YLKLEEWYFC PLCAEPKKQG EWCRREDCRQ IKP

Macromolecule #21: bL33m

• Macromolecule: Name: bL33m / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 13.473062 KDa

Sequence

String:

MFRASCTLLG HGQYKTRLKK RMVGFIPKVI PRKIRNNMVA LRSEANTGHM EGYIKTEAER LDATGRKLQK TMWDPVLQRY TLMKETKVR GPFLTKSNIA RKVDFPVGAL HGTKLGGKK

Macromolecule #22: bL35m

• Macromolecule: Name: bL35m / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 18.393578 KDa

Sequence

String:

MFRISLICFP KAGCEEITRQ GRRVVLKPQE YFAQHRMQVW QMRFKEMGPP FSRVWVALGG KMRRRRIGRQ IDVKDMRYYW RPIEPQYQR LYMSRLRIKD HSNKRVQPMR LRATNNDIGQ ASSLKEWERS SDRKYGAALA PPKKRDFEFR VF

Macromolecule #23: bL36m

• Macromolecule: Name: bL36m / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 21.851152 KDa

Sequence

String:

MLQYTSSARQ ALRATALVLN FFPLGYTCGP KNKQVFFPPN NLDGRTTHQM KKLQGSTDKH PGLVPRDKLK LHCEFCRFHW VQDTLVVRC AAHPKEHNQR EIWLEPTWTW GKQQPYQYYK YMPVNINPRT GMPLAREDAK GMNNERRSQG LPTKTRLLER E RRGISRAI TGLGIYNQRW QTRFPFAT

Macromolecule #24: mL38

• Macromolecule: Name: mL38 / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 58.116398 KDa

Sequence

String:

MRRFLPSSVA AWGAGRVLQC AAEWYHMPGW KTQSSTKDAR SREQRERDRK ARQIEKLPRP EALHDFQYPY EKTILSDSMF EYPVYETEL DTPQLFNLTP PPDFFIYWNA TDFDRTAYPP VPEDDHRVLV PSSQSPRWIE HRARLLQYLR KHEIMPHYVP H IHANVNLS VVFPGQYNTR ARLTDENGDK IPPPPAQTKM TPRNFWFTAH CGNYMELTDV QQPPSVFFFE EAPAAASAAS DA GEAGDAA NKQSSHAAVN YYTFVMLSPD YPYRVPLLQD RHKADRGFFL NYMVANLRAP QAVSTVDGAV VDTEGLQSKG DVV VPYVAP LPTEDAGTTR HLCLLFKQTG HVPSVKPMTA TEEQRDFPLA QRSNYRLHSA LTKQTGLKMP PSASTACLAS LRSV ERAIP ADPCAVSFFT TKWDIQVQEY YEKVGLPEPA APVDEEIEAL LEFHAMRPEK LRVRARHRPD GSVNMGDDPN FWAQA LPTR AMDGSMQRGL GWSRRTTMGA NGVPVVYPH

Macromolecule #25: mL40

• Macromolecule: Name: mL40 / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 33.207035 KDa

Sequence

String:

MWTLSRPCLA AVRTAVLCQK KQTAAGYMAS AGKVGNEEKW AQAAMEYIHE KNHVNDARKR QQDVDQERSI ANAYDRYSAV SEAKFDERL SRLIARMSEA LEEMRNLGLE EALEEAVLLN SEQPPGHYRR PSLTPPLAGY EPGFGLDVPQ LRSQQAEYPP L RRPTDWLE FGEGGADDFP YVDTHKIEDL TAKHEAQLEE QHGVLREAAP LTGVEGEGWE AYVALHRKAL ARQHLIMDLH ND PELRDKY NADEAFRAAE WERRGMGALS IEAPLERDLE LHYAQVPAYE AFRSH

Macromolecule #26: mL41

• Macromolecule: Name: mL41 / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 22.673082 KDa

Sequence

String:

MLWCTGPRRI VFHNAPSVYP FTKPFHDTPY DQDRGRFDKT KNILRENKWP AWMDHGADGT GFGIGLNRTH PLSKLRGNLR RNPSEIPRV LNMMIQGVWH KSGNKLYFRG GKPPNPSTHP YLTGEPCPVY GWKVTDPGVI REFNLPQPED KTRYKPYVAL Q ERKIMGMQ APTKEHSAAS TSAASTDSKP LMKRLFFWK

Macromolecule #27: mL94

• Macromolecule: Name: mL94 / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 17.88541 KDa

Sequence

String:

MAQWIPKTAW KVSNLNKRYG APYVAKGYAS LDPRCSLDAY SSFQQTVTSA DMKKALLSID STSSGALVID VRSEPERRLR PLLSPAIVA LHPHDILSGA ACPILPSNKE RAEMFVVASE AQRAVNACTA LRRWGFSRVT AVSVDAVSEA IAAVQKPADA A TSSSTKS

Macromolecule #28: UA

• Macromolecule: Name: UA / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 17.294268 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)

Macromolecule #29: mL95

• Macromolecule: Name: mL95 / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 18.694562 KDa

Sequence

String:

MLHRSCVLVD SFKEHYHRVH LPRRLALQRY IKREEARLSR HKGKAVAAAA AAGVQPGEVA YKYNRWWVSN DHEFVHQFAF VEDPDVTRE KRNTLPLVTK ENIWKEPQQT FFLPFAPFVR VVDYAKDPDT KFLKPVNIPR WKDYMQRTKP IVPRTWY

Macromolecule #30: mL89

• Macromolecule: Name: mL89 / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 21.557305 KDa

Sequence

String:

