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TitleStructural basis for specific recognition of single-stranded RNA by Toll-like receptor 13.
Journal, issue, pagesNat Struct Mol Biol, Vol. 22, Issue 10, Page 782-787, Year 2015
Publish dateAug 31, 2015
AuthorsWen Song / Jia Wang / Zhifu Han / Yifan Zhang / Heqiao Zhang / Weiguang Wang / Junbiao Chang / Bingshu Xia / Shilong Fan / Dekai Zhang / Jiawei Wang / Hong-Wei Wang / Jijie Chai /
PubMed AbstractToll-like receptors (TLRs) have crucial roles in innate immunity, functioning as pattern-recognition