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Structure paper

TitleStructure of the STRA6 receptor for retinol uptake.
Journal, issue, pagesScience, Vol. 353, Issue 6302, Year 2016
Publish dateAug 26, 2016
AuthorsYunting Chen / Oliver B Clarke / Jonathan Kim / Sean Stowe / Youn-Kyung Kim / Zahra Assur / Michael Cavalier / Raquel Godoy-Ruiz / Desiree C von Alpen / Chiara Manzini / William S Blaner / Joachim Frank / Loredana Quadro / David J Weber / Lawrence Shapiro / Wayne A Hendrickson / Filippo Mancia /
PubMed AbstractVitamin A homeostasis is critical to normal cellular function. Retinol-binding protein (RBP) is the sole specific carrier in the bloodstream for hydrophobic retinol, the main form in which vitamin A ...Vitamin A homeostasis is critical to normal cellular function. Retinol-binding protein (RBP) is the sole specific carrier in the bloodstream for hydrophobic retinol, the main form in which vitamin A is transported. The integral membrane receptor STRA6 mediates cellular uptake of vitamin A by recognizing RBP-retinol to trigger release and internalization of retinol. We present the structure of zebrafish STRA6 determined to 3.9-angstrom resolution by single-particle cryo-electron microscopy. STRA6 has one intramembrane and nine transmembrane helices in an intricate dimeric assembly. Unexpectedly, calmodulin is bound tightly to STRA6 in a noncanonical arrangement. Residues involved with RBP binding map to an archlike structure that covers a deep lipophilic cleft. This cleft is open to the membrane, suggesting a possible mode for internalization of retinol through direct diffusion into the lipid bilayer.
External linksScience / PubMed:27563101 / PubMed Central
MethodsEM (single particle) / X-ray diffraction
Resolution1.739 - 3.9 Å
Structure data

8315

5sy1

EMDB-8315, PDB-5sy1:
Structure of the STRA6 receptor for retinol uptake in complex with calmodulin
Method: EM (single particle) / Resolution: 3.9 Å

PDB-5k8q:
Crystal Structure of Calcium-loaded Calmodulin in complex with STRA6 CaMBP2-site peptide.
Method: X-RAY DIFFRACTION / Resolution: 1.739 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-IMD:
IMIDAZOLE / Imidazole

ChemComp-HOH:
WATER / Water

ChemComp-CLR:
CHOLESTEROL / Cholesterol

Source
  • danio rerio (zebrafish)
  • spodoptera frugiperda (fall armyworm)
  • homo sapiens (human)
KeywordsMETAL BINDING PROTEIN / Calmodulin / STRA6 / peptide complex / unique fold / MEMBRANE PROTEIN/CALCIUM BINDING PROTEIN / Vitamin A / retinol / membrane / MEMBRANE PROTEIN-CALCIUM BINDING PROTEIN complex

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