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- EMDB-11458: Structure of a human ABCE1-bound 43S pre-initiation complex - State II -

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Basic information

Entry
Database: EMDB / ID: EMD-11458
TitleStructure of a human ABCE1-bound 43S pre-initiation complex - State II
Map data
Sample
  • Complex: ABCE1-bound 43S initiation complex
    • Protein or peptide: x 49 types
    • RNA: x 1 types
  • Ligand: x 5 types
Function / homology
Function and homology information


negative regulation of endoribonuclease activity / CTPase activity / positive regulation of mRNA binding / viral translational termination-reinitiation / positive regulation of mRNA cis splicing, via spliceosome / eukaryotic translation initiation factor 3 complex, eIF3e / cap-dependent translational initiation / eukaryotic translation initiation factor 3 complex, eIF3m / translation reinitiation / : ...negative regulation of endoribonuclease activity / CTPase activity / positive regulation of mRNA binding / viral translational termination-reinitiation / positive regulation of mRNA cis splicing, via spliceosome / eukaryotic translation initiation factor 3 complex, eIF3e / cap-dependent translational initiation / eukaryotic translation initiation factor 3 complex, eIF3m / translation reinitiation / : / IRES-dependent viral translational initiation / OAS antiviral response / multi-eIF complex / eukaryotic translation initiation factor 3 complex / eukaryotic 43S preinitiation complex / cytoplasmic translational initiation / translation factor activity, RNA binding / ribosome disassembly / mRNA cap binding / formation of cytoplasmic translation initiation complex / positive regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis / negative regulation of endoplasmic reticulum unfolded protein response / oxidized pyrimidine DNA binding / response to TNF agonist / positive regulation of base-excision repair / protein tyrosine kinase inhibitor activity / eukaryotic 48S preinitiation complex / positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage / positive regulation of respiratory burst involved in inflammatory response / positive regulation of gastrulation / ribosomal subunit / IRE1-RACK1-PP2A complex / nucleolus organization / metal-dependent deubiquitinase activity / : / positive regulation of endodeoxyribonuclease activity / positive regulation of Golgi to plasma membrane protein transport / TNFR1-mediated ceramide production / negative regulation of RNA splicing / negative regulation of DNA repair / laminin receptor activity / oxidized purine DNA binding / negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide / supercoiled DNA binding / neural crest cell differentiation / rRNA modification in the nucleus and cytosol / negative regulation of phagocytosis / NF-kappaB complex / ubiquitin-like protein conjugating enzyme binding / regulation of establishment of cell polarity / positive regulation of ubiquitin-protein transferase activity / Formation of the ternary complex, and subsequently, the 43S complex / regulation of translational initiation / erythrocyte homeostasis / cytoplasmic side of rough endoplasmic reticulum membrane / positive regulation of signal transduction by p53 class mediator / ubiquitin ligase inhibitor activity / nuclear-transcribed mRNA catabolic process, nonsense-mediated decay / pigmentation / protein kinase A binding / negative regulation of ubiquitin protein ligase activity / Ribosomal scanning and start codon recognition / ion channel inhibitor activity / Translation initiation complex formation / phagocytic cup / positive regulation of mitochondrial depolarization / negative regulation of Wnt signaling pathway / positive regulation of T cell receptor signaling pathway / positive regulation of activated T cell proliferation / fibroblast growth factor binding / regulation of cell division / ribosomal subunit export from nucleus / SARS-CoV-1 modulates host translation machinery / Protein hydroxylation / iron-sulfur cluster binding / TOR signaling / protein deubiquitination / BH3 domain binding / mTORC1-mediated signalling / endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator / Peptide chain elongation / Selenocysteine synthesis / monocyte chemotaxis / cysteine-type endopeptidase activator activity involved in apoptotic process / Formation of a pool of free 40S subunits / ribosomal small subunit export from nucleus / ribosomal small subunit binding / positive regulation of cyclic-nucleotide phosphodiesterase activity / Eukaryotic Translation Termination / Response of EIF2AK4 (GCN2) to amino acid deficiency / translation regulator activity / SRP-dependent cotranslational protein targeting to membrane / Viral mRNA Translation / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / GTP hydrolysis and joining of the 60S ribosomal subunit / negative regulation of proteasomal ubiquitin-dependent protein catabolic process / negative regulation of respiratory burst involved in inflammatory response / negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / L13a-mediated translational silencing of Ceruloplasmin expression
Similarity search - Function
Eukaryotic translation initiation factor 3 subunit J / Eukaryotic translation initiation factor 3-like domain superfamily / Translation initiation factor eIF3 subunit / Eukaryotic translation initiation factor 3 subunit D / Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) / Eukaryotic translation initiation factor 3 subunit H / eIF3h, C-terminal / C-terminal region of eIF3h / Eukaryotic translation initiation factor 3 subunit F / Translation initiation factor 3 complex subunit L ...Eukaryotic translation initiation factor 3 subunit J / Eukaryotic translation initiation factor 3-like domain superfamily / Translation initiation factor eIF3 subunit / Eukaryotic translation initiation factor 3 subunit D / Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) / Eukaryotic translation initiation factor 3 subunit H / eIF3h, C-terminal / C-terminal region of eIF3h / Eukaryotic translation initiation factor 3 subunit F / Translation initiation factor 3 complex subunit L / RNA polymerase I-associated factor PAF67 / Eukaryotic translation initiation factor 3 subunit M / eIF3 subunit M, C-terminal helix domain / eIF3 subunit M, C-terminal helix / Eukaryotic translation initiation factor 3 subunit E, C-terminal / Eukaryotic translation initiation factor 3 subunit E / Eukaryotic translation initiation factor 3 subunit E, N-terminal / eIF3 subunit 6 N terminal domain / eIF3 subunit 6 N terminal domain / Eukaryotic translation initiation factor 3 subunit K / Translation initiation factor 3, subunit 12, N-terminal, eukaryotic / Eukaryotic translation initiation factor 3 subunit I / Eukaryotic translation initiation factor SUI1 / RLI, domain 1 / Eukaryotic translation initiation factor 3 subunit B / eIF3B, RNA recognition motif / RLI1 / RNase L inhibitor RLI-like, possible metal-binding domain / Possible Fer4-like domain in RNase L inhibitor, RLI / SUI1 domain superfamily / Eukaryotic translation initiation factor 3 subunit M eIF3m/COP9 signalosome complex subunit 7 COPS7 / Translation initiation factor SUI1 / Translation initiation factor SUI1 family profile. / Eukaryotic translation initiation factor 3 subunit C, N-terminal domain / Eukaryotic translation initiation factor 3 subunit C / Eukaryotic translation initiation factor 3 subunit 8 N-terminus / Translation initiation factor, beta propellor-like domain / Eukaryotic translation initiation factor 3 subunit A / SUI1 domain / Eukaryotic translation initiation factor eIF2A / 4Fe-4S binding domain / Ubiquitin-like protein FUBI / 40S ribosomal protein SA / 40S ribosomal protein SA, C-terminal domain / Anaphase-promoting complex subunit 4, WD40 domain / 40S ribosomal protein SA C-terminus / CSN8/PSMD8/EIF3K / CSN8/PSMD8/EIF3K family / Anaphase-promoting complex subunit 4 WD40 domain / Rpn11/EIF3F, C-terminal / Maintenance of mitochondrial structure and function / motif in proteasome subunits, Int-6, Nip-1 and TRIP-15 / PCI domain / Proteasome component (PCI) domain / PCI domain profile. / JAB1/Mov34/MPN/PAD-1 ubiquitin protease / : / Ribosomal protein L41 / Ribosomal protein L41 / Ribosomal protein S12e / : / Small (40S) ribosomal subunit Asc1/RACK1 / Ribosomal protein S21e, conserved site / Ribosomal protein S26e / Ribosomal protein S26e superfamily / Ribosomal protein S19e, conserved site / S27a-like superfamily / Ribosomal protein S26e / Ribosomal protein S10, eukaryotic/archaeal / Ribosomal protein S25 / Ribosomal protein S26e signature. / Ribosomal protein S17e, conserved site / : / Ribosomal protein S2, eukaryotic / Ribosomal protein S30 / 40S ribosomal protein S29/30S ribosomal protein S14 type Z / Ribosomal protein S27a / Ribosomal protein S27a / Ribosomal protein S21e / Ribosomal protein S21e superfamily / Ribosomal protein S21e / Ribosomal protein S3, eukaryotic/archaeal / Ribosomal protein S8e subdomain, eukaryotes / S25 ribosomal protein / Ribosomal protein S19A/S15e / Ribosomal protein S21e signature. / Ribosomal protein S30 / Ribosomal protein S3Ae, conserved site / Ribosomal protein S12e signature. / Ribosomal protein S17e / Ribosomal protein S17e-like superfamily / Ribosomal protein S27a / Ribosomal protein S2, eukaryotic/archaeal / Ribosomal protein S19e / Ribosomal_S19e / Ribosomal protein S5, eukaryotic/archaeal / Ribosomal protein S8e, conserved site / 40S ribosomal protein S11, N-terminal / 40S ribosomal protein S1/3, eukaryotes / Ribosomal protein S6, eukaryotic
Similarity search - Domain/homology
40S ribosomal protein S14 / Eukaryotic translation initiation factor 3 subunit C / 40S ribosomal protein S24 / Eukaryotic translation initiation factor 3 subunit F / Eukaryotic translation initiation factor 3 subunit D / Eukaryotic translation initiation factor 3 subunit H / Eukaryotic translation initiation factor 3 subunit J / Small ribosomal subunit protein eS17 / Small ribosomal subunit protein uS2 / Small ribosomal subunit protein uS5 ...40S ribosomal protein S14 / Eukaryotic translation initiation factor 3 subunit C / 40S ribosomal protein S24 / Eukaryotic translation initiation factor 3 subunit F / Eukaryotic translation initiation factor 3 subunit D / Eukaryotic translation initiation factor 3 subunit H / Eukaryotic translation initiation factor 3 subunit J / Small ribosomal subunit protein eS17 / Small ribosomal subunit protein uS2 / Small ribosomal subunit protein uS5 / Small ribosomal subunit protein uS3 / Small ribosomal subunit protein eS12 / Small ribosomal subunit protein eS19 / Eukaryotic translation initiation factor 1 / Small ribosomal subunit protein eS27 / Small ribosomal subunit protein uS4 / Small ribosomal subunit protein uS7 / Small ribosomal subunit protein eS10 / Eukaryotic translation initiation factor 3 subunit B / Eukaryotic translation initiation factor 3 subunit E / Small ribosomal subunit protein uS10 / ATP-binding cassette sub-family E member 1 / Small ribosomal subunit protein eS1 / Small ribosomal subunit protein eS7 / Small ribosomal subunit protein eS8 / Small ribosomal subunit protein uS8 / Small ribosomal subunit protein uS9 / Small ribosomal subunit protein uS12 / Small ribosomal subunit protein uS13 / Small ribosomal subunit protein uS14 / Small ribosomal subunit protein uS15 / Small ribosomal subunit protein uS17 / Small ribosomal subunit protein eS4, X isoform / Small ribosomal subunit protein eS6 / Small ribosomal subunit protein uS19 / Small ribosomal subunit protein eS25 / Small ribosomal subunit protein eS26 / Small ribosomal subunit protein eS28 / Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein / Small ribosomal subunit protein eS32 / Ubiquitin-ribosomal protein eS31 fusion protein / Small ribosomal subunit protein eS21 / Small ribosomal subunit protein RACK1 / Eukaryotic translation initiation factor 3 subunit I / Eukaryotic translation initiation factor 3 subunit A / Eukaryotic translation initiation factor 3 subunit M / Eukaryotic translation initiation factor 3 subunit K / Eukaryotic translation initiation factor 3 subunit L
Similarity search - Component
Biological speciesHomo sapiens (human) / Human (human)
Methodsingle particle reconstruction / cryo EM / Resolution: 3.8 Å
AuthorsKratzat H / Mackens-Kiani T / Ameismeier A / Cheng J / Berninghausen O / Becker T / Beckmann R
Funding support Germany, France, 2 items
OrganizationGrant numberCountry
German Research Foundation (DFG) Germany
Centre National de la Recherche Scientifique (CNRS) France
CitationJournal: EMBO J / Year: 2021
Title: A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes.
Authors: Hanna Kratzat / Timur Mackens-Kiani / Michael Ameismeier / Mia Potocnjak / Jingdong Cheng / Estelle Dacheux / Abdelkader Namane / Otto Berninghausen / Franz Herzog / Micheline Fromont-Racine ...Authors: Hanna Kratzat / Timur Mackens-Kiani / Michael Ameismeier / Mia Potocnjak / Jingdong Cheng / Estelle Dacheux / Abdelkader Namane / Otto Berninghausen / Franz Herzog / Micheline Fromont-Racine / Thomas Becker / Roland Beckmann /
Abstract: In eukaryotic translation, termination and ribosome recycling phases are linked to subsequent initiation of a new round of translation by persistence of several factors at ribosomal sub-complexes. ...In eukaryotic translation, termination and ribosome recycling phases are linked to subsequent initiation of a new round of translation by persistence of several factors at ribosomal sub-complexes. These comprise/include the large eIF3 complex, eIF3j (Hcr1 in yeast) and the ATP-binding cassette protein ABCE1 (Rli1 in yeast). The ATPase is mainly active as a recycling factor, but it can remain bound to the dissociated 40S subunit until formation of the next 43S pre-initiation complexes. However, its functional role and native architectural context remains largely enigmatic. Here, we present an architectural inventory of native yeast and human ABCE1-containing pre-initiation complexes by cryo-EM. We found that ABCE1 was mostly associated with early 43S, but also with later 48S phases of initiation. It adopted a novel hybrid conformation of its nucleotide-binding domains, while interacting with the N-terminus of eIF3j. Further, eIF3j occupied the mRNA entry channel via its ultimate C-terminus providing a structural explanation for its antagonistic role with respect to mRNA binding. Overall, the native human samples provide a near-complete molecular picture of the architecture and sophisticated interaction network of the 43S-bound eIF3 complex and the eIF2 ternary complex containing the initiator tRNA.
History
DepositionJul 24, 2020-
Header (metadata) releaseOct 7, 2020-
Map releaseOct 7, 2020-
UpdateJan 13, 2021-
Current statusJan 13, 2021Processing site: PDBe / Status: Released

