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Title | Discovery of 4-Aryl-5,6,7,8-tetrahydroisoquinolines as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors: In Vivo Evaluation in Rodents and Cynomolgus Monkeys. |
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Journal, issue, pages | J. Med. Chem., Vol. 58, Page 8054-8065, Year 2015 |
Publish date | Apr 24, 2015 (structure data deposition date) |
Authors | Martin, R.E. / Aebi, J.D. / Hornsperger, B. / Krebs, H.J. / Kuhn, B. / Kuglstatter, A. / Alker, A.M. / Marki, H.P. / Muller, S. / Burger, D. ...Martin, R.E. / Aebi, J.D. / Hornsperger, B. / Krebs, H.J. / Kuhn, B. / Kuglstatter, A. / Alker, A.M. / Marki, H.P. / Muller, S. / Burger, D. / Ottaviani, G. / Riboulet, W. / Verry, P. / Tan, X. / Amrein, K. / Mayweg, A.V. |
External links | J. Med. Chem. / PubMed:26403853 |
Methods | X-ray diffraction |
Resolution | 3.2 Å |
Structure data | PDB-4zgx: |
Chemicals | ChemComp-HEM: ChemComp-QHC: ChemComp-HOH: |
Source |
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Keywords | OXIDOREDUCTASE / CYTOCHROME P450 / CYP11B2 / ALDOSTERONE SYNTHASE |