登録情報 | データベース: EMDB / ID: EMD-18304 |
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タイトル | Outer kinetochore Ndc80-Dam1 alpha/beta-tubulin complex |
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マップデータ | 3D flex reconstruction |
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試料 | - 複合体: Outer kinetochore Ndc80-Nuf2 CH domains bound to Dam1 in complex with alpha-beta tubulin
- タンパク質・ペプチド: Tubulin alpha-1A chain
![](img/lk-wikipe.gif) - タンパク質・ペプチド: Tubulin beta chain
- タンパク質・ペプチド: Kinetochore protein NDC80
動原体 - タンパク質・ペプチド: Kinetochore protein NUF2
動原体 - タンパク質・ペプチド: DASH complex subunit DAM1
- リガンド: GUANOSINE-5'-TRIPHOSPHATE
グアノシン三リン酸 - リガンド: MAGNESIUM ION
- リガンド: GUANOSINE-5'-DIPHOSPHATE
- リガンド: TAXOL
パクリタキセル |
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キーワード | Kinetochore (動原体) / microtubule (微小管) / error correction / chromosome segregation / CELL CYCLE (細胞周期) |
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機能・相同性 | 機能・相同性情報
mitotic spindle polar microtubule / Ndc80 complex / DASH complex / protein transport along microtubule to mitotic spindle pole body / mitotic sister chromatid biorientation / kinetochore organization / positive regulation of attachment of spindle microtubules to kinetochore / meiotic chromosome segregation / mitotic spindle pole body / attachment of spindle microtubules to kinetochore ...mitotic spindle polar microtubule / Ndc80 complex / DASH complex / protein transport along microtubule to mitotic spindle pole body / mitotic sister chromatid biorientation / kinetochore organization / positive regulation of attachment of spindle microtubules to kinetochore / meiotic chromosome segregation / mitotic spindle pole body / attachment of spindle microtubules to kinetochore / condensed chromosome, centromeric region / attachment of mitotic spindle microtubules to kinetochore / spindle pole body / protein localization to kinetochore / positive regulation of microtubule polymerization / mitotic spindle organization / chromosome segregation / 加水分解酵素; 酸無水物に作用; GTPに作用・細胞または細胞小器官の運動に関与 / spindle microtubule / structural constituent of cytoskeleton / 紡錘体 / 動原体 / microtubule cytoskeleton organization / mitotic cell cycle / 微小管 / hydrolase activity / 細胞分裂 / GTPase activity / protein-containing complex binding / GTP binding / identical protein binding / metal ion binding / 細胞核 / 細胞質類似検索 - 分子機能 DASH complex subunit Dam1 / DASH complex subunit Dam1 / Kinetochore protein Nuf2, N-terminal / Nuf2, N-terminal domain superfamily / Nuf2 family / Kinetochore protein Ndc80 / Ndc80 domain superfamily / Domain of unknown function DUF5595 / HEC/Ndc80p family / Domain of unknown function (DUF5595) ...DASH complex subunit Dam1 / DASH complex subunit Dam1 / Kinetochore protein Nuf2, N-terminal / Nuf2, N-terminal domain superfamily / Nuf2 family / Kinetochore protein Ndc80 / Ndc80 domain superfamily / Domain of unknown function DUF5595 / HEC/Ndc80p family / Domain of unknown function (DUF5595) / Tubulin-beta mRNA autoregulation signal. / Alpha tubulin / Beta tubulin, autoregulation binding site / Beta tubulin / チューブリン / Tubulin, C-terminal / Tubulin C-terminal domain / Tubulin, conserved site / Tubulin subunits alpha, beta, and gamma signature. / Tubulin/FtsZ family, C-terminal domain / Tubulin/FtsZ-like, C-terminal domain / Tubulin/FtsZ, C-terminal / Tubulin/FtsZ, 2-layer sandwich domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ family, GTPase domain / Tubulin/FtsZ, GTPase domain / Tubulin/FtsZ, GTPase domain superfamily類似検索 - ドメイン・相同性 Tubulin alpha-1A chain / Tubulin beta chain / Kinetochore protein NUF2 / Kinetochore protein NDC80 / DASH complex subunit DAM1類似検索 - 構成要素 |
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生物種 | ![](img/tx_yeast.gif) ![](data/taxo/icon/Saccharomyces_cerevisiae_S.png) Saccharomyces cerevisiae (パン酵母) / ![](img/tx_mammal.gif) ![](data/taxo/icon/Sus_scrofa_domestica_S.png) Sus scrofa (ブタ) |
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手法 | 単粒子再構成法 / クライオ電子顕微鏡法 / 解像度: 3.54 Å |
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データ登録者 | Muir KW / Barford D |
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資金援助 | 英国, 2件 Organization | Grant number | 国 |
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UK Research and Innovation (UKRI) | MC_UP_1201/6 | 英国 | Cancer Research UK | C576/A14109 | 英国 |
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引用 | ジャーナル: Biorxiv / 年: 2023 タイトル: Mechanism of outer kinetochore assembly on microtubules and its regulation by mitotic error correction 著者: Muir KW / Batters C / Dendooven T / Yang J / Zhang Z / Burt A / Barford D |
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履歴 | 登録 | 2023年8月23日 | - |
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ヘッダ(付随情報) 公開 | 2024年4月3日 | - |
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マップ公開 | 2024年4月3日 | - |
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更新 | 2024年4月3日 | - |
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現状 | 2024年4月3日 | 処理サイト: PDBe / 状態: 公開 |
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