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Structure visualization

Movie
  • Surface view with section colored by density value
  • Surface level: 0.015
  • Imaged by UCSF Chimera
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  • Surface view colored by height
  • Surface level: 0.015
  • Imaged by UCSF Chimera
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  • Surface view with fitted model
  • Atomic models: PDB-6zvj
  • Surface level: 0.015
  • Imaged by UCSF Chimera
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Movie viewer
Structure viewerEM map:
SurfViewMolmilJmol/JSmol
Supplemental images

emd_11458.png

Downloads & links

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Map

FileDownload / File: emd_11458.map.gz / Format: CCP4 / Size: 244.1 MB / Type: IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES)
Voxel sizeX=Y=Z: 1.059 Å
Density
Contour LevelBy AUTHOR: 0.015 / Movie #1: 0.015
Minimum - Maximum-0.03345038 - 0.086971
Average (Standard dev.)-8.5757565e-06 (±0.004475016)
SymmetrySpace group: 1
Details

EMDB XML:

Map geometry
Axis orderXYZ
Origin000
Dimensions400400400
Spacing400400400
CellA=B=C: 423.6 Å
α=β=γ: 90.0 °

CCP4 map header:

modeImage stored as Reals
Å/pix. X/Y/Z1.0591.0591.059
M x/y/z400400400
origin x/y/z0.0000.0000.000
length x/y/z423.600423.600423.600
α/β/γ90.00090.00090.000
start NX/NY/NZ000
NX/NY/NZ162182277
MAP C/R/S123
start NC/NR/NS000
NC/NR/NS400400400
D min/max/mean-0.0330.087-0.000

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Supplemental data

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Additional map: post processed and masked map

Fileemd_11458_additional_1.map
Annotationpost processed and masked map
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AxesZYX

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Additional map: local resolution filtered map

Fileemd_11458_additional_2.map
Annotationlocal resolution filtered map
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AxesZYX

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Additional map: multi body refinement body 1

Fileemd_11458_additional_3.map
Annotationmulti body refinement body 1
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Additional map: multi body refinement body 2

Fileemd_11458_additional_4.map
Annotationmulti body refinement body 2
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Additional map: multi body refinement body 3

Fileemd_11458_additional_5.map
Annotationmulti body refinement body 3
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Additional map: multi body refinement if eIF3 core body 1

Fileemd_11458_additional_6.map
Annotationmulti body refinement if eIF3 core body 1
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Additional map: multi body refinement if eIF3 core body 2

Fileemd_11458_additional_7.map
Annotationmulti body refinement if eIF3 core body 2
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Sample components

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Entire : ABCE1-bound 43S initiation complex

