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- SASDG54: Human macrophage mannose receptor 1 protein (Macrophage mannose r... -

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ID or keywords:

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Basic information

Entry
Database: SASBDB / ID: SASDG54
SampleHuman macrophage mannose receptor 1 protein
  • Macrophage mannose receptor 1 (protein), MRC1 or CD206, Mouse myeloma cell line
Function / homology
Function and homology information


cargo receptor activity / Cross-presentation of soluble exogenous antigens (endosomes) / D-mannose binding / cellular response to interleukin-4 / receptor-mediated endocytosis / cellular response to type II interferon / Modulation by Mtb of host immune system / transmembrane signaling receptor activity / virus receptor activity / signaling receptor activity ...cargo receptor activity / Cross-presentation of soluble exogenous antigens (endosomes) / D-mannose binding / cellular response to interleukin-4 / receptor-mediated endocytosis / cellular response to type II interferon / Modulation by Mtb of host immune system / transmembrane signaling receptor activity / virus receptor activity / signaling receptor activity / cellular response to lipopolysaccharide / endosome membrane / cell surface / plasma membrane
Similarity search - Function
Fibronectin type II domain / Fibronectin type II domain superfamily / Fibronectin type II domain / Fibronectin type-II collagen-binding domain signature. / Fibronectin type-II collagen-binding domain profile. / Fibronectin type 2 domain / Ricin-type beta-trefoil lectin domain / C-type lectin, conserved site / C-type lectin domain signature. / Ricin-type beta-trefoil ...Fibronectin type II domain / Fibronectin type II domain superfamily / Fibronectin type II domain / Fibronectin type-II collagen-binding domain signature. / Fibronectin type-II collagen-binding domain profile. / Fibronectin type 2 domain / Ricin-type beta-trefoil lectin domain / C-type lectin, conserved site / C-type lectin domain signature. / Ricin-type beta-trefoil / Lectin domain of ricin B chain profile. / Ricin B, lectin domain / Ricin B-like lectins / Lectin C-type domain / C-type lectin domain profile. / C-type lectin-like / C-type lectin (CTL) or carbohydrate-recognition domain (CRD) / C-type lectin-like/link domain superfamily / C-type lectin fold / Kringle-like fold
Similarity search - Domain/homology
Macrophage mannose receptor 1
Similarity search - Component
Biological speciesMouse myeloma cell line
Contact author
  • Liz Fan (NIH, National Institutes of Health, Bethesda, MD, Bethesda, Maryland, USA)

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Models

Model #3688
Type: other / Comment: Giving silicon model is for MRC1/CD206 monomer. / Chi-square value: 1.94