MSSGAVGRGS FHSVVAGANP RRIPTYYNSA YELIQLHRAH REVTRNFLVR DKVFDNKFPG CSLANGLFKM VPNKRGNFHT RELTESIRH RTIWGQRIQQ QRTINAAILE DATKVLSPAQ MEDRFSYRTP DAAAYFSPQE YTAANNWPNY WQHPTEKHVV P KPRWRREP ELGGITRVRD AVATPIADY

Macromolecule #31: bL31m

• Macromolecule: Name: bL31m / type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 21.261852 KDa

Sequence

String:

MVLNKWAAVT KSAPPAAGLR PLARTVSPNP KLRPADYKVP YVLRTFIKDR HSSEMQHIEN RGMYREELAI ERSRFPRMQK TLTIQTDGS LNEREFEFAV PPVVMLFQDR LSAHRQRQVA LAKIGKLKRV KSWETSVRGK ESLNPVCNAL VFPYCVPKKM L VRPRIVDP LSAKSMADNR RSRDDPS

Macromolecule #32: mL76

• Macromolecule: Name: mL76 / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 38.656633 KDa

Sequence

String:

MLQCTALVLK SQHKNVLRKG RPHMQKYKEL NRWQREAQGI TKWEQGHSHR PQPYVERFNP EGAGLTRGTS AYAWKWWHTQ YPWLPNVAP ADYVPPSPRG IRPAAWDDEF ADVVLSMSDE EIQSYLLDKL TEVIFAETQR DGYELRRLDF EGKPLTELPE R RIIENFVF EEETLRERVL DRVVEGVFRL VPTSTDRLEL KSVANIIDFV LTHVTVARKP LQHEIPEAAR TVMRSHPLQP QL GFVHALP TDNRDAVVQE WERMHHLDWQ FGKAVYEPRS AENERGNLTW LREVRHHEAR EAFQADVDSG EARRRHMAKI KAA AQVPHT GTTSQ

Macromolecule #33: mL74

• Macromolecule: Name: mL74 / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 39.392641 KDa

Sequence

String:

MLSSAHRAAF ARPTATLWAS ARSFGAGPTR LLLGLEQVQD VPTSTDRKPT GMHRGPGKRQ TAPKEAAQYQ FIKKWDLQMR ETWDELEPF KGLPKPKVQF GNEAAEVIWP YALLLENVIK VHPYTKSIYV YYSQRQSTPL GELAARVAKR VSQAYLIPIT F HNSHVYVE AEMLLEYSET PWVVVHCLDG THKLIPVKPQ AGQTVKEGAE EVLNGIVSAC NEIGSAVKNP KEVMRLLSER PL QNQYVRV NYQWYGDTPE ERMSHLVKWD YEPEEVVPQL RNRTQHVLDW MNYDGNLPTH NSVRVNIHRE AARMRKPNVS AGP KTFFNS SGSRANARTA RFDNSRSSQS

Macromolecule #34: Peptidyl-prolyl cis-trans isomerase

• Macromolecule: Name: Peptidyl-prolyl cis-trans isomerase / type: protein_or_peptide / ID: 34 / Number of copies: 1 / Enantiomer: LEVO / EC number: peptidylprolyl isomerase
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 28.924203 KDa

Sequence

String:

MRVWVLAPHS LPPASFRPIF EARPPSSPTH SFHLLPTPIY LYITCTDAVD LYVCAVTSLL AEWTTTMFAR STIRWAAGAG HAFMDIAIG SQPPHRVTFE LFTKRCPIAS ENFLKLCTGE NVLPQVSSID GIGEPSFRDQ FLPQLTYRNT TVHRVCKGYL V QGGDIVSG QGTGQLSIYG ESFDAPEEVK ASKFDRMGLL GTAVSAPHLN GSQFFILTAD KAPHLNGTCI CFGRVVDGWT VV KAIEAIP LTAAGEPAER VVVVECGKL

Macromolecule #35: mL93

• Macromolecule: Name: mL93 / type: protein_or_peptide / ID: 35 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 18.858525 KDa

Sequence

String:

MLRFTQVIRK NPVVFKQGQG MFSHQLKRIL NKKSLHKYNW DPLHMYDPRK LVHANRYVDH DTYEEKYDPH WEHNAHLVPD QQFYNIPVP KEYKDAYWWR DLQARRVQCP TEWVHFRMHT KDKLKYDFQD LAFRKKFEYS YEDVVANAKD MCS

Macromolecule #36: mL86

• Macromolecule: Name: mL86 / type: protein_or_peptide / ID: 36 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 21.071691 KDa

Sequence

String:

MRPSALCLGG FTMKYKRGTG LWDEDHVNDF DANKYLSARS TMRWYYGMER LQTRNNMNAR RATQSYNNNM GLHHSGRGAF ERELERRGI QVDKYPLTTT TGAARVAEMV LLRRQELEAH AKKAMESQRQ ARRRDAPSEW YDETEGPLNP RFLASMQSNY T QVITELPS SPVTGRRELP GASFA

Macromolecule #37: mL96

• Macromolecule: Name: mL96 / type: protein_or_peptide / ID: 37 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 16.713799 KDa

Sequence

String:

MNDIYARRLA QTSMFHQLMR SHGTLWAATQ VTKEKLNLAF VKEEMMRVNG RRAMPLLIGA AANENLNDTH FTHLTEHCAW TESARAFAV QRQTPLTQHI ASMGRMAETI TQAKTASTSQ LLFNEHLARI DGISEFEEEP FVDDEDDS

Macromolecule #38: L51_S25_CI-B8 domain-containing protein

• Macromolecule: Name: L51_S25_CI-B8 domain-containing protein / type: protein_or_peptide / ID: 38 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 31.231971 KDa

Sequence

String:

MSRNGELCLQ RIIVSYSPNK GNPAMRQFMA THLPEFHRQY PQVKIDIRPR QWPESSITGI YRDGSEKAYS IRFLSSMGIN VRFHRLVNE GNDYNHSFSA SHLHLQRRSV QGTWNPYLWN YEGTRARHKP PAQWSRKLTE KEWDYYVQQY GAQMKAEEDT I ADRVRRYT DIPEASTEEV NQRWKEHVMP RLQTDLEYNL SHWKKQHRTG AGRPAPPTLN EYSLFSVPDH SSLGQDAIDM LR RREAQRE EDWWRERKGQ LKPPE

Macromolecule #39: mL69

• Macromolecule: Name: mL69 / type: protein_or_peptide / ID: 39 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 54.183988 KDa

Sequence

String:

MPAYSEVKGT CGTPVLDQLI GYYVNIQSRK MYYKDFLRIE HQAVRWAFAD IRKNSEALAH GLLQTGVRPG DRVLAIQPCN CETFVLQLS CAKIGALLCI VPQDTISADK LRFYLNEFQP RHLVAREWIN VPEMKQGELV ERNMHFWDTI YNVIPELGLS Y PGQKFQWV HSQEFYYLKK IIITDHNMNL LGVTPMRKML VWGPFSYYEQ RLRRLSALLH PDDPVLALED PNPAMEDKLH IT YSHRNCV NAGFLFGQLM QLKAETRFGV MPNHHTDPIG AIIAPYAALT SGAVLVHIHS DMFTDDHAIN GIEKLCVEEV ETL VGRKAD FDLILKHAGN FDADQFEHLR SVVIFEDGIE APVSEEYLNK LSKALSLDDV YVFRGPIEAS YMLTWRTLKK GSQG MVPHV EAKVVGDRGT SDAKVLVAGT RGNLRLKGPH VTAGYYNNAG LMTELIDEHG FASTSREAMI DGKDNITLMS AQTY

Macromolecule #40: mL80

• Macromolecule: Name: mL80 / type: protein_or_peptide / ID: 40 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 27.945424 KDa

Sequence

String:

MQRCLARLFQ AGVHTPHGSR YNAARMKNWP VQEVPQNFNF TNEQRFKAKA VPRDTGKIPR DFLLSVLYRN QPCEVASLWE HCLHDPQIV LDSKRHLREV LQQARAEGFV SFEKDAVTDR WVCHLTRERF EEVRALVGAR AEAQDLYSGL RGASATETSA Y SESFREMN EDTKREHFRL LSEQVADTTT HLRKFQRMEM DYLPYTDLNG KVNFMWWYEM SDTRDATALP EAAAEGSPKL SE

Macromolecule #41: mL87

• Macromolecule: Name: mL87 / type: protein_or_peptide / ID: 41 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 22.265654 KDa

Sequence

String:

MMLQHTSLLC RKALQSYPVP PRARNYERRW SSSRTNPYNR MFWRTVLNED FARPSFWVSD FRHKYLAKHG MDYQGRVPAS PAPGMYQGF SDVHKILANH PKPQRESRHL PVMPMTPRVV FEHAQEKRID YAKKMHRDRR LVEQLRTHEF WGWYMKLQRV R GRWCKEHG VSSRGVYGPA VDAAELWG

Macromolecule #42: mL42

• Macromolecule: Name: mL42 / type: protein_or_peptide / ID: 42 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 22.170172 KDa

Sequence

String:

MLRLTQAVLR VQSHQKKRAQ HPNAGTRFGR VYNRGFVRYG FGGFGMSVYS SKKDRTFKVM PVPPPPPATT AVEQRDDFAD NRGLSATTR TLSPTFRMFA LEDGGVLVSH PSHAQIMRWN QRVHTEEGKA ANSTVMDEYV NSRIQAIIAD NTIENTSLSQ W RKAHMWNV IKSHGKLQRR WGTPDFVMGA RSTLYNN

Macromolecule #43: mL79

• Macromolecule: Name: mL79 / type: protein_or_peptide / ID: 43 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 33.388719 KDa

Sequence

String:

MLRTTHVSWA STAKGYMNRV MVYAHRRRKA RYLAPKNAHV RSPLAHKMPE EYGNTWDPRS GVEWHNRMRN RNHYRHWPWA RWTDDPVRF HQDSVCHRTV SALSTVANNG APEWDYYAEV GQAYETPSHF PLSYTAPFIY QYTAQCWSRE DLQSYLERIE Q SSGLRTIA DAASRREALY TWWHNAGMNV IPLGVLQHLE LVSRDIVAQN ARKSYRIEQH ERGILRTPEM ERYYALPHLR GP SMPVQLA QPSGKYPSGK FTQMMEDVAI HPLQKPDARY KHNMYPA

Macromolecule #44: mL70

• Macromolecule: Name: mL70 / type: protein_or_peptide / ID: 44 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 50.752273 KDa

Sequence

String:

MSVFPGLCGD VATTNYRVFL GTLPNLAVEE RFLRQVQPVF PWYASRKHVK EQASEFLEID LASCDPELLL RYTHVYYVRR QLYDELVDR QLTLMETGKA AKVADSALLT CLAQVNAAIT PRLQYELHLL QQAKKACRVP RRRELNPDAA LEAHDYLCMM R VVEEDVGG IPDAEMQARA YLPREVLEAK VKELAAMIFG DGGSATKGTG AALERKEQKL LQRMIPADYN KVGAVEKLRP VD VTALYRF TGERVCGRPA DKPFARALWG HVFRKVGSHP LYLQRASLYW ARHSGLDPQS ATSAMPADLA TAVCVQQALF PAL KYRCQY LYTSPDIARQ QWRTGHVVPL LRLFPLLGAP AAEDLAAQLV VEGEWAKLGI EADTNLLHDT VLRQLKDMVE QVSA LYESD AGAVLKRVED GAKVLCPSLS ERESLTMRGA PEDTSREVSA AAAARVANAA PA