EntireName: ABCE1-bound 43S initiation complex
Components
  • Complex: ABCE1-bound 43S initiation complex
    • Protein or peptide: 40S ribosomal protein SA
    • Protein or peptide: 40S ribosomal protein S3a
    • Protein or peptide: 40S ribosomal protein S2
    • Protein or peptide: 40S ribosomal protein S26
    • Protein or peptide: 40S ribosomal protein S4, X isoformRibosome
    • Protein or peptide: 60S ribosomal protein L41
    • Protein or peptide: 40S ribosomal protein S6
    • Protein or peptide: 40S ribosomal protein S7
    • Protein or peptide: 40S ribosomal protein S8
    • Protein or peptide: 40S ribosomal protein S9
    • Protein or peptide: 40S ribosomal protein S11
    • Protein or peptide: 40S ribosomal protein S13
    • Protein or peptide: 40S ribosomal protein S14
    • Protein or peptide: 40S ribosomal protein S21
    • Protein or peptide: 40S ribosomal protein S15a
    • Protein or peptide: 40S ribosomal protein S23
    • Protein or peptide: 40S ribosomal protein S24
    • Protein or peptide: 40S ribosomal protein S27
    • Protein or peptide: 40S ribosomal protein S30
    • RNA: 18S ribosomal RNA
    • Protein or peptide: 40S ribosomal protein S17
    • Protein or peptide: 40S ribosomal protein S16
    • Protein or peptide: 40S ribosomal protein S3
    • Protein or peptide: 40S ribosomal protein S5
    • Protein or peptide: 40S ribosomal protein S10
    • Protein or peptide: 40S ribosomal protein S12
    • Protein or peptide: 40S ribosomal protein S15
    • Protein or peptide: 40S ribosomal protein S18
    • Protein or peptide: 40S ribosomal protein S19
    • Protein or peptide: 40S ribosomal protein S20
    • Protein or peptide: 40S ribosomal protein S25
    • Protein or peptide: 40S ribosomal protein S28
    • Protein or peptide: 40S ribosomal protein S29
    • Protein or peptide: Ubiquitin-40S ribosomal protein S27a
    • Protein or peptide: Receptor of activated protein C kinase 1
    • Protein or peptide: Eukaryotic translation initiation factor 3 subunit IEukaryotic initiation factor 3
    • Protein or peptide: Eukaryotic translation initiation factor 3 subunit BEukaryotic initiation factor 3
    • Protein or peptide: Eukaryotic translation initiation factor 3 subunit AEukaryotic initiation factor 3
    • Protein or peptide: Eukaryotic translation initiation factor 3 subunit CEukaryotic initiation factor 3
    • Protein or peptide: Eukaryotic translation initiation factor 3 subunit EEukaryotic initiation factor 3
    • Protein or peptide: Eukaryotic translation initiation factor 3 subunit FEukaryotic initiation factor 3
    • Protein or peptide: Eukaryotic translation initiation factor 3 subunit HEukaryotic initiation factor 3
    • Protein or peptide: Eukaryotic translation initiation factor 3 subunit KEukaryotic initiation factor 3
    • Protein or peptide: Eukaryotic translation initiation factor 3 subunit LEukaryotic initiation factor 3
    • Protein or peptide: Eukaryotic translation initiation factor 3 subunit MEukaryotic initiation factor 3
    • Protein or peptide: ATP-binding cassette sub-family E member 1
    • Protein or peptide: Eukaryotic translation initiation factor 1
    • Protein or peptide: Eukaryotic translation initiation factor 3 subunit DEukaryotic initiation factor 3
    • Protein or peptide: RNA recognition motif (unknown)
    • Protein or peptide: Eukaryotic translation initiation factor 3 subunit JEukaryotic initiation factor 3
  • Ligand: ZINC ION
  • Ligand: IRON/SULFUR CLUSTERIron–sulfur cluster
  • Ligand: ADENOSINE-5'-DIPHOSPHATE
  • Ligand: MAGNESIUM ION
  • Ligand: ADENOSINE-5'-TRIPHOSPHATE

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Supramolecule #1: ABCE1-bound 43S initiation complex

SupramoleculeName: ABCE1-bound 43S initiation complex / type: complex / ID: 1 / Parent: 0 / Macromolecule list: #1-#50
Source (natural)Organism: Homo sapiens (human)

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Macromolecule #1: 40S ribosomal protein SA

MacromoleculeName: 40S ribosomal protein SA / type: protein_or_peptide / ID: 1 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 24.260758 KDa
SequenceString: SGALDVLQMK EEDVLKFLAA GTHLGGTNLD FQMEQYIYKR KSDGIYIINL KRTWEKLLLA ARAIVAIENP ADVSVISSRN TGQRAVLKF AAATGATPIA GRFTPGTFTN QIQAAFREPR LLVVTDPRAD HQPLTEASYV NLPTIALCNT DSPLRYVDIA I PCNNKGAH ...String:
SGALDVLQMK EEDVLKFLAA GTHLGGTNLD FQMEQYIYKR KSDGIYIINL KRTWEKLLLA ARAIVAIENP ADVSVISSRN TGQRAVLKF AAATGATPIA GRFTPGTFTN QIQAAFREPR LLVVTDPRAD HQPLTEASYV NLPTIALCNT DSPLRYVDIA I PCNNKGAH SVGLMWWMLA REVLRMRGTI SREHPWEVMP DLYFYRDPEE IEKEEQAA

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Macromolecule #2: 40S ribosomal protein S3a

MacromoleculeName: 40S ribosomal protein S3a / type: protein_or_peptide / ID: 2 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 24.560883 KDa
SequenceString: DPFSKKDWYD VKAPAMFNIR NIGKTLVTRT QGTKIASDGL KGRVFEVSLA DLQNDEVAFR KFKLITEDVQ GKNCLTNFHG MDLTRDKMC SMVKKWQTMI EAHVDVKTTD GYLLRLFCVG FTKKRNNQIR KTSYAQHQQV RQIRKKMMEI MTREVQTNDL K EVVNKLIP ...String:
DPFSKKDWYD VKAPAMFNIR NIGKTLVTRT QGTKIASDGL KGRVFEVSLA DLQNDEVAFR KFKLITEDVQ GKNCLTNFHG MDLTRDKMC SMVKKWQTMI EAHVDVKTTD GYLLRLFCVG FTKKRNNQIR KTSYAQHQQV RQIRKKMMEI MTREVQTNDL K EVVNKLIP DSIGKDIEKA CQSIYPLHDV FVRKVKMLKK PKFELGKLME LHG

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Macromolecule #3: 40S ribosomal protein S2

MacromoleculeName: 40S ribosomal protein S2 / type: protein_or_peptide / ID: 3 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 23.861238 KDa
SequenceString: WMPVTKLGRL VKDMKIKSLE EIYLFSLPIK ESEIIDFFLG ASLKDEVLKI MPVQKQTRAG QRTRFKAFVA IGDYNGHVGL GVKCSKEVA TAIRGAIILA KLSIVPVRRG YWGNKIGKPH TVPCKVTGRC GSVLVRLIPA PRGTGIVSAP VPKKLLMMAG I DDCYTSAR ...String:
WMPVTKLGRL VKDMKIKSLE EIYLFSLPIK ESEIIDFFLG ASLKDEVLKI MPVQKQTRAG QRTRFKAFVA IGDYNGHVGL GVKCSKEVA TAIRGAIILA KLSIVPVRRG YWGNKIGKPH TVPCKVTGRC GSVLVRLIPA PRGTGIVSAP VPKKLLMMAG I DDCYTSAR GCTATLGNFA KATFDAISKT YSYLTPDLWK ETVFTKSPYQ EFTDHLVK

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Macromolecule #4: 40S ribosomal protein S26

MacromoleculeName: 40S ribosomal protein S26 / type: protein_or_peptide / ID: 4 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 11.645794 KDa
SequenceString:
TKKRRNNGRA KKGRGHVQPI RCTNCARCVP KDKAIKKFVI RNIVEAAAVR DISEASVFDA YVLPKLYVKL HYCVSCAIHS KVVRNRSRE ARKDRTPPPR FR

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Macromolecule #5: 40S ribosomal protein S4, X isoform

MacromoleculeName: 40S ribosomal protein S4, X isoform / type: protein_or_peptide / ID: 5 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 28.892998 KDa
SequenceString: ARGPKKHLKR VAAPKHWMLD KLTGVFAPRP STGPHKLREC LPLIIFLRNR LKYALTGDEV KKICMQRFIK IDGKVRTDIT YPAGFMDVI SIDKTGENFR LIYDTKGRFA VHRITPEEAK YKLCKVRKIF VGTKGIPHLV THDARTIRYP DPLIKVNDTI Q IDLETGKI ...String:
ARGPKKHLKR VAAPKHWMLD KLTGVFAPRP STGPHKLREC LPLIIFLRNR LKYALTGDEV KKICMQRFIK IDGKVRTDIT YPAGFMDVI SIDKTGENFR LIYDTKGRFA VHRITPEEAK YKLCKVRKIF VGTKGIPHLV THDARTIRYP DPLIKVNDTI Q IDLETGKI TDFIKFDTGN LCMVTGGANL GRIGVITNRE RHPGSFDVVH VKDANGNSFA TRLSNIFVIG KGNKPWISLP RG KGIRLTI AEERDKRL

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Macromolecule #6: 60S ribosomal protein L41

MacromoleculeName: 60S ribosomal protein L41 / type: protein_or_peptide / ID: 6 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 3.344271 KDa
SequenceString:
MRAKWRKKRM RRLKRKRRKM RQRS

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Macromolecule #7: 40S ribosomal protein S6

MacromoleculeName: 40S ribosomal protein S6 / type: protein_or_peptide / ID: 7 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 25.612301 KDa
SequenceString: KLNISFPATG CQKLIEVDDE RKLRTFYEKR MATEVAADAL GEEWKGYVVR ISGGNDKQGF PMKQGVLTHG RVRLLLSKGH SCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIVKKGEKD IPGLTDTTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRK P LNKEGKKP ...String:
KLNISFPATG CQKLIEVDDE RKLRTFYEKR MATEVAADAL GEEWKGYVVR ISGGNDKQGF PMKQGVLTHG RVRLLLSKGH SCYRPRRTG ERKRKSVRGC IVDANLSVLN LVIVKKGEKD IPGLTDTTVP RRLGPKRASR IRKLFNLSKE DDVRQYVVRK P LNKEGKKP RTKAPKIQRL VTPRVLQHKR RRIALKKQRT KKNKEEAAEY AKLLAKRMKE AKEK

