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TitleThe crystal structure of coxsackievirus A21 and its interaction with ICAM-1.
Journal, issue, pagesStructure, Vol. 13, Issue 7, Page 1019-1033, Year 2005
Publish dateDec 9, 2005
AuthorsChuan Xiao / Carol M Bator-Kelly / Elizabeth Rieder / Paul R Chipman / Alister Craig / Richard J Kuhn / Eckard Wimmer / Michael G Rossmann /
PubMed AbstractCVA21 and polioviruses both belong to the Enterovirus genus in the family of Picornaviridae, whereas rhinoviruses form a distinct picornavirus genus. Nevertheless, CVA21 and the major group of human ...CVA21 and polioviruses both belong to the Enterovirus genus in the family of Picornaviridae, whereas rhinoviruses form a distinct picornavirus genus. Nevertheless, CVA21 and the major group of human rhinoviruses recognize intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, whereas polioviruses use poliovirus receptor. The crystal structure of CVA21 has been determined to 3.2 A resolution. Its structure has greater similarity to poliovirus structures than to other known picornavirus structures. Cryo-electron microscopy (cryo-EM) was used to determine an 8.0 A resolution structure of CVA21 complexed with an ICAM-1 variant, ICAM-1(Kilifi). The cryo-EM map was fitted with the crystal structures of ICAM-1 and CVA21. Significant differences in the structure of CVA21 with respect to the poliovirus structures account for the inability of ICAM-1 to bind polioviruses. The interface between CVA21 and ICAM-1 has shape and electrostatic complementarity with many residues being conserved among those CVAs that bind ICAM-1.
External linksStructure / PubMed:16004874
MethodsEM (single particle) / X-ray diffraction
Resolution3.2 - 8.0 Å
Structure data

1114

1z7z

EMDB-1114: The crystal structure of coxsackievirus A21 and its interaction with ICAM-1.
PDB-1z7z: Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi
Method: EM (single particle) / Resolution: 8.0 Å

PDB-1z7s:
The crystal structure of coxsackievirus A21
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-MYR:
MYRISTIC ACID / Myristic acid

ChemComp-G:
GUANOSINE-5'-MONOPHOSPHATE / Guanosine monophosphate

ChemComp-HOH:
WATER / Water

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

Source
  • human coxsackievirus a21
  • homo sapiens (human)
KeywordsVIRUS / PICORNAVIRUS / Coxsackievirus / A21 / Capsid Protein / Viral Protein / Icosahedral virus / Virus/Receptor / ICAM-1 / Kilifi / CD54 / Human Coxsackievirus A21 / virus-receptor complex

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