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-Structure paper
Title | Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis thymidylate synthase-dihydrofolate reductase. |
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Journal, issue, pages | Bioorg. Med. Chem. Lett., Vol. 24, Page 4158-4161, Year 2014 |
Publish date | Apr 1, 2014 (structure data deposition date) |
Authors | Kumar, V.P. / Cisneros, J.A. / Frey, K.M. / Castellanos-Gonzalez, A. / Wang, Y. / Gangjee, A. / White, A.C. / Jorgensen, W.L. / Anderson, K.S. |
External links | Bioorg. Med. Chem. Lett. / PubMed:25127103 |
Methods | X-ray diffraction |
Resolution | 2.78 - 3.449 Å |
Structure data | PDB-4q0d: PDB-4q0e: |
Chemicals | ChemComp-NDP: ChemComp-UFP: ChemComp-2XB: ChemComp-MTX: ChemComp-HOH: |
Source |
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Keywords | transferase/transferase inhibitor / bifunctional enzyme / transferase / oxidoreductase / transferase-transferase inhibitor complex |