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Macromolecule #8: 40S ribosomal protein S7

MacromoleculeName: 40S ribosomal protein S7 / type: protein_or_peptide / ID: 8 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 20.788342 KDa
SequenceString:
IVKPNEFESG ISQALLELEM NSDLKAQLRE LNITAAKEIE VGGGRKAIII FVPVPQLKSF QKIQVRLVRE LEKKFSGKHV VFIAQRRIL PKPTRKSRTK NKQKRPRSRT LTAVHDAILE DLVFPSEIVG KRIRVKLDGS RLIKVHLDKA QQNNVEHKVE T FSGVYKKL TGKDVNFEFP EFQ

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Macromolecule #9: 40S ribosomal protein S8

MacromoleculeName: 40S ribosomal protein S8 / type: protein_or_peptide / ID: 9 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 23.945959 KDa
SequenceString: GISRDNWHKR RKTGGKRKPY HKKRKYELGR PAANTKIGPR RIHTVRVRGG NKKYRALRLD VGNFSWGSEC CTRKTRIIDV VYNASNNEL VRTKTLVKNC IVLIDSTPYR QWYESHYALP LGRKKGAKLT PEEEEILNKK RSKKIQKKYD ERKKNAKISS L LEEQFQQG ...String:
GISRDNWHKR RKTGGKRKPY HKKRKYELGR PAANTKIGPR RIHTVRVRGG NKKYRALRLD VGNFSWGSEC CTRKTRIIDV VYNASNNEL VRTKTLVKNC IVLIDSTPYR QWYESHYALP LGRKKGAKLT PEEEEILNKK RSKKIQKKYD ERKKNAKISS L LEEQFQQG KLLACIASRP GQCGRADGYV LEGKELEFYL RKIKARK

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Macromolecule #10: 40S ribosomal protein S9

MacromoleculeName: 40S ribosomal protein S9 / type: protein_or_peptide / ID: 10 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 21.279271 KDa
SequenceString:
PVARSWVCRK TYVTPRRPFE KSRLDQELKL IGEYGLRNKR EVWRVKFTLA KIRKAARELL TLDEKDPRRL FEGNALLRRL VRIGVLDEG KMKLDYILGL KIEDFLERRL QTQVFKLGLA KSIHHARVLI RQRHIRVRKQ VVNIPSFIVR LDSQKHIDFS L RSPYGGGR PGRVKRKNAK KG

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Macromolecule #11: 40S ribosomal protein S11

MacromoleculeName: 40S ribosomal protein S11 / type: protein_or_peptide / ID: 11 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 16.913004 KDa
SequenceString:
IQTERAYQKQ PTIFQNKKRV LLGETGKEKL PRYYKNIGLG FKTPKEAIEG TYIDKKCPFT GNVSIRGRIL SGVVTKMKMQ RTIVIRRDY LHYIRKYNRF EKRHKNMSVH LSPCFRDVQI GDIVTVGECR PLSKTVRFNV LKVTK

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Macromolecule #12: 40S ribosomal protein S13

MacromoleculeName: 40S ribosomal protein S13 / type: protein_or_peptide / ID: 12 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 17.057113 KDa
SequenceString:
GRMHAPGKGL SQSALPYRRS VPTWLKLTSD DVKEQIYKLA KKGLTPSQIG VILRDSHGVA QVRFVTGNKI LRILKSKGLA PDLPEDLYH LIKKAVAVRK HLERNRKDKD AKFRLILIES RIHRLARYYK TKRVLPPNWK YESSTASALV

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Macromolecule #13: 40S ribosomal protein S14

MacromoleculeName: 40S ribosomal protein S14 / type: protein_or_peptide / ID: 13 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 13.463481 KDa
SequenceString:
NVFGVCHIFA SFNDTFVHVT DLSGKETICR VTGGMKVKAD RDESSPYAAM LAAQDVAQRC KELGITALHI KLRATGGNRT KTPGPGAQS ALRALARSGM KIGRIEDVTP IPSDSTRRKG GRRGRR

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Macromolecule #14: 40S ribosomal protein S21

MacromoleculeName: 40S ribosomal protein S21 / type: protein_or_peptide / ID: 14 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 8.977214 KDa
SequenceString:
MQNDAGEFVD LYVPRKCSAS NRIIGAKDHA SIQMNVAEVD KVTGRFNGQF KTYAICGAIR RMGESDDSIL RLAKADGIVS KN

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Macromolecule #15: 40S ribosomal protein S15a

MacromoleculeName: 40S ribosomal protein S15a / type: protein_or_peptide / ID: 15 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 14.734357 KDa
SequenceString:
VRMNVLADAL KSINNAEKRG KRQVLIRPCS KVIVRFLTVM MKHGYIGEFE IIDDHRAGKI VVNLTGRLNK CGVISPRFDV QLKDLEKWQ NNLLPSRQFG FIVLTTSAGI MDHEEARRKH TGGKILGFFF

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Macromolecule #16: 40S ribosomal protein S23

MacromoleculeName: 40S ribosomal protein S23 / type: protein_or_peptide / ID: 16 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 15.372082 KDa
SequenceString:
GKCRGLRTAR KLRSHRRDQK WHDKQYKKAH LGTALKANPF GGASHAKGIV LEKVGVEAKQ PNSAIRKCVR VQLIKNGKKI TAFVPNDGC LNFIEENDEV LVAGFGRKGH AVGDIPGVRF KVVKVANVSL LALYKGKKER

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Macromolecule #17: 40S ribosomal protein S24

MacromoleculeName: 40S ribosomal protein S24 / type: protein_or_peptide / ID: 17 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 14.259944 KDa
SequenceString:
VTIRTRKFMT NRLLQRKQMV IDVLHPGKAT VPKTEIREKL AKMYKTTPDV IFVFGFRTHF GGGKTTGFGM IYDSLDYAKK NEPKHRLAR HGLYEKKKTS RKQRKERKNR MKKVRGTAKA NVG

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Macromolecule #18: 40S ribosomal protein S27

MacromoleculeName: 40S ribosomal protein S27 / type: protein_or_peptide / ID: 18 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 9.210843 KDa
SequenceString:
PLAKDLLHPS PEEEKRKHKK KRLVQSPNSY FMDVKCPGCY KITTVFSHAQ TVVLCVGCST VLCQPTGGKA RLTEGCSFRR KQ

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Macromolecule #19: 40S ribosomal protein S30

MacromoleculeName: 40S ribosomal protein S30 / type: protein_or_peptide / ID: 19 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 5.069001 KDa
SequenceString:
ARAGKVRGQT PKVAKQEKKK KKTGRAKRRM QYNRRFVNVG PNAN

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Macromolecule #21: 40S ribosomal protein S17

MacromoleculeName: 40S ribosomal protein S17 / type: protein_or_peptide / ID: 21 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 15.036469 KDa
SequenceString:
GRVRTKTVKK AARVIIEKYY TRLGNDFHTN KRVCEEIAII PSKKLRNKIA GYVTHLMKRI QRGPVRGISI KLQEEERERR DNYVPEVSA LDQEIIEVDP DTKEMLKLLD FGSLSNLQVT QPTVGMNFKT P

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Macromolecule #22: 40S ribosomal protein S16

MacromoleculeName: 40S ribosomal protein S16 / type: protein_or_peptide / ID: 22 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 15.637354 KDa
SequenceString:
SVQVFGRKKT ATAVAHCKRG NGLIKVNGRP LEMIEPRTLQ YKLLEPVLLL GKERFAGVDI RVRVKGGGHV AQIYAIRQSI SKALVAYYQ KYVDEASKKE IKDILIQYDR TLLVADPRRC ESKKFGGPGA RARYQKSYR

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Macromolecule #23: 40S ribosomal protein S3

MacromoleculeName: 40S ribosomal protein S3 / type: protein_or_peptide / ID: 23 / Number of copies: 1 / Enantiomer: LEVO / EC number: DNA-(apurinic or apyrimidinic site) lyase
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 24.871156 KDa
SequenceString: QISKKRKFVA DGIFKAELNE FLTRELAEDG YSGVEVRVTP TRTEIIILAT RTQNVLGEKG RRIRELTAVV QKRFGFPEGS VELYAEKVA TRGLCAIAQA ESLRYKLLGG LAVRRACYGV LRFIMESGAK GCEVVVSGKL RGQRAKSMKF VDGLMIHSGD P VNYYVDTA ...String:
QISKKRKFVA DGIFKAELNE FLTRELAEDG YSGVEVRVTP TRTEIIILAT RTQNVLGEKG RRIRELTAVV QKRFGFPEGS VELYAEKVA TRGLCAIAQA ESLRYKLLGG LAVRRACYGV LRFIMESGAK GCEVVVSGKL RGQRAKSMKF VDGLMIHSGD P VNYYVDTA VRHVLLRQGV LGIKVKIMLP WDPTGKIGPK KPLPDHVSIV EPKDEILPTT PISEQK

