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-Structure paper
Title | Synthesis and Biological Validation of a Harmine-Based, Central Nervous System (CNS)-Avoidant, Selective, Human beta-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor. |
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Journal, issue, pages | J. Med. Chem., Vol. 63, Page 2986-3003, Year 2020 |
Publish date | Nov 5, 2019 (structure data deposition date) |
Authors | Kumar, K. / Wang, P. / Wilson, J. / Zlatanic, V. / Berrouet, C. / Khamrui, S. / Secor, C. / Swartz, E.A. / Lazarus, M. / Sanchez, R. ...Kumar, K. / Wang, P. / Wilson, J. / Zlatanic, V. / Berrouet, C. / Khamrui, S. / Secor, C. / Swartz, E.A. / Lazarus, M. / Sanchez, R. / Stewart, A.F. / Garcia-Ocana, A. / DeVita, R.J. |
External links | J. Med. Chem. / PubMed:32003560 |
Methods | X-ray diffraction |
Resolution | 2.95 Å |
Structure data | PDB-6uwy: |
Chemicals | ChemComp-QKG: ChemComp-PG4: ChemComp-HOH: |
Source |
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Keywords | TRANSFERASE/TRANSFERASE INHIBITOR / kinase / TRANSFERASE / TRANSFERASE-TRANSFERASE Inhibitor complex |