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TitleInsertion domain within mammalian mitochondrial translation initiation factor 2 serves the role of eubacterial initiation factor 1.
Journal, issue, pagesProc Natl Acad Sci U S A, Vol. 108, Issue 10, Page 3918-3923, Year 2011
Publish dateMar 8, 2011
AuthorsAymen S Yassin / Md Emdadul Haque / Partha P Datta / Kevin Elmore / Nilesh K Banavali / Linda L Spremulli / Rajendra K Agrawal /
PubMed AbstractMitochondria have their own translational machineries for the synthesis of thirteen polypeptide chains that are components of the complexes that participate in the process of oxidative ...Mitochondria have their own translational machineries for the synthesis of thirteen polypeptide chains that are components of the complexes that participate in the process of oxidative phosphorylation (or ATP generation). Translation initiation in mammalian mitochondria requires two initiation factors, IF2(mt) and IF3(mt), instead of the three that are present in eubacteria. The mammalian IF2(mt) possesses a unique 37 amino acid insertion domain, which is known to be important for the formation of the translation initiation complex. We have obtained a three-dimensional cryoelectron microscopic map of the mammalian IF2(mt) in complex with initiator fMet-tRNA(iMet) and the eubacterial ribosome. We find that the 37 amino acid insertion domain interacts with the same binding site on the ribosome that would be occupied by the eubacterial initiation factor IF1, which is absent in mitochondria. Our finding suggests that the insertion domain of IF2(mt) mimics the function of eubacterial IF1, by blocking the ribosomal aminoacyl-tRNA binding site (A site) at the initiation step.
External linksProc Natl Acad Sci U S A / PubMed:21368145 / PubMed Central
MethodsEM (single particle)
Resolution10.8 Å
Structure data

1854

3izz

EMDB-1854: An insertion domain within mammalian mitochondrial translation initiation factor 2 serves the role of eubacterial initiation factor 1
PDB-3izz: Models for ribosome components that are nearest neighbors to the bovine mitochondrial initiation factor2 bound to the E. Coli ribosome
Method: EM (single particle) / Resolution: 10.8 Å

1855

3izy

EMDB-1855: An insertion domain within mammalian mitochondrial translation initiation factor 2 serves the role of eubacterial initiation factor 1
PDB-3izy: Mammalian mitochondrial translation initiation factor 2
Method: EM (single particle) / Resolution: 10.8 Å

Source
  • escherichia coli (E. coli)
  • bos taurus (cattle)
KeywordsRNA / RIBOSOMAL PROTEIN / translation initiation factor 2 / IF2 / E coli / 70S

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