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Macromolecule #24: 40S ribosomal protein S5

MacromoleculeName: 40S ribosomal protein S5 / type: protein_or_peptide / ID: 24 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 21.327723 KDa
SequenceString:
DIKLFGKWST DDVQINDISL QDYIAVKEKY AKYLPHSAGR YAAKRFRKAQ CPIVERLTNS MMMHGRNNGK KLMTVRIVKH AFEIIHLLT GENPLQVLVN AIINSGPRED STRIGRAGTV RRQAVDVSPL RRVNQAIWLL CTGAREAAFR NIKTIAECLA D ELINAAKG SSNSYAIKKK DELERVAKSN R

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Macromolecule #25: 40S ribosomal protein S10

MacromoleculeName: 40S ribosomal protein S10 / type: protein_or_peptide / ID: 25 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 11.372488 KDa
SequenceString:
MLMPKKNRIA IYELLFKEGV MVAKKDVHMP KHPELADKNV PNLHVMKAMQ SLKSRGYVKE QFAWRHFYWY LTNEGIQYLR DYLHLPPEI VPATLR

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Macromolecule #26: 40S ribosomal protein S12

MacromoleculeName: 40S ribosomal protein S12 / type: protein_or_peptide / ID: 26 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 12.945101 KDa
SequenceString:
VNTALQEVLK TALIHDGLAR GIREAAKALD KRQAHLCVLA SNCDEPMYVK LVEALCAEHQ INLIKVDDNK KLGEWVGLCK IDREGKPRK VVGCSCVVVK DYGKESQAKD VIEEYFK

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Macromolecule #27: 40S ribosomal protein S15

MacromoleculeName: 40S ribosomal protein S15 / type: protein_or_peptide / ID: 27 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 14.01054 KDa
SequenceString:
FTYRGVDLDQ LLDMSYEQLM QLYSARQRRR LNRGLRRKQH SLLKRLRKAK KEAPPMEKPE VVKTHLRDMI ILPEMVGSMV GVYNGKTFN QVEIKPEMIG HYLGEFSITY KPVKHGRPGI

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Macromolecule #28: 40S ribosomal protein S18

MacromoleculeName: 40S ribosomal protein S18 / type: protein_or_peptide / ID: 28 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 16.496223 KDa
SequenceString:
LVIPEKFQHI LRVLNTNIDG RRKIAFAITA IKGVGRRYAH VVLRKADIDL TKRAGELTED EVERVITIMQ NPRQYKIPDW FLNRQKDVK DGKYSQVLAN GLDNKLREDL ERLKKIRAHR GLRHFWGLRV RGQHTKTTGR R

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Macromolecule #29: 40S ribosomal protein S19

MacromoleculeName: 40S ribosomal protein S19 / type: protein_or_peptide / ID: 29 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 15.563858 KDa
SequenceString:
PGVTVKDVNQ QEFVRALAAF LKKSGKLKVP EWVDTVKLAK HKELAPYDEN WFYTRAASTA RHLYLRGGAG VGSMTKIYGG RQRNGVMPS HFSRGSKSVA RRVLQALEGL KMVEKDQDGG RKLTPQGQRD LDRIAGQVAA AN

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Macromolecule #30: 40S ribosomal protein S20

MacromoleculeName: 40S ribosomal protein S20 / type: protein_or_peptide / ID: 30 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 11.186265 KDa
SequenceString:
RIRITLTSRN VKSLEKVCAD LIRGAKEKNL KVKGPVRMPT KTLRITTRKT PCGEGSKTWD RFQMRIHKRL IDLHSPSEIV KQITSISIE PGVEVEVTI

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Macromolecule #31: 40S ribosomal protein S25

MacromoleculeName: 40S ribosomal protein S25 / type: protein_or_peptide / ID: 31 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 7.938426 KDa
SequenceString:
LNNLVLFDKA TYDKLCKEVP NYKLITPAVV SERLKIRGSL ARAALQELLS KGLIKLVSKH RAQVIYTRNT

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Macromolecule #32: 40S ribosomal protein S28

MacromoleculeName: 40S ribosomal protein S28 / type: protein_or_peptide / ID: 32 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 6.87894 KDa
SequenceString:
PIKLARVTKV LGRTGSQGQC TQVRVEFMDD TSRSIIRNVK GPVREGDVLT LLESEREARR L

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Macromolecule #33: 40S ribosomal protein S29

MacromoleculeName: 40S ribosomal protein S29 / type: protein_or_peptide / ID: 33 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 6.444537 KDa
SequenceString:
GHQQLYWSHP RKFGQGSRSC RVCSNRHGLI RKYGLNMCRQ CFRQYAKDIG FIKL

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Macromolecule #34: Ubiquitin-40S ribosomal protein S27a

MacromoleculeName: Ubiquitin-40S ribosomal protein S27a / type: protein_or_peptide / ID: 34 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 7.257627 KDa
SequenceString:
PKKNKHKRKK VKLAVLKYYK VDENGKISRL RRECPSDECG AGVFMASHFD RHYCGKCCLT YC

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Macromolecule #35: Receptor of activated protein C kinase 1

MacromoleculeName: Receptor of activated protein C kinase 1 / type: protein_or_peptide / ID: 35 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 34.224641 KDa
SequenceString: QMTLRGTLKG HNGWVTQIAT TPQFPDMILS ASRDKTIIMW KLTRDETNYG IPQRALRGHS HFVSDVVISS DGQFALSGSW DGTLRLWDL TTGTTTRRFV GHTKDVLSVA FSSDNRQIVS GSRDKTIKLW NTLGVCKYTV QDESHSEWVS CVRFSPNSSN P IIVSCGWD ...String:
QMTLRGTLKG HNGWVTQIAT TPQFPDMILS ASRDKTIIMW KLTRDETNYG IPQRALRGHS HFVSDVVISS DGQFALSGSW DGTLRLWDL TTGTTTRRFV GHTKDVLSVA FSSDNRQIVS GSRDKTIKLW NTLGVCKYTV QDESHSEWVS CVRFSPNSSN P IIVSCGWD KLVKVWNLAN CKLKTNHIGH TGYLNTVTVS PDGSLCASGG KDGQAMLWDL NEGKHLYTLD GGDIINALCF SP NRYWLCA ATGPSIKIWD LEGKIIVDEL KQEVISTSSK AEPPQCTSLA WSADGQTLFA GYTDNLVRVW QV

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Macromolecule #36: Eukaryotic translation initiation factor 3 subunit I

MacromoleculeName: Eukaryotic translation initiation factor 3 subunit I / type: protein_or_peptide / ID: 36 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 35.352535 KDa
SequenceString: MKPILLQGHE RSITQIKYNR EGDLLFTVAK DPIVNVWYSV NGERLGTYMG HTGAVWCVDA DWDTKHVLTG SADNSCRLWD CETGKQLAL LKTNSAVRTC GFDFGGNIIM FSTDKQMGYQ CFVSFFDLRD PSQIDNNEPY MKIPCNDSKI TSAVWGPLGE C IIAGHESG ...String:
MKPILLQGHE RSITQIKYNR EGDLLFTVAK DPIVNVWYSV NGERLGTYMG HTGAVWCVDA DWDTKHVLTG SADNSCRLWD CETGKQLAL LKTNSAVRTC GFDFGGNIIM FSTDKQMGYQ CFVSFFDLRD PSQIDNNEPY MKIPCNDSKI TSAVWGPLGE C IIAGHESG ELNQYSAKSG EVLVNVKEHS RQINDIQLSR DMTMFVTASK DNTAKLFDST TLEHQKTFRT ERPVNSAALS PN YDHVVLG GGQEAMDVTT TSTRIGKFEA RFFHLAFEEE FGRVKGHFGP INSVAFHPDG KSYSSGGEDG YVRIHYFDP

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Macromolecule #37: Eukaryotic translation initiation factor 3 subunit B

MacromoleculeName: Eukaryotic translation initiation factor 3 subunit B / type: protein_or_peptide / ID: 37 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 65.901969 KDa
SequenceString: ADGIDSVIVV DNVPQVGPDR LEKLKNVIHK IFSKFGKITN DFYPEEDGKT KGYIFLEYAS PAHAVDAVKN ADGYKLDKQH TFRVNLFTD FDKYMTISDE WDIPEKQPFK DLGNLRYWLE EAECRDQYSV IFESGDRTSI FWNDVKDPVS IEERARWTET Y VRWSPKGT ...String:
ADGIDSVIVV DNVPQVGPDR LEKLKNVIHK IFSKFGKITN DFYPEEDGKT KGYIFLEYAS PAHAVDAVKN ADGYKLDKQH TFRVNLFTD FDKYMTISDE WDIPEKQPFK DLGNLRYWLE EAECRDQYSV IFESGDRTSI FWNDVKDPVS IEERARWTET Y VRWSPKGT YLATFHQRGI ALWGGEKFKQ IQRFSHQGVQ LIDFSPCERY LVTFSPLMDT QDDPQAIIIW DILTGHKKRG FH CESSAHW PIFKWSHDGK FFARMTLDTL SIYETPSMGL LDKKSLKISG IKDFSWSPGG NIIAFWVPED KDIPARVTLM QLP TRQEIR VRNLFNVVDC KLHWQKNGDY LCVKVDRTPK GTQGVVTNFE IFRMREKQVP VDVVEMKETI IAFAWEPNGS KFAV LHGEA PRISVSFYHV KNNGKIELIK MFDKQQANTI FWSPQGQFVV LAGLRSMNGA LAFVDTSDCT VMNIAEHYMA SDVEW DPTG RYVVTSVSWW SHKVDNAYWL WTFQGRLLQK NNKDRFCQLL WRPRPPTLLS QEQIKQIKKD LKKYSKIFEQ KDRLSQ SKA SKE