Macromolecule #45: mL84

• Macromolecule: Name: mL84 / type: protein_or_peptide / ID: 45 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 24.621238 KDa

Sequence

String:

MLRWSRLLRE MAPELQLEYI PIIFTRTILG PQGGFAGEER LIKREVAQKY MSEGNAVTPS AEFHQGVWCY NPDSEQYDRF VERNAEFLD FAARKRQWLD VYWRVNTGYL LFGRQSWGQG WLLNCPLRKK DIAQKLWEQY KVRVDPRLIE FREKDRRTGI Q DLGHNWCW LYLPGAEELA IDREVYDNKR VKVRMHIRKM SSYGALY

Macromolecule #46: mL72

• Macromolecule: Name: mL72 / type: protein_or_peptide / ID: 46 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 56.554801 KDa

Sequence

String:

MCTRVFDVSQ RFILLVSLPP LSLSLRPSCC SRKAATRRRR STASVLLATD ALSLFVRTHY PSPLLFLLLP NFPLPIHSPR KQMRAAVGA VLQPSSSVGA LRCQARFITR LYTSYFKGEL FPNQLARPLE RLPRGVSLAA ARKGQQAAAP SSSGSGNPAT T ASLDVVTW GDVDSTDLVH ANEQSRAVAP QAGLAPRRPY VPLGEVAKLE LQGDYLTEGG LHQEALEYYG VVAKAYELAY PK DHPQVAG IRLKLAGAFR RTGRLTSSKA NCEAVLQMLD SAVQPPLELI VEALFELGLT SEAMSDAAAG TVFEEAVALV DMF HNSGQS HKMLRLLPRL GRRFNLNFEE KFVYFSPFDY DRVFALADQC LERAEVFYQA RNDRAGVMRV LQQRKELIDK KFFN MRDFA GRIHTMRGHW KRRAQVLTNA PTPDELLRYS PTIHQVYRDF KYELNAPIGR EKEVQPGVNR VVHDMGNPYR RSGVR SQRM FRDAEKNFEK YIRADAFEA

Macromolecule #47: Peptidyl-prolyl cis-trans isomerase

• Macromolecule: Name: Peptidyl-prolyl cis-trans isomerase / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO / EC number: peptidylprolyl isomerase
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 25.314658 KDa

Sequence

String:

MWRLSRVALQ SNRAALYMPY TPVATNPVVY FDITAEGDAL GRVSVELFRD VVPRTSENFR SLCTGERGYG QCLLYYKGTP FHRIIPGFV MQGGDILTKD GRSNVSVFGY PFPDESFEGK AGKHLPGTVG MAHSGPNQNG SQFFFNLGRN EQLDRKFVVV G QVLGGWEI VNQVVKLCGS RCGTPVSRAW ISDCGQSGGY MAEETQEALQ GERAQHVIPG KEVLDLIQPR Y

Macromolecule #48: mL75

• Macromolecule: Name: mL75 / type: protein_or_peptide / ID: 48 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 39.654387 KDa

Sequence

String:

MLRRTEIALK KGWTHNPGHT RRGGKNLAWR PKISDAKLSQ FVPLALVHPR RHPNNWQERQ FNALGYTKWP KDIGFYNAGD NFEVTPEAA WRLYVHARDE PYWGKLHCEK TIITLLPVVE KAPKENMERV LDVFRHYLKR YGADHYIYNA VMQAAAFAKN Y EQAEQLFK EMETLGLEPN AQSYVNMMLA AKLCGLPPEK SEAYFKRAVK DGAMQSVMRM DTEFRMWMDQ LDRLGSFTAS SG YLSVNEE GAKPMPRDMW AIWGWHRSES KFISRRDLIM QQVRARVHSG KELVGTVYTK TRRQPWAKFN GMLRHDYNGP SYR APTIFP DAPEYTNEAG HKAF

Macromolecule #49: mL82

• Macromolecule: Name: mL82 / type: protein_or_peptide / ID: 49 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 37.905758 KDa

Sequence

String:

MLYGGSRVQY LVQPPFTLHK IRSENLPPPS LYAERHDLGL EMQLPRDMHV YNSINMAIQR QVGGDSSTLD GEQQQLQGGH ADGFDMGAF FTEQHHPERH HNSSLPYAKH DTNNVLAMRL FPVNVGVRAR TEAIRIRTDD CLQRLRDADL CAKMRLPLEH P LPLSRRSQ YAAIHRVRQE RCYDAPTEAA GERAAAAAEE ASRTAHLRGA AAHPPPSELS IVTRPVDRLG SHSGSSAAAC TA DADHLSF PVHPFAAAAV SSGCHSARSG SAARLASQRW LPLQTLKPMG HNWSAATRSS GVRGPHMQLM QERLDQKGFG WKR KSRSLW QQDVATAGFR PHRYF

Macromolecule #50: mL98

• Macromolecule: Name: mL98 / type: protein_or_peptide / ID: 50 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 13.262987 KDa

Sequence

String:

MLGGLRPLAA ATRRTVGGAL VSPALITPSR ALSVRTEDFF SKEAVSHARR VSWAPHTTEK KVGAFAKLSR SNFNDPLPVS FQSEPYFEE EIEAYRAHHR PDVYVYKYNV SPTHLSLRE

Macromolecule #51: mL73

• Macromolecule: Name: mL73 / type: protein_or_peptide / ID: 51 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 36.084492 KDa

Sequence

String:

