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- SASDB28: Complement factor 1q (C1q) (Complement C1q subcomponent subunit C... -

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Basic information

Entry
Database: SASBDB / ID: SASDB28
SampleComplement factor 1q (C1q)
  • Complement C1q subcomponent subunit C (protein), C1qc, Homo sapiens (plasma purified)
  • Complement C1q subcomponent subunit B (protein), C1qb, Homo sapiens (plasma purified)
  • Complement C1q subcomponent subunit A (protein), C1qa, Homo sapiens
Function / homology
Function and homology information


complement component C1 complex / complement component C1q complex / negative regulation of macrophage differentiation / synapse pruning / negative regulation of granulocyte differentiation / vertebrate eye-specific patterning / complement-mediated synapse pruning / collagen trimer / complement activation / Classical antibody-mediated complement activation ...complement component C1 complex / complement component C1q complex / negative regulation of macrophage differentiation / synapse pruning / negative regulation of granulocyte differentiation / vertebrate eye-specific patterning / complement-mediated synapse pruning / collagen trimer / complement activation / Classical antibody-mediated complement activation / neuron remodeling / Initial triggering of complement / complement activation, classical pathway / Regulation of Complement cascade / astrocyte activation / synapse organization / microglial cell activation / cell-cell signaling / amyloid-beta binding / postsynapse / collagen-containing extracellular matrix / blood microparticle / immune response / innate immune response / synapse / extracellular space / extracellular region
Similarity search - Function
C1q domain / C1q domain / C1q domain profile. / Complement component C1q domain. / Tumour necrosis factor-like domain superfamily / Collagen triple helix repeat / Collagen triple helix repeat (20 copies)
Similarity search - Domain/homology
Complement C1q subcomponent subunit A / Complement C1q subcomponent subunit B / Complement C1q subcomponent subunit C
Similarity search - Component
Biological speciesHomo sapiens (plasma purified)
Homo sapiens (human)
Contact author
  • Rasmus Jensen (Aarhus University, Aarhus, Denmark)

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Structure visualization

Downloads & links

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Models

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Sample

SampleName: Complement factor 1q (C1q) / Specimen concentration: 3.66-3.66 / Entity id: 541 / 542 / 543
BufferName: 50 mM TrisHCl, 145 mM NaCl, 3 mM CaCl2 / pH: 7.4
Entity #541Name: C1qc / Type: protein / Description: Complement C1q subcomponent subunit C / Formula weight: 23.687 / Num. of mol.: 6 / Source: Homo sapiens (plasma purified) / References: UniProt: P02747
Sequence: EDLCRAPDGK KGEAGRPGRR GRPGLKGEQG EPGAPGIRTG IQGLKGDQGE PGPSGNPGKV GYPGPSGPLG ARGIPGIKGT KGSPGNIKDQ PRPAFSAIRR NPPMGGNVVI FDTVITNQEE PYQNHSGRFV CTVPGYYYFT FQVLSQWEIC LSIVSSSRGQ VRRSLGFCDT ...Sequence:
EDLCRAPDGK KGEAGRPGRR GRPGLKGEQG EPGAPGIRTG IQGLKGDQGE PGPSGNPGKV GYPGPSGPLG ARGIPGIKGT KGSPGNIKDQ PRPAFSAIRR NPPMGGNVVI FDTVITNQEE PYQNHSGRFV CTVPGYYYFT FQVLSQWEIC LSIVSSSRGQ VRRSLGFCDT TNKGLFQVVS GGMVLQLQQG DQVWVEKDPK KGHIYQGSEA DSVFSGFLIF PSA
Entity #542Name: C1qb / Type: protein / Description: Complement C1q subcomponent subunit B / Formula weight: 23.742 / Num. of mol.: 6 / Source: Homo sapiens (plasma purified) / References: UniProt: P02746
Sequence: QLSCTGPPAI PGIPGIPGTP GPDGQPGTPG IKGEKGLPGL AGDHGEFGEK GDPGIPGNPG KVGPKGPMGP KGGPGAPGAP GPKGESGDYK ATQKIAFSAT RTINVPLRRD QTIRFDHVIT NMNNNYEPRS GKFTCKVPGL YYFTYHASSR GNLCVNLMRG RERAQKVVTF ...Sequence:
QLSCTGPPAI PGIPGIPGTP GPDGQPGTPG IKGEKGLPGL AGDHGEFGEK GDPGIPGNPG KVGPKGPMGP KGGPGAPGAP GPKGESGDYK ATQKIAFSAT RTINVPLRRD QTIRFDHVIT NMNNNYEPRS GKFTCKVPGL YYFTYHASSR GNLCVNLMRG RERAQKVVTF CDYAYNTFQV TTGGMVLKLE QGENVFLQAT DKNSLLGMEG ANSIFSGFLL FPDMEA
Entity #543Name: C1qa / Type: protein / Description: Complement C1q subcomponent subunit A / Formula weight: 23.687 / Num. of mol.: 6 / Source: Homo sapiens / References: UniProt: P02745
Sequence: EDLCRAPDGK KGEAGRPGRR GRPGLKGEQG EPGAPGIRTG IQGLKGDQGE PGPSGNPGKV GYPGPSGPLG ARGIPGIKGT KGSPGNIKDQ PRPAFSAIRR NPPMGGNVVI FDTVITNQEE PYQNHSGRFV CTVPGYYYFT FQVLSQWEIC LSIVSSSRGQ VRRSLGFCDT ...Sequence:
EDLCRAPDGK KGEAGRPGRR GRPGLKGEQG EPGAPGIRTG IQGLKGDQGE PGPSGNPGKV GYPGPSGPLG ARGIPGIKGT KGSPGNIKDQ PRPAFSAIRR NPPMGGNVVI FDTVITNQEE PYQNHSGRFV CTVPGYYYFT FQVLSQWEIC LSIVSSSRGQ VRRSLGFCDT TNKGLFQVVS GGMVLQLQQG DQVWVEKDPK KGHIYQGSEA DSVFSGFLIF PSA

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Experimental information

BeamInstrument name: ESRF BM29 / City: Grenoble / 国: France / Type of source: X-ray synchrotronSynchrotron / Wavelength: 0.0992 Å
DetectorName: Pilatus 1M
Scan
Title: Complement factor 1q (C1q) / Measurement date: Dec 8, 2014 / Storage temperature: 4 °C / Cell temperature: 4 °C / Exposure time: 2 sec. / Number of frames: 10 / Unit: 1/nm /
MinMax
Q0.0364 4.9745
ResultType of curve: single_conc /
ExperimentalStandard
MW407 kDa407 kDa

GuinierGuinier error
Forward scattering, I0534.52 0.97
Radius of gyration, Rg12.61 nm0.17

MinMax
Guinier point4 15

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