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Macromolecule #38: Eukaryotic translation initiation factor 3 subunit A

MacromoleculeName: Eukaryotic translation initiation factor 3 subunit A / type: protein_or_peptide / ID: 38 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 85.564188 KDa
SequenceString: YFQRPENALK RANEFLEVGK KQPALDVLYD VMKSKKHRTW QKIHEPIMLK YLELCVDLRK SHLAKEGLYQ YKNICQQVNI KSLEDVVRA YLKMAEEKTE AAKEESQQMV LDIEDLDNIQ TPESVLLSAV SGEDTQDRTD RLLLTPWVKF LWESYRQCLD L LRNNSRVE ...String:
YFQRPENALK RANEFLEVGK KQPALDVLYD VMKSKKHRTW QKIHEPIMLK YLELCVDLRK SHLAKEGLYQ YKNICQQVNI KSLEDVVRA YLKMAEEKTE AAKEESQQMV LDIEDLDNIQ TPESVLLSAV SGEDTQDRTD RLLLTPWVKF LWESYRQCLD L LRNNSRVE RLYHDIAQQA FKFCLQYTRK AEFRKLCDNL RMHLSQIQRH HNQSTAINLN NPESQSMHLE TRLVQLDSAI SM ELWQEAF KAVEDIHGLF SLSKKPPKPQ LMANYYNKVS TVFWKSGNAL FHASTLHRLY HLSREMRKNL TQDEMQRMST RVL LATLSI PITPERTDIA RLLDMDGIIV EKQRRLATLL GLQAPPTRIG LINDMVRFNV LQYVVPEVKD LYNWLEVEFN PLKL CERVT KVLNWVREQP EKEPELQQYV PQLQNNTILR LLQQVSQIYQ SIEFSRLTSL VPFVDAFQLE RAIVDAARHC DLQVR IDHT SRTLSFGSDL NYATREDAPI GPHLQSMPSE QIRNQLTAMS SVLAKALEVI KPAHILQEKE EQHQLAVTAY LKNSRK EHQ RILARRQTIE ERKERLESLN IQREKEELEQ REAELQKVRK AEEERLRQEA KEREKERILQ EHEQIKKKTV RERLEQI KK TELGAKAFKD IDIEDLEELD PDFIMAKQVE QLEKEKKELQ ERLKNQEKKI DYFERAKRLE EIPLIKSAYE EQRIKDMD L W

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Macromolecule #39: Eukaryotic translation initiation factor 3 subunit C

MacromoleculeName: Eukaryotic translation initiation factor 3 subunit C / type: protein_or_peptide / ID: 39 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 86.19757 KDa
SequenceString: MSRFFTTGSD SESESSLSGE ELVTKPVGGN YGKQPLLLSE DEEDTKRVVR SAKDKRFEEL TNLIRTIRNA MKIRDVTKCL EEFELLGKA YGKAKSIVDK EGVPRFYIRI LADLEDYLNE LWEDKEGKKK MNKNNAKALS TLRQKIRKYN KGTEITHAVV I KKLNEILQ ...String:
MSRFFTTGSD SESESSLSGE ELVTKPVGGN YGKQPLLLSE DEEDTKRVVR SAKDKRFEEL TNLIRTIRNA MKIRDVTKCL EEFELLGKA YGKAKSIVDK EGVPRFYIRI LADLEDYLNE LWEDKEGKKK MNKNNAKALS TLRQKIRKYN KGTEITHAVV I KKLNEILQ ARGKKGTDRA AQIELLQLLV QIAAENNLGE GVIVKIKFNI IASLYDYNPN LATYMKPEMW GKCLDCINEL MD ILFANPN IFVGENILEE SENLHNADQP LRVRGCILTL VERMDEEFTK IMQNTDPHSQ EYVEHLKDEA QVCAIIERVQ RYL EEKGTT EEVCRIYLLR ILHTYYKFDY KAHQRQLTPP EGSSKSEQDQ AENEGEDSAV LMERLCKYIY AKDRTDRIRT CAIL CHIYH HALHSRWYQA RDLMLMSHLQ DNIQHADPPV QILYNRTMVQ LGICAFRQGL TKDAHNALLD IQSSGRAKEL LGQGL LLRS LQERNQEQEK VERRRQVPFH LHINLELLEC VYLVSAMLLE IPYMAAHESD ARRRMISKQF HHQLRVGERQ PLLGPP ESM REHVVAASKA MKMGDWKTCH SFIINEKMNG KVWDLFPEAD KVRTMLVRKI QEESLRTYLF TYSSVYDSIS METLSDM FE LDLPTVHSII SKMIINEELM ASLDQPTQTV VMHRTEPTAQ QNLALQLAEK LGSLVENNER VFDHKQGTYG GYFRDQKD G YRKNEGYMRR GGYRQQQSQT AY

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Macromolecule #40: Eukaryotic translation initiation factor 3 subunit E

MacromoleculeName: Eukaryotic translation initiation factor 3 subunit E / type: protein_or_peptide / ID: 40 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 50.43868 KDa
SequenceString: AEYDLTTRIA HFLDRHLVFP LLEFLSVKEI YNEKELLQGK LDLLSDTNMV DFAMDVYKNL YSDDIPHALR EKRTTVVAQL KQLQAETEP IVKMFEDPET TRQMQSTRDG RMLFDYLADK HGFRQEYLDT LYRYAKFQYE CGNYSGAAEY LYFFRVLVPA T DRNALSSL ...String:
AEYDLTTRIA HFLDRHLVFP LLEFLSVKEI YNEKELLQGK LDLLSDTNMV DFAMDVYKNL YSDDIPHALR EKRTTVVAQL KQLQAETEP IVKMFEDPET TRQMQSTRDG RMLFDYLADK HGFRQEYLDT LYRYAKFQYE CGNYSGAAEY LYFFRVLVPA T DRNALSSL WGKLASEILM QNWDAAMEDL TRLKETIDNN SVSSPLQSLQ QRTWLIHWSL FVFFNHPKGR DNIIDLFLYQ PQ YLNAIQT MCPHILRYLT TAVITNKDVR KRRQVLKDLV KVIQQESYTY KDPITEFVEC LYVNFDFDGA QKKLRECESV LVN DFFLVA CLEDFIENAR LFIFETFCRI HQCISINMLA DKLNMTPEEA ERWIVNLIRN ARLDAKIDSK LGHVVMGNNA VSPY QQVIE KTKSLSFRSQ MLAMNIEKKL NQNS

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Macromolecule #41: Eukaryotic translation initiation factor 3 subunit F

MacromoleculeName: Eukaryotic translation initiation factor 3 subunit F / type: protein_or_peptide / ID: 41 / Number of copies: 1 / Enantiomer: LEVO / EC number: ubiquitinyl hydrolase 1
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 29.836004 KDa
SequenceString: GRVVRLHPVI LASIVDSYER RNEGAARVIG TLLGTVDKHS VEVTNCFSVP HNESEDEVAV DMEFAKNMYE LHKKVSPNEL ILGWYATGH DITEHSVLIH EYYSREAPNP IHLTVDTSLQ NGRMSIKAYV STLMGVPGRT MGVMFTPLTV KYAYYDTERI G VDLIMKTC ...String:
GRVVRLHPVI LASIVDSYER RNEGAARVIG TLLGTVDKHS VEVTNCFSVP HNESEDEVAV DMEFAKNMYE LHKKVSPNEL ILGWYATGH DITEHSVLIH EYYSREAPNP IHLTVDTSLQ NGRMSIKAYV STLMGVPGRT MGVMFTPLTV KYAYYDTERI G VDLIMKTC FSPNRVIGLS SDLQQVGGAS ARIQDALSTV LQYAEDVLSG KVSADNTVGR FLMSLVNQVP KIVPDDFETM LN SNINDLL MVTYLANLTQ SQIALNEKLV NL

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Macromolecule #42: Eukaryotic translation initiation factor 3 subunit H