MPTTVLYHGD QLGPRPLVIL DHSVARLEQS ATAVLDACQE AAKRYEAMLS SLAWDHGAVF VPLQVSIGEI NVMEQSCRHV CAVLDAMDV QWSHVLAHSY GALVAARMAA STAYPHRIGS LLLLDTPLVT EQLVRNTKQR EEIAKAKKDV NVPPAELSFA I ESLRSALE TTLPYPAAVD KSLYEDHLFS SASVFREKGL VRDEHRYVPV RHLAQVHHPL QLLVPVKQPI TDVAIHREFF GL RRPAVIK TADNHEDLFS AKCADEVADV VRAWMQRFEP DVVMKRRFEK AAKEMVQLMG SSASFGEKGG GNIEKSEKKE KRK GRQ

Macromolecule #52: mL52,mL52

• Macromolecule: Name: mL52,mL52 / type: protein_or_peptide / ID: 52 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 29.196033 KDa

Sequence

String:

MRRRDWCGVC LPAATLHALA RRYSEYRSSY TGARSAPWAA PEAAPAYPSA RSPFPLERPR FRKTHIEWML HHGHGDRYGK YGPSREIAD FEYADGTPSS ISGKRFALKH HQDHLLVQLI RSAAIVERFE EEELLPRIPG TPEQRSWDPE IPLFLEDVDE F GRPPRPVA GNMVARVIEE RFAQESGRTP VNLANKHAGE VLEPNTMFAT YDPAAFVSDD IKKDVRRPFW SRRRWALSDN FM VPMSPKP KNTIKDE

Macromolecule #53: mL49

• Macromolecule: Name: mL49 / type: protein_or_peptide / ID: 53 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 26.212061 KDa

Sequence

String:

MQPRRMAGHF NPTPQANSLA ATHYAHTPEL RHMADGAAMS LSGQRIPLLK PTLSKWSRQL RSDIYDELLK LPLRYALHDF RTLQAHIHA VPATATNASC TAAAGERLPP GVYHASSGLS SASPDAPAYY AVAGRDSAVG YAPPLGPADP VDVIPFFVHR S SNGHLPGK VYSMNAKTLM PAFYMRIQNI EGDMFRFEEE LMKIFPTKKI FVRSHSVYVY NVNLDGRAVL HHWLLGLGF

Macromolecule #54: mL99

• Macromolecule: Name: mL99 / type: protein_or_peptide / ID: 54 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 13.048815 KDa

Sequence

String:

MRRTVRALYN SFERGWKDKT VHPLDRRGRF NLDEAAAELQ LDEAYVASLY KPLHYTYSMK GQRYPAEQGR TSRPGSLAAS RDRMFPLYR RNYKLNRELR VLDHRRISTD

Macromolecule #55: mL88

• Macromolecule: Name: mL88 / type: protein_or_peptide / ID: 55 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 22.340785 KDa

Sequence

String:

MFQRTCTPRL LACTSALLKR SGKPSDLPDY KQVYLPYDTA PTKTELDRER RKFMHAYSGR MEHRKMVEVK DVPQNMYTYG KEGMSIPIS IFKDQADPVI GPEWTYPGIF ENKIVAQHWY MEELFDREKS NTFESPWQRQ VLDNQVKRRL GKVAWRMSML N IKTIDIFH KERGASKRPG AGDTKAPATP AGKK

Macromolecule #56: mL63

• Macromolecule: Name: mL63 / type: protein_or_peptide / ID: 56 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 18.099469 KDa

Sequence

String:

MLRRSPVPRR YRTAWRELLH PLPVWARRQQ WLKRDTVEMN EAILREPYYR IKTFAQPAAF VSPRVSESAA HEPDTQQSSR YGVDRQLRG PRRAVSPERL QELREQLQFV GSIGPKVPPA AGAGTAYQDE YGTRLRPRYP QSWDTVPPHQ PSRSEI

Macromolecule #57: mL85

• Macromolecule: Name: mL85 / type: protein_or_peptide / ID: 57 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 27.526311 KDa

Sequence

String:

MRRLPLFCRR PSRCCGATAS GSGSSSAAVL AASAAPSVLV LAARGIATSG RVTNEDRRWW LVHLECAPDV TPGTFVSWLD CCGTHTTKK LIERNIWTIE QVAELDSDRV DELKYKEGCL KMDVVWEHAR TIITPLKQRE VSGGVESQLQ SRILELRKKR E LERQRELL ARERATVSDK REETLRRLRE SVAAKKAALR KKLDEQHGEA TPAASESAST EAHRGTAEAA VEDEAVGNIV DR MSGGNPP RA

Macromolecule #58: mL53

• Macromolecule: Name: mL53 / type: protein_or_peptide / ID: 58 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 35.479988 KDa

Sequence

String:

MTAPASHYTF ANLKKLGLCA PQVALSRQPR LRPHVGHLNG LVYPLPYYAM WRGNHDKYTY NQATPARWGE GNTNTMYHQH YAHAKCPTD YGRGGREFQF LSVKRGKLKR KPLPTVQYVD PNSKPQWVFK SWHNPLSAPS MWEREVQYPE HTPAHTGAKR P LAVVAPKT SHKHLFLMHM EKVTVTVSPL LFGYGHTLQK AALDFYRRGL SARSPFPSDK MFLYYSIDHI TPKIEVTWLD GS VYVPPLI EGVKAQDLIQ MVMEQAWLAA DRMSAEGRVL NPIAIDDYKW EQLIAFKQKR AKGAEAAKGG AKKK

Macromolecule #59: MRP-L46 domain-containing protein

• Macromolecule: Name: MRP-L46 domain-containing protein / type: protein_or_peptide / ID: 59 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 33.348551 KDa

Sequence

String:

