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TitleArchitecture of the ESCPE-1 membrane coat.
Journal, issue, pagesNat Struct Mol Biol, Vol. 30, Issue 7, Page 958-969, Year 2023
Publish dateJun 15, 2023
AuthorsCarlos Lopez-Robles / Stefano Scaramuzza / Elsa N Astorga-Simon / Morié Ishida / Chad D Williamson / Soledad Baños-Mateos / David Gil-Carton / Miguel Romero-Durana / Ander Vidaurrazaga / Juan Fernandez-Recio / Adriana L Rojas / Juan S Bonifacino / Daniel Castaño-Díez / Aitor Hierro /
PubMed AbstractRecycling of membrane proteins enables the reuse of receptors, ion channels and transporters. A key component of the recycling machinery is the endosomal sorting complex for promoting exit 1 (ESCPE-1) ...Recycling of membrane proteins enables the reuse of receptors, ion channels and transporters. A key component of the recycling machinery is the endosomal sorting complex for promoting exit 1 (ESCPE-1), which rescues transmembrane proteins from the endolysosomal pathway for transport to the trans-Golgi network and the plasma membrane. This rescue entails the formation of recycling tubules through ESCPE-1 recruitment, cargo capture, coat assembly and membrane sculpting by mechanisms that remain largely unknown. Herein, we show that ESCPE-1 has a single-layer coat organization and suggest how synergistic interactions between ESCPE-1 protomers, phosphoinositides and cargo molecules result in a global arrangement of amphipathic helices to drive tubule formation. Our results thus define a key process of tubule-based endosomal sorting.
External linksNat Struct Mol Biol / PubMed:37322239 / PubMed Central
MethodsEM (subtomogram averaging) / X-ray diffraction
Resolution2.5 - 10.0 Å
Structure data

15413

8afz

EMDB-15413, PDB-8afz:
Architecture of the ESCPE-1 membrane coat
Method: EM (subtomogram averaging) / Resolution: 10.0 Å

PDB-8a1g:
Structure of the SNX1-SNX5 complex
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-8abq:
Structure of the SNX1-SNX5 complex, Pt derivative
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

Chemicals

ChemComp-POL:
N-PROPANOL / Propan-1-ol

ChemComp-HOH:
WATER / Water

ChemComp-PT:
Unknown entry

Source
  • homo sapiens (human)
KeywordsPROTEIN TRANSPORT / SNX / Membrane trafficking. / TRANSPORT PROTEIN / Membrane trafficking / sorting nexins / PX domain / BAR domain / endosomes / retrograde transport / endocytic recycling / cargo recognition / protein coat / membrane recruitment / membrane deformation / membrane tubules.

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