MacromoleculeName: Eukaryotic translation initiation factor 3 subunit H / type: protein_or_peptide / ID: 42 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 36.960078 KDa
SequenceString: AVKQVQIDGL VVLKIIKHYQ EEGQGTEVVQ GVLLGLVVED RLEITNCFPF PQHTEDDADF DEVQYQMEMM RSLRHVNIDH LHVGWYQST YYGSFVTRAL LDSQFSYQHA IEESVVLIYD PIKTAQGSLS LKAYRLTPKL MEVCKEKDFS PEALKKANIT F EYMFEEVP ...String:
AVKQVQIDGL VVLKIIKHYQ EEGQGTEVVQ GVLLGLVVED RLEITNCFPF PQHTEDDADF DEVQYQMEMM RSLRHVNIDH LHVGWYQST YYGSFVTRAL LDSQFSYQHA IEESVVLIYD PIKTAQGSLS LKAYRLTPKL MEVCKEKDFS PEALKKANIT F EYMFEEVP IVIKNSHLIN VLMWELEKKS AVADKHELLS LASSNHLGKN LQLLMDRVDE MSQDIVKYNT YMRNTSKQQQ QK HQYQQRR QQENMQRQSR GEPPLPEEDL SKLFKPPQPP ARMDSLLIAG QINTYCQNIK EFTAQNLGKL FMAQALQEYN N

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Macromolecule #43: Eukaryotic translation initiation factor 3 subunit K

MacromoleculeName: Eukaryotic translation initiation factor 3 subunit K / type: protein_or_peptide / ID: 43 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 24.952424 KDa
SequenceString: AMFEQMRANV GKLLKGIDRY NPENLATLER YVETQAKENA YDLEANLAVL KLYQFNPAFF QTTVTAQILL KALTNLPHTD FTLCKCMID QAHQEERPIR QILYLGDLLE TCHFQAFWQA LDENMDLLEG ITGFEDSVRK FICHVVGITY QHIDRWLLAE M LGDLSDSQ ...String:
AMFEQMRANV GKLLKGIDRY NPENLATLER YVETQAKENA YDLEANLAVL KLYQFNPAFF QTTVTAQILL KALTNLPHTD FTLCKCMID QAHQEERPIR QILYLGDLLE TCHFQAFWQA LDENMDLLEG ITGFEDSVRK FICHVVGITY QHIDRWLLAE M LGDLSDSQ LKVWMSKYGW SADESGQIFI CSQEESIKPK NIVEKIDFDS VSSIMASSQ

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Macromolecule #44: Eukaryotic translation initiation factor 3 subunit L

MacromoleculeName: Eukaryotic translation initiation factor 3 subunit L / type: protein_or_peptide / ID: 44 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 44.172688 KDa
SequenceString: QWLWDIIDEF IYQFQSFSQY RCKTAKKSEE EIDFLRSNPK IWNVHSVLNV LHSLVDKSNI NRQLEVYTSG GDPESVAGEY GRHSLYKML GYFSLVGLLR LHSLLGDYYQ AIKVLENIEL NKKSMYSRVP ECQVTTYYYV GFAYLMMRRY QDAIRVFANI L LYIQRTKS ...String:
QWLWDIIDEF IYQFQSFSQY RCKTAKKSEE EIDFLRSNPK IWNVHSVLNV LHSLVDKSNI NRQLEVYTSG GDPESVAGEY GRHSLYKML GYFSLVGLLR LHSLLGDYYQ AIKVLENIEL NKKSMYSRVP ECQVTTYYYV GFAYLMMRRY QDAIRVFANI L LYIQRTKS MFQRTTYKYE MINKQNEQMH ALLAIALTMY PMRIDESIHL QLREKYGDKM LRMQKGDPQV YEELFSYSCP KF LSPVVPN YDNVHPNYHK EPFLQQLKVF SDEVQQQAQL STIRSFLKLY TTMPVAKLAG FLDLTEQEFR IQLLVFKHKM KNL VWTSGI SALDGEFQSA SEVDFYIDKD MIHIADTKVA RRYGDFFIRQ IHKFEE

+
Macromolecule #45: Eukaryotic translation initiation factor 3 subunit M

MacromoleculeName: Eukaryotic translation initiation factor 3 subunit M / type: protein_or_peptide / ID: 45 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 41.278391 KDa
SequenceString: EEDQAAELRA YLKSKGAEIS EENSEGGLHV DLAQIIEACD VCLKEDDKDV ESVMNSVVSL LLILEPDKQE ALIESLCEKL VKFREGERP SLRLQLLSNL FHGMDKNTPV RYTVYCSLIK VAASCGAIQY IPTELDQVRK WISDWNLTTE KKHTLLRLLY E ALVDCKKS ...String:
EEDQAAELRA YLKSKGAEIS EENSEGGLHV DLAQIIEACD VCLKEDDKDV ESVMNSVVSL LLILEPDKQE ALIESLCEKL VKFREGERP SLRLQLLSNL FHGMDKNTPV RYTVYCSLIK VAASCGAIQY IPTELDQVRK WISDWNLTTE KKHTLLRLLY E ALVDCKKS DAASKVMVEL LGSYTEDNAS QARVDAHRCI VRALKDPNAF LFDHLLTLKP VKFLEGELIH DLLTIFVSAK LA SYVKFYQ NNKDFIDSLG LLHEQNMAKM RLLTFMGMAV ENKEISFDTM QQELQIGADD VEAFVIDAVR TKMVYCKIDQ TQR KVVVSH STHRTFGKQQ WQQLYDTLNA WKQNLNKVKN SLLSLS

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Macromolecule #46: ATP-binding cassette sub-family E member 1

MacromoleculeName: ATP-binding cassette sub-family E member 1 / type: protein_or_peptide / ID: 46 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 66.972789 KDa
SequenceString: KLTRIAIVNH DKCKPKKCRQ ECKKSCPVVR MGKLCIEVTP QSKIAWISET LCIGCGICIK KCPFGALSIV NLPSNLEKET THRYCANAF KLHRLPIPRP GEVLGLVGTN GIGKSTALKI LAGKQKPNLG KYDDPPDWQE ILTYFRGSEL QNYFTKILED D LKAIIKPQ ...String:
KLTRIAIVNH DKCKPKKCRQ ECKKSCPVVR MGKLCIEVTP QSKIAWISET LCIGCGICIK KCPFGALSIV NLPSNLEKET THRYCANAF KLHRLPIPRP GEVLGLVGTN GIGKSTALKI LAGKQKPNLG KYDDPPDWQE ILTYFRGSEL QNYFTKILED D LKAIIKPQ YVDQIPKAAK GTVGSILDRK DETKTQAIVC QQLDLTHLKE RNVEDLSGGE LQRFACAVVC IQKADIFMFD EP SSYLDVK QRLKAAITIR SLINPDRYII VVEHDLSVLD YLSDFICCLY GVPSAYGVVT MPFSVREGIN IFLDGYVPTE NLR FRDASL VFKVAETANE EEVKKMCMYK YPGMKKKMGE FELAIVAGEF TDSEIMVMLG ENGTGKTTFI RMLAGRLKPD EGGE VPVLN VSYKPQKISP KSTGSVRQLL HEKIRDAYTH PQFVTDVMKP LQIENIIDQE VQTLSGGELQ RVALALCLGK PADVY LIDE PSAYLDSEQR LMAARVVKRF ILHAKKTAFV VEHDFIMATY LADRVIVFDG VPSKNTVANS PQTLLAGMNK FLSQLE ITF RRDPNNYRPR INKLNSIKDV EQKKSGNYFF LD

+
Macromolecule #47: Eukaryotic translation initiation factor 1

MacromoleculeName: Eukaryotic translation initiation factor 1 / type: protein_or_peptide / ID: 47 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 10.388935 KDa
SequenceString:
LPAGTEDYIH IRIQQRNGRK TLTTVQGIAD DYDKKKLVKA FKKKFACNGT VIEHPEYGEV IQLQGDQRKN ICQFLVEIGL AKDDQLKVH GF

+
Macromolecule #48: Eukaryotic translation initiation factor 3 subunit D

MacromoleculeName: Eukaryotic translation initiation factor 3 subunit D / type: protein_or_peptide / ID: 48 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 61.489441 KDa
SequenceString: MAKFMTPVIQ DNPSGWGPCA VPEQFRDMPY QPFSKGDRLG KVADWTGATY QDKRYTNKYS SQFGGGSQYA YFHEEDESSF QLVDTARTQ KTAYQRNRMR FAQRNLRRDK DRRNMLQFNL QILPKSAKQK ERERIRLQKK FQKQFGVRQK WDQKSQKPRD S SVEVRSDW ...String:
MAKFMTPVIQ DNPSGWGPCA VPEQFRDMPY QPFSKGDRLG KVADWTGATY QDKRYTNKYS SQFGGGSQYA YFHEEDESSF QLVDTARTQ KTAYQRNRMR FAQRNLRRDK DRRNMLQFNL QILPKSAKQK ERERIRLQKK FQKQFGVRQK WDQKSQKPRD S SVEVRSDW EVKEEMDFPQ LMKMRYLEVS EPQDIECCGA LEYYDKAFDR ITTRSEKPLR SIKRIFHTVT TTDDPVIRKL AK TQGNVFA TDAILATLMS CTRSVYSWDI VVQRVGSKLF FDKRDNSDFD LLTVSETANE PPQDEGNSFN SPRNLAMEAT YIN HNFSQQ CLRMGKERYN FPNPNPFVED DMDKNEIASV AYRYRRWKLG DDIDLIVRCE HDGVMTGANG EVSFINIKTL NEWD SRHCN GVDWRQKLDS QRGAVIATEL KNNSYKLARW TCCALLAGSE YLKLGYVSRY HVKDSSRHVI LGTQQFKPNE FASQI NLSV ENAWGILRCV IDICMKLEEG KYLILKDPNK QVIRVYSLPD GTF