MRYCRPSRPL VLARASSVLS SSRTFHSQHR TPIIPQVHVH DEPTAQRIHV GYYLHRHPVV KHSPHPLETE MGYLLEREQQ RYSRHESAE SATAFFASRG QTIDILGRTD PNQIKGNFFG LELYQDAMKV VMQRYTPEKR LTSADLWQPN ALGDAPPPRH T LHRKLDDF LYLIVQEGAT GKWTIPHTAR KDDESLRMTA DRAISSQNSE GLDCYVWSNA PQATVFLKDD NTRLFIYAAT YL AGRPQFA SFEPKPKDHA WVTRHELLQY SDTFKSAELL KALLDISADG TFEA

Macromolecule #60: mL68

• Macromolecule: Name: mL68 / type: protein_or_peptide / ID: 60 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 65.792461 KDa

Sequence

String:

MHLHISSIPH RNSNNSKGGV LDATGPMLSA KRGALLLQAY HRPGEVISYK AGDYHLVPKK FTVGKRIAVR SYLDRNRTEL SDRTFMPQK NWFRPYDLQD GCFDRDHERL SYRFYNLETK VIWKAFDTPE LIGMLLHDET VKGNSGMYAP DMLDAALHYT R EARYWRCI GITKPFYDRN TLRAHCWEDN GLQVGTLVMS QAMRHALMDL ERAVRRKELG LEPNYLWDRW GPIGFIDGAR AD YLPRFEH NPYVDPDGVD VTEIDVLPFN THEQIRERYR DFIEPDTAPF EEVFRSPSHG SLTTLADIPN ASVVALYKDL KLK AGTPVA GDAVELAPAD VRTLFYLSAN PEWRAVADGK ASWEEVVDAM QPVQAELDEK IDAARLLQNT RHNAERVRAF FEEK CGFHD FMYTPDKTIT AAVLCYLTEL RRICTETAWG AALAKCLTDM ERVQGMGRDA FLVYRHIEDA ILDKKRRLWA GRFAG ESHE ESTLDYLLEN FGRRAERPRN VGTTGVEFDR EQEPIGRQVQ RRVLDSDKAN KLAEIRRSRG KMWSKKRSVF DALHEK QLQ NFNYGVH

Macromolecule #61: mL97

• Macromolecule: Name: mL97 / type: protein_or_peptide / ID: 61 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 12.078795 KDa

Sequence

String:

MSNRFFQKFY LRCGNCSAIQ RSAQGYQPIA NPILFKSDEH CRNYHDEQRR AAGYSGMVVT CRCHRCERVH SNWKVLDAQQ FLDAKLRMT PEERAQRLWV SKS

Macromolecule #62: C2H2-type domain-containing protein

• Macromolecule: Name: C2H2-type domain-containing protein / type: protein_or_peptide / ID: 62 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 20.926838 KDa

Sequence

String:

MLRIGRTLLA EVTTINSTTA SVSGRLIRIR KKSKWIDRRS TRVPHNGKDI WYFGDQPSCA LCHIRFRYKQ DYEAHKESEL HVNRLRWVE TMNWWRETGE PAYLKASNEQ WEWFEQHVLP TKAQEMGCTL DEARRVYRQA IMTETPTWHR PLQCPTVKQE V QEPRDQRW PASPKW

Macromolecule #63: mL54/69

• Macromolecule: Name: mL54/69 / type: protein_or_peptide / ID: 63 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 28.602615 KDa

Sequence

String:

MAFRGSSARL AATPGVGIAP ETTPVKYVPE MLNIQNAKWW NGRGKPVYRS TYNEKSWLEK ARWGAFTKGS RPVMRQRYSA AALKEALEM VPEGFETCDV PRPPQRIRAQ SEGVVGRWYT NYWTLHSVRY QCQLAGVEWQ FGERQRPRTN YDEPHMYTDF E ETKAIRDY RSRWINVNRS LVGMSRRMKE SEEEARYLHF KKVQDTFWSN RKVLVNRIKS MHNQGTLQSA KDLPIKTINI KA FLAE

Macromolecule #64: LIM zinc-binding domain-containing protein

• Macromolecule: Name: LIM zinc-binding domain-containing protein / type: protein_or_peptide / ID: 64 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 25.173934 KDa

Sequence

String:

MYFYRRIPSL ASKMNHMRQF SLPRSSAAII MAASTAALAV PCRAMHGKPA SGHKVRTQHS RRWWMQSKAH HLTAVPHEEA RSRPHFPAY TEDVDQPMVV PDGVCCFNCD KPIDGDDINS YVWVPSGNAR VPTTQGYFFH VKCFKCWNCK YRIIHNQFYS K DSRAWCLS CALGRDIRVP TRRWHTSYVN THRTGSRLTG QFFPRHRHQM EFLFSPKE

Macromolecule #65: Putative ribosomal protein L2

• Macromolecule: Name: Putative ribosomal protein L2 / type: protein_or_peptide / ID: 65 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 43.379852 KDa

Sequence

String:

MASVSPLLMP CRGVKLVNPI GKQGSQHYGL EPKLEAGRDT QLKHTEMYDG YTDDFGVFKE GPPVTLRLEY VRSPDHGYSQ HILQKDIWS PFQVGANMMS YTPLYYDWKG FSSRDYFGHR SGTNPGSKVL LGHYRRDEVR SWGYRIMVNH KPQKRIPKWL A CVVHIPRK KTFLGFFLYA NGAYVAELLT YKQLPRIIYN KAFQGCLPTI GQTVSLTEVT YGKEIHSVEM YPGHGGVICR AS GTAAVVL RGSEPNLVPL LLPSKEVRLF DNMCHAVFGR RAGVMYNKQR NFSKRSVEEN MPHRPKVHSK TKRVSSHPAG GGN GGSPNL LTPLDWRIHP RNCVKTKYWL SGYILRGRQY NRNQTVADLK SKTYSWANRD PVYR

