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-Structure paper
Title | Structural basis of PROTAC cooperative recognition for selective protein degradation. |
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Journal, issue, pages | Nat. Chem. Biol., Vol. 13, Page 514-521, Year 2017 |
Publish date | Aug 24, 2016 (structure data deposition date) |
Authors | Gadd, M.S. / Testa, A. / Lucas, X. / Chan, K.H. / Chen, W. / Lamont, D.J. / Zengerle, M. / Ciulli, A. |
External links | Nat. Chem. Biol. / PubMed:28288108 |
Methods | X-ray diffraction |
Resolution | 2.7 Å |
Structure data | PDB-5t35: |
Chemicals | ChemComp-759: ChemComp-HOH: |
Source |
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Keywords | LIGASE / PROTAC complex / targeted degradation / chromatin reader / ubiquitin ligase / bifunctional ligand |