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TitleAtlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA.1/BA.1.1/BA.2/BA.3.
Journal, issue, pagesImmunity, Vol. 55, Issue 8, Page 1501-11514.e3, Year 2022
Publish dateAug 9, 2022
AuthorsMin Huang / Lili Wu / Anqi Zheng / Yufeng Xie / Qingwen He / Xiaoyu Rong / Pu Han / Pei Du / Pengcheng Han / Zengyuan Zhang / Runchu Zhao / Yunfei Jia / Linjie Li / Bin Bai / Ziliang Hu / Shixiong Hu / Sheng Niu / Yu Hu / Honghui Liu / Bo Liu / Kaige Cui / Weiwei Li / Xin Zhao / Kefang Liu / Jianxun Qi / Qihui Wang / George Fu Gao /
PubMed AbstractSARS-CoV-2 Omicron variant has presented significant challenges to current antibodies and vaccines. Herein, we systematically compared the efficacy of 50 human monoclonal antibodies (mAbs), covering ...SARS-CoV-2 Omicron variant has presented significant challenges to current antibodies and vaccines. Herein, we systematically compared the efficacy of 50 human monoclonal antibodies (mAbs), covering the seven identified epitope classes of the SARS-CoV-2 RBD, against Omicron sub-variants BA.1, BA.1.1, BA.2, and BA.3. Binding and pseudovirus-based neutralizing assays revealed that 37 of the 50 mAbs lost neutralizing activities, whereas the others displayed variably decreased activities against the four Omicron sub-variants. BA.2 was found to be more sensitive to RBD-5 antibodies than the other sub-variants. Furthermore, a quaternary complex structure of BA.1 RBD with three mAbs showing different neutralizing potencies against Omicron provided a basis for understanding the immune evasion of Omicron sub-variants and revealed the lack of G446S mutation accounting for the sensitivity of BA.2 to RBD-5 mAbs. Our results may guide the application of the available mAbs and facilitate the development of universal therapeutic antibodies and vaccines against COVID-19.
External linksImmunity / PubMed:35777362 / PubMed Central
MethodsEM (single particle)
Resolution2.74 Å
Structure data

32944

7x1m

EMDB-32944, PDB-7x1m:
The complex structure of Omicron BA.1 RBD with BD604, S309,and S304
Method: EM (single particle) / Resolution: 2.74 Å

Source
  • homo sapiens (human)
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / antibody viral protein complex / VIRAL PROTEIN / VIRAL PROTEIN-IMMUNE SYSTEM complex

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