Macromolecule #66: Putative ribosomal protein L14

• Macromolecule: Name: Putative ribosomal protein L14 / type: protein_or_peptide / ID: 66 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 21.633137 KDa

Sequence

String:

MLRFFRARLA PTTTDAAAKL PAGNPVNKTW FRHNLIIRRK GSYRSRWGNG TEGYGAGVPL SDQVKLHCVD NTNCKHVRLI AKATAERFA HCRVFPAVAH RVSVQRFKGR GGGGEVSRHR VKPGNIYWVC LFTRRQTNTR MSGLQTNFDR NTCIIMNDQR V PLGTRVMY CAGRHVNHKY HLKAVVLANF FV

Macromolecule #67: mL100

• Macromolecule: Name: mL100 / type: protein_or_peptide / ID: 67 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 146.807906 KDa

Sequence

String:

MLARYLDPSV HPLRVGQVVA YDYLHAAKTW QWTLGTVREI KDYTAVVQQW GLHTGDIDTL RSILLKEVDT ENGRMKNYHD MLAIAREKL ASIRRSNEDR VSHVRGHFDK AREKVELIDE VDLRKVTAQA APSPVAVAVL KAVWAVAKCD PTAVEFYEWA D VQLEYRKP AALDEIAKTD VLAKLYPSAE SLQQSLEQDP KLNYKAAARD SPVVASLHAW VITALAYQQA YNLLAHDKRI QE QNDAIAA AIAGMKACRA KIAKLKDELS SKDTAALPGQ VTSFTRTSVL VTIPLSAVIS PVNVDTDVKR CVLTKDEVEQ IPI DAKITR YAQKQKLAIT GSHLLDQYAA ATTTHIYVTE LEDRLFFFQH YMASALRDAQ TAAVDAHQRL AVSLHELEAF RQKR HDAKK ARAAEPELAD ADGVEPSSGP TSSRSPTGRA APRGQSAAPR GTASQQHKLL GPAYQSIDPA TIANEPLYAV TIEEY KAKD AAGERAMDEA ERMADEVQRL AVELEDAKAA ADKLAEELAA KDEELAAHRQ KRHDAQQARA SDPALAAADA VAPRSG KGA ASPHVGAVQR QAVDPATVPV APAVIAEEPL YVATAEELQH VRDFADQLAE ELEAFRQKRH DAKKARAAEP ELADADG VE PSSGPTSSRS PTGRAAPRGQ SAAPRGTASQ QHKLLGPAYQ SIDPATIANE PLYAVTIEEY KAKDAAGERA MDEAERMA D EVQRLAVELE DAKAAADKLA EELAAKDEEL AAHRQKRHDA QQARASDPAL AAADAVAPRS GKGAASPHVG AVQRQAVDP ATVPVAPAVI AEEPLYVATA EELQHVRDFA DQLAEELEAF RQKRHDAKKA RAAEPELADA DGVEPSSGPT SSRSPTGRAA PRGQSAAPR GTASQQHKLL GPAYQSIDPA TIANEPLYAV TIEEYKAKDA AGERAMDEAE RMADEVQRLA VELEDAKAAA D KLAEELAA KDEELAAHRQ KRHDAQQARA SDPALAAADA VAPRSGKGAA SPHVGAVQRQ AVDPATVPVA PAVIAEEPLY VA TAEELQH VRDFADQAAH DAATREAEVA GTVENLRNEL DDVREMNAKL EDEVFALKEQ LSDAEDAYKK LAGALVVAED ERQ ELCDDL EAALDELEQK KDEYDELLGN LEEVQGLLEA ADVAGRTAVE ALEQRNRDMA DLQGELANAL DASKENENLR ALLD AKERE IDRLKEYNSF WTDTVGTGKQ KVTHRLTKIF DGDWTRLMRH RPEALKAAFV IDSSNACHVP GDQIFLVSNS FTRRL LTRT DHCPKCDRLS TFRFMSVSGM VGRMPYKPVD TPGPSYATLY WRKQRSGKIA SQPLNEVCNK NEF

Macromolecule #68: UB

• Macromolecule: Name: UB / type: protein_or_peptide / ID: 68 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 5.720042 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)

Macromolecule #69: UC

• Macromolecule: Name: UC / type: protein_or_peptide / ID: 69 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 12.27312 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)

Macromolecule #70: UD

• Macromolecule: Name: UD / type: protein_or_peptide / ID: 70 / Number of copies: 1 / Enantiomer: LEVO
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 8.102979 KDa

Sequence

String:

(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK) (UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)(UNK)

Macromolecule #71: Ribosomal RNA

• Macromolecule: Name: Ribosomal RNA / type: rna / ID: 71 / Number of copies: 1
• Source (natural): Organism: Leishmania major (eukaryote)
• Molecular weight: Theoretical: 2.8954165 MDa

Sequence

String:

