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TitleLY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection.
Journal, issue, pagesbioRxiv, Year 2020
Publish dateOct 9, 2020
AuthorsBryan E Jones / Patricia L Brown-Augsburger / Kizzmekia S Corbett / Kathryn Westendorf / Julian Davies / Thomas P Cujec / Christopher M Wiethoff / Jamie L Blackbourne / Beverly A Heinz / Denisa Foster / Richard E Higgs / Deepa Balasubramaniam / Lingshu Wang / Roza Bidshahri / Lucas Kraft / Yuri Hwang / Stefanie Žentelis / Kevin R Jepson / Rodrigo Goya / Maia A Smith / David W Collins / Samuel J Hinshaw / Sean A Tycho / Davide Pellacani / Ping Xiang / Krithika Muthuraman / Solmaz Sobhanifar / Marissa H Piper / Franz J Triana / Jorg Hendle / Anna Pustilnik / Andrew C Adams / Shawn J Berens / Ralph S Baric / David R Martinez / Robert W Cross / Thomas W Geisbert / Viktoriya Borisevich / Olubukola Abiona / Hayley M Belli / Maren de Vries / Adil Mohamed / Meike Dittmann / Marie Samanovic / Mark J Mulligan / Jory A Goldsmith / Ching-Lin Hsieh / Nicole V Johnson / Daniel Wrapp / Jason S McLellan / Bryan C Barnhart / Barney S Graham / John R Mascola / Carl L Hansen / Ester Falconer
PubMed AbstractSARS-CoV-2 poses a public health threat for which therapeutic agents are urgently needed. Herein, we report that high-throughput microfluidic screening of antigen-specific B-cells led to the ...SARS-CoV-2 poses a public health threat for which therapeutic agents are urgently needed. Herein, we report that high-throughput microfluidic screening of antigen-specific B-cells led to the identification of LY-CoV555, a potent anti-spike neutralizing antibody from a convalescent COVID-19 patient. Biochemical, structural, and functional characterization revealed high-affinity binding to the receptor-binding domain, ACE2 binding inhibition, and potent neutralizing activity. In a rhesus macaque challenge model, prophylaxis doses as low as 2.5 mg/kg reduced viral replication in the upper and lower respiratory tract. These data demonstrate that high-throughput screening can lead to the identification of a potent antiviral antibody that protects against SARS-CoV-2 infection.
ONE SENTENCE SUMMARY: LY-CoV555, an anti-spike antibody derived from a convalescent COVID-19 patient, potently neutralizes SARS-CoV-2 and protects the upper and lower airways of non-human primates against SARS-CoV-2 infection.
External linksbioRxiv / PubMed:33024963 / PubMed Central
MethodsEM (single particle)
Resolution3.27 Å
Structure data

23156

7l3n

EMDB-23156, PDB-7l3n:
SARS-CoV 2 Spike Protein bound to LY-CoV555
Method: EM (single particle) / Resolution: 3.27 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

Source
  • severe acute respiratory syndrome coronavirus 2
  • homo sapiens (human)
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / Glycoprotein / VIRAL PROTEIN-IMMUNE SYSTEM complex

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