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TitleeIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
Journal, issue, pagesScience, Vol. 364, Issue 6439, Page 491-495, Year 2019
Publish dateMay 3, 2019
AuthorsLillian R Kenner / Aditya A Anand / Henry C Nguyen / Alexander G Myasnikov / Carolin J Klose / Lea A McGeever / Jordan C Tsai / Lakshmi E Miller-Vedam / Peter Walter / Adam Frost /
PubMed AbstractThe integrated stress response (ISR) tunes the rate of protein synthesis. Control is exerted by phosphorylation of the general translation initiation factor eIF2. eIF2 is a guanosine triphosphatase ...The integrated stress response (ISR) tunes the rate of protein synthesis. Control is exerted by phosphorylation of the general translation initiation factor eIF2. eIF2 is a guanosine triphosphatase that becomes activated by eIF2B, a two-fold symmetric and heterodecameric complex that functions as eIF2's dedicated nucleotide exchange factor. Phosphorylation converts eIF2 from a substrate into an inhibitor of eIF2B. We report cryo-electron microscopy structures of eIF2 bound to eIF2B in the dephosphorylated state. The structures reveal that the eIF2B decamer is a static platform upon which one or two flexible eIF2 trimers bind and align with eIF2B's bipartite catalytic centers to catalyze nucleotide exchange. Phosphorylation refolds eIF2α, allowing it to contact eIF2B at a different interface and, we surmise, thereby sequestering it into a nonproductive complex.
External linksScience / PubMed:31048491 / PubMed Central
MethodsEM (single particle)
Resolution3.03 - 3.21 Å
Structure data

0649

6o81

EMDB-0649, PDB-6o81:
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation initiation factor 2 from Homo sapiens
Method: EM (single particle) / Resolution: 3.21 Å

0651

6o85

EMDB-0651, PDB-6o85:
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic translation initiation factor 2 from Homo sapiens
Method: EM (single particle) / Resolution: 3.03 Å

0664

6o9z

EMDB-0664, PDB-6o9z:
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic translation initiation factor 2 from Homo sapiens
Method: EM (single particle) / Resolution: 3.03 Å

Chemicals

ChemComp-C7B:
2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide / ISRIB

Source
  • homo sapiens (human)
KeywordsTRANSLATION / Translation initiation / eukaryotic translation initiation factor 2B / eukaryotic translation initiation factor 2

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