UGAAAAUUGA AAAAUAUAAU UUGAAAAAUA AAUUACAAAU AAAAGAUUAA AUUUGAAUUA AUUACAGAAA UAUAGACACA AACACGCCC GAUUGAUUUC ACGUAUACAC UUGUACUUUG UUUUUGGUCU ACGUUUUGUU GUUUGUAUUG GCUUGAUUUA A UGGACAAA UAUAAAAAGC UUGAACACAA AAUUUAAAAC AAUUGGAUAU GCCAAGAGUU AAAAAAUGAA AUUAAAUAAA AA UAAAAAU AAAUUAAAAA AUAAAAUAAA AAUAAAUUUA AAAAAUAAAU UAAAAUAAAA AAUUAGAAAA UGAAAAUUGA AAA AUAUAA UUUGAAAAAU AAAAUUAUAA AUAGAAAAAU UAAUUGAAAU UGCAAAGUAA AAAUUUAUAA UAGAAUAAAA UAAU UUCAA UUUGAUUUAG UUUCAUAUUA UAUUAUAUUA UAUUAUAUUA UAUUAUAUUA UAUUAUAUUA UAUUAUAUUA UAUUA UAUU AUAUUAUAUU AUAUUAUAUU AUAUUAUAUU AUAUUAUAUU AUUAGCAUUU AUUAUAUUAU UAUAUUAUUA UAUUUA UUA UAUUAUUAUA UUAUUAUAUU AUUAUAUUAU UAUAUUAUAU UAUAUUAUAU UAUAUUAUAU UAUUAUUAUA UUAAUUA UA UUAUUAUAUU AAUAAUAUUU ACUAUUAUAU CUAAUAUCAA GCUUGUUAGA AAAAACAUUG UUUUUUCUAA CAAGCUUG A UACUCUCGGU AUGGUUUCAA AAAUUGACUA AUUUUGAUAU UGUUUUGGCU CUGGACUAAU UAAUUCCCCU UUAAUUUUA UUAUCUAAAA UUUGCAUGUA AAGUAGUUAG UUAGAUAUGA AAAUUUAGUU AGGGUUGAUA AUGAAAUCAA UUAAGUUUAU AUAUAAAGU UAGUUAGUCA AUAUGAAUUU UUUUGCAAAC AUUUCCGGUU GACUUCAUGU GAUUACACGU ACUCCGUUUU G UUUUUAUG UGUCAUGAUU UGCAUUGAUU UUUUCGCAAC AAAUCUAAUA UACUCAACAG CACCUACCAA GAGUUAAAAA UG AAAUUAA AUUAAAUUAA AAAAUAAAAU AAAAAUAAAA UAAAAAUAAA UUUAAAAAUA AAAAUAAAUU UAAAAAUAAA AUA AAUUUA AAAAACAAAU UAAAAUAGAA AAUUAGAAAA UGGAAAUUGA AAAAUAUAAU UUGAAAAAUA AAUUACAAAU AAAA GAUUA AAUUUGAAUU AAUUGUAGAA ACAUUUCCGA UCGAUUUCAC GCAUACACUU GUACUUCGUU GGCUCCAUUU AAUGG ACAA AUAUAAAAAG CUUAAACACA AAAUUUAAAA CAAUUGGACA AGCAAGAGUU AAAAAAUGAA AUUAAAAUAA AAAAUA AAA UAAAAAUAAA UUUAAAAAUA AAAAUAAAUU UAAAAAACAU UGGUUGAAUA AAAUUUUUAU UUUAUAUAUA AUUUAAA CU UUUGUUGUUG UUUGUUAGUA AGCAAAAAUA UUUAUGUUAU UUUAAUAUUA UUUAUGUACU UACUAUUAUU UUGAUAAA U UUUAACUUUA AAUAGCUCAA AAACUACAAU CAAUAAAGCA UAAAAAAAUU UAUUUAUGAU UAUAUUAAUA UAAAAUGAC CUAAUAUAAU GAAAAUACUU UGGUGUUAAG UUAUUUGUUU UAUUAUGAAA UAAGUUGCAC UAUUUAUUGA AUUAAUAAAG AAAGAAUAG AAAUAAAUAA GUUAUAAUAU CUUUAAUUUA UUUAUAAUUU CUUUGCAUUU GUAUUUAGUG UGAGUUUACA U UUAAUUUU AUAUUAUUUU AGUGUUAGUA UAUAUUUAGA 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Macromolecule #72: ZINC ION

• Macromolecule: Name: ZINC ION / type: ligand / ID: 72 / Number of copies: 6 / Formula: ZN
• Molecular weight: Theoretical: 65.409 Da

Macromolecule #73: NICOTINAMIDE-ADENINE-DINUCLEOTIDE

• Macromolecule: Name: NICOTINAMIDE-ADENINE-DINUCLEOTIDE / type: ligand / ID: 73 / Number of copies: 1 / Formula: NAD
• Molecular weight: Theoretical: 663.425 Da

Chemical component information

ChemComp-NAD:
NICOTINAMIDE-ADENINE-DINUCLEOTIDE / NAD*YM / Nicotinamide adenine dinucleotide

Experimental details

Structure determination

• Method: cryo EM
• Processing: single particle reconstruction
• Aggregation state: particle

Sample preparation

• Buffer: pH: 7
• Grid: Model: Quantifoil / Material: COPPER / Mesh: 300 / Support film - Material: CARBON / Support film - topology: CONTINUOUS / Support film - Film thickness: 2.0 nm / Pretreatment - Type: GLOW DISCHARGE
• Vitrification: Cryogen name: ETHANE / Chamber humidity: 100 % / Instrument: FEI VITROBOT MARK IV

Electron microscopy

• Microscope: FEI TALOS ARCTICA
• Electron beam: Acceleration voltage: 200 kV / Electron source: FIELD EMISSION GUN
• Electron optics: Illumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELDBright-field microscopy
• Image recording: Film or detector model: FEI FALCON III (4k x 4k) / Detector mode: INTEGRATING / Average electron dose: 60.0 e/Ų
• Experimental equipment: Model: Talos Arctica / Image courtesy: FEI Company

Image processing

• CTF correction: Software - Name: Gctf
• Initial angle assignment: Type: MAXIMUM LIKELIHOOD / Software - Name: RELION
• Final angle assignment: Type: MAXIMUM LIKELIHOOD / Software - Name: RELION
• Final reconstruction: Resolution.type: BY AUTHOR / Resolution: 3.6 Å / Resolution method: FSC 0.143 CUT-OFF / Number images used: 82060