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Sample

SampleName: Human macrophage mannose receptor 1 protein / Specimen concentration: 0.88-1.76
BufferName: 50mM Hepes, 100mM NaCl, 1mM DTT / pH: 7
Entity #1860Name: MRC1 or CD206 / Type: protein / Description: Macrophage mannose receptor 1 / Formula weight: 157.497 / Num. of mol.: 2 / Source: Mouse myeloma cell line / References: UniProt: P22897
Sequence: LLDTRQFLIY NEDHKRCVDA VSPSAVQTAA CNQDAESQKF RWVSESQIMS VAFKLCLGVP SKTDWVAITL YACDSKSEFQ KWECKNDTLL GIKGEDLFFN YGNRQEKNIM LYKGSGLWSR WKIYGTTDNL CSRGYEAMYT LLGNANGATC AFPFKFENKW YADCTSAGRS ...Sequence:
LLDTRQFLIY NEDHKRCVDA VSPSAVQTAA CNQDAESQKF RWVSESQIMS VAFKLCLGVP SKTDWVAITL YACDSKSEFQ KWECKNDTLL GIKGEDLFFN YGNRQEKNIM LYKGSGLWSR WKIYGTTDNL CSRGYEAMYT LLGNANGATC AFPFKFENKW YADCTSAGRS DGWLWCGTTT DYDTDKLFGY CPLKFEGSES LWNKDPLTSV SYQINSKSAL TWHQARKSCQ QQNAELLSIT EIHEQTYLTG LTSSLTSGLW IGLNSLSFNS GWQWSDRSPF RYLNWLPGSP SAEPGKSCVS LNPGKNAKWE NLECVQKLGY ICKKGNTTLN SFVIPSESDV PTHCPSQWWP YAGHCYKIHR DEKKIQRDAL TTCRKEGGDL ASIHTIEEYD FIISQLGYEP NDELWIGLND IKIQMYFEWS DGTPVTFTKW LRGEPSHENN RQEDCVVMKG KDGYWADRGC EWPLGYICKM KSRSQGPEIV EVEKGCRKGW KKHHFYCYMI GHTLSTFAEA NQTCNNENAY LTTIEDRYEQ AFLTSFVGLR PEKYFWTGLS DIQTKGTFQW TIEEEVRFTH WNSDMPGRKP GCVAMRTGIA GGLWDVLKCD EKAKFVCKHW AEGVTHPPKP TTTPEPKCPE DWGASSRTSL CFKLYAKGKH EKKTWFESRD FCRALGGDLA SINNKEEQQT IWRLITASGS YHKLFWLGLT YGSPSEGFTW SDGSPVSYEN WAYGEPNNYQ NVEYCGELKG DPTMSWNDIN CEHLNNWICQ IQKGQTPKPE PTPAPQDNPP VTEDGWVIYK DYQYYFSKEK ETMDNARAFC KRNFGDLVSI QSESEKKFLW KYVNRNDAQS AYFIGLLISL DKKFAWMDGS KVDYVSWATG EPNFANEDEN CVTMYSNSGF WNDINCGYPN AFICQRHNSS INATTVMPTM PSVPSGCKEG WNFYSNKCFK IFGFMEEERK NWQEARKACI GFGGNLVSIQ NEKEQAFLTY HMKDSTFSAW TGLNDVNSEH TFLWTDGRGV HYTNWGKGYP GGRRSSLSYE DADCVVIIGG ASNEAGKWMD DTCDSKRGYI CQTRSDPSLT NPPATIQTDG FVKYGKSSYS LMRQKFQWHE AETYCKLHNS LIASILDPYS NAFAWLQMET SNERVWIALN SNLTDNQYTW TDKWRVRYTN WAADEPKLKS ACVYLDLDGY WKTAHCNESF YFLCKRSDEI PATEPPQLPG RCPESDHTAW IPFHGHCYYI ESSYTRNWGQ ASLECLRMGS SLVSIESAAE SSFLSYRVEP LKSKTNFWIG LFRNVEGTWL WINNSPVSFV NWNTGDPSGE RNDCVALHAS SGFWSNIHCS SYKGYICKRP KIIDAKPTHE LLTTKADTRK MDPSKPSSNV HHHHHH

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Experimental information

BeamInstrument name: Advanced Photon Source (APS), Argonne National Laboratory 12ID-B SAXS/WAXS
City: Lemont, IL / 国: USA / Type of source: X-ray synchrotronSynchrotron / Wavelength: 0.093 Å / Dist. spec. to detc.: 2 mm
DetectorName: Pilatus 2M
Scan
Title: Human macrophage mannose receptor 1 protein / Measurement date: Apr 15, 2016 / Storage temperature: 4 °C / Cell temperature: 20 °C / Exposure time: 1 sec. / Number of frames: 30 / Unit: 1/A /
MinMax
Q0.0045 1.04
Distance distribution function P(R)
Sofotware P(R): GNOM 5.0 / Number of points: 229 /
MinMax
Q0.007572 0.308
P(R) point1 229
R0 301
Result
Type of curve: extrapolated /
ExperimentalPorod
MW345 kDa345 kDa
Volume-584 nm3

P(R)GuinierGuinier errorP(R) error
Forward scattering, I00.5277 0.53 0.01 -
Radius of gyration, Rg8.23 nm7.89 nm0.8 0.2

MinMax
D-30.1
Guinier point9 63

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