+
Macromolecule #49: RNA recognition motif (unknown)

MacromoleculeName: RNA recognition motif (unknown) / type: protein_or_peptide / ID: 49 / Number of copies: 1 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 5.562077 KDa
SequenceString:
AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAAAA AAAAAAAA

+
Macromolecule #50: Eukaryotic translation initiation factor 3 subunit J

MacromoleculeName: Eukaryotic translation initiation factor 3 subunit J / type: protein_or_peptide / ID: 50 / Number of copies: 2 / Enantiomer: LEVO
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 29.108453 KDa
SequenceString: MAAAAAAAGD SDSWDADAFS VEDPVRKVGG GGTAGGDRWE GEDEDEDVKD NWDDDDDEKK EEAEVKPEVK ISEKKKIAEK IKEKERQQK KRQEEIKKRL EEPEEPKVLT PEEQLADKLR LKKLQEESDL ELAKETFGVN NAVYGIDAMN PSSRDDFTEF G KLLKDKIT ...String:
MAAAAAAAGD SDSWDADAFS VEDPVRKVGG GGTAGGDRWE GEDEDEDVKD NWDDDDDEKK EEAEVKPEVK ISEKKKIAEK IKEKERQQK KRQEEIKKRL EEPEEPKVLT PEEQLADKLR LKKLQEESDL ELAKETFGVN NAVYGIDAMN PSSRDDFTEF G KLLKDKIT QYEKSLYYAS FLEVLVRDVC ISLEIDDLKK ITNSLTVLCS EKQKQEKQSK AKKKKKGVVP GGGLKATMKD DL ADYGGYD GGYVQDYEDF M

+
Macromolecule #20: 18S ribosomal RNA

MacromoleculeName: 18S ribosomal RNA / type: rna / ID: 20 / Number of copies: 1
Source (natural)Organism: Human (human)
Molecular weightTheoretical: 555.210688 KDa
SequenceString: UACCUGGUUG AUCCUGCCAG UAGCAUAUGC UUGUCUCAAA GAUUAAGCCA UGCAUGUCUA AGUACGCACG GCCGGUACAG UGAAACUGC GAAUGGCUCA UUAAAUCAGU UAUGGUUCCU UUGGUCGCUC GUACUUGGAU AACUGUGGUA AUUCUAGAGC U AAUACAUG ...String:
UACCUGGUUG AUCCUGCCAG UAGCAUAUGC UUGUCUCAAA GAUUAAGCCA UGCAUGUCUA AGUACGCACG GCCGGUACAG UGAAACUGC GAAUGGCUCA UUAAAUCAGU UAUGGUUCCU UUGGUCGCUC GUACUUGGAU AACUGUGGUA AUUCUAGAGC U AAUACAUG CCGACGGGCG CUGACCCCCU UCGCGGGGGG GAUGCGUGCA UUUAUCAGUG GUGACUCUAG AUAACCUCGG GC CGAUCGC ACGCCGCGGC GACGACCCAU UCGAACGUCU GCCCUAUCAA CUUUCGAUGG UAGUCGCCGU GCCUACCAUG GUG ACCACG GGUGACGGGG AAUCAGGGUU CGAUUCCGGA GAGGGAGCCU GAGAAACGGC UACCACAUCC AAGGAAGGCA GCAG GCGCG CAAAUUACCC ACUCCCGACC CGGGGAGGUA GUGACGAAAA AUAACAAUAC AGGACUCUUU CGAGGCCCUG UAAUU GGAA UGAGUCCACU UUAAAUCCUU UAACGAGGAU CCAUUGGAGG GCAAGUCUGG UGCCAGCAGC CGCGGUAAUU CCAGCU CCA AUAGCGUAUA UUAAAGUUGC UGCAGUUAAA AAGCUCGUAG UUGGAUCUUG GGAGCGGGCG GGCGGUCCGC CGCGAGG CG AGCCACCGCC CGUCCCCGCC UCUCGGCCGA AGCGUUUACU UUGAAAAAAU UAGAGUGUUC AAAGCAGGCC GCCUGGAU A CCGCAGCUAG GAAUAAUGGA AUAGGACCGC GGUUCUAUUU UGUUGGUUUU CGGAACUGAG GCCAUGAUUA AGAGGGACG GCCGGGGGCA UUCGUAUUGC GCCGCUAGAG GUGAAAUUCU UGGACCGGCG CAAGACGGAC CAGAGCGAAA GCAUUUGCCA AGAAUGUUU UCAUUAAUCA AGAACGAAAG UCGGAGGUUC GAAGACGAUC AGAUACCGUC GUAGUUCCGA CCAUAAACGA U GCCGACCG GCGAUGCGGC GGCGUUAUUC CCAUGACCCG CCGGGCAGCU UCCGGGAAAC CAAAGUCUUU GGGUUCCGGG GG GAGUAUG GUUGCAAAGC UGAAACUUAA AGGAAUUGAC GGAAGGGCAC CACCAGGAGU GGAGCCUGCG GCUUAAUUUG ACU CAACAC GGGAAACCUC ACCCGGCCCG GACACGGACA GGAUUGACAG AUUGAUAGCU CUUUCUCGAU UCCGUGGGUG GUGG UGCAU GGCCGUUCUU AGUUGGUGGA GCGAUUUGUC UGGUUAAUUC CGAUAACGAA CGAGACUCUG GCAUGCUAAC UAGUU ACGC GACCGGUCGG CGUAACUUCU UAGAGGGACA AGUGGCGUUC AGCCACCCGA GAUUGAGCAA UAACAGGUCU GUGAUG CCC UUAGAUGUCC GGGGCUGCAC GCGCGCUACA CUGACUGGCU CAGCGUGUGC CUACCCUACG CCGGCAGGCG CGGGUAA CC CGUUGAACCC CAUUCGUGAU GGGGAUCGGG GAUUGCAAUU AUUCCCCAUG AACGAGGAAU UCCCAGUAAG UGCGGGUC A UAAGCUUGCG UUGAUUAAGU CCCUGCCCUU UGUACACACC GCCCGUCGCU ACUACCGAUU GGAUGGUUUA GUGAGGCCC UCGGAUCGGC CCCGCCGGGG UGCCCUGGCG GAGCGCUGAG AAGACGGUCG AACUUGACUA UCUAGAGGAA GUAAAAGUCG UAACAAGGU UUCCGUAGGU AAACCUGCGG AAGGAUCAUU A

+
Macromolecule #51: ZINC ION

MacromoleculeName: ZINC ION / type: ligand / ID: 51 / Number of copies: 3 / Formula: ZN
Molecular weightTheoretical: 65.409 Da

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Macromolecule #52: IRON/SULFUR CLUSTER

MacromoleculeName: IRON/SULFUR CLUSTER / type: ligand / ID: 52 / Number of copies: 2 / Formula: SF4
Molecular weightTheoretical: 351.64 Da
Chemical component information

ChemComp-FS1:
IRON/SULFUR CLUSTER / Iron–sulfur cluster

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Macromolecule #53: ADENOSINE-5'-DIPHOSPHATE

MacromoleculeName: ADENOSINE-5'-DIPHOSPHATE / type: ligand / ID: 53 / Number of copies: 1 / Formula: ADP
Molecular weightTheoretical: 427.201 Da
Chemical component information

ChemComp-ADP:
ADENOSINE-5'-DIPHOSPHATE / ADP, energy-carrying molecule*YM / Adenosine diphosphate

+
Macromolecule #54: MAGNESIUM ION

MacromoleculeName: MAGNESIUM ION / type: ligand / ID: 54 / Number of copies: 2 / Formula: MG
Molecular weightTheoretical: 24.305 Da

+
Macromolecule #55: ADENOSINE-5'-TRIPHOSPHATE

MacromoleculeName: ADENOSINE-5'-TRIPHOSPHATE / type: ligand / ID: 55 / Number of copies: 1 / Formula: ATP
Molecular weightTheoretical: 507.181 Da
Chemical component information

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM / Adenosine triphosphate

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Experimental details

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Structure determination

Methodcryo EM
Processingsingle particle reconstruction
Aggregation stateparticle

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Sample preparation

BufferpH: 7.6
VitrificationCryogen name: ETHANE

-
Electron microscopy

MicroscopeFEI TITAN KRIOS
Electron beamAcceleration voltage: 300 kV / Electron source: FIELD EMISSION GUN
Electron opticsIllumination mode: FLOOD BEAM / Imaging mode: BRIGHT FIELDBright-field microscopy
Image recordingFilm or detector model: GATAN K2 QUANTUM (4k x 4k) / Average electron dose: 48.0 e/Å2
Experimental equipment
Model: Titan Krios / Image courtesy: FEI Company

-
Image processing

Initial angle assignmentType: MAXIMUM LIKELIHOOD
Final angle assignmentType: MAXIMUM LIKELIHOOD
Final reconstructionResolution.type: BY AUTHOR / Resolution: 3.8 Å / Resolution method: FSC 0.143 CUT-OFF / Number images used: 5231
FSC plot (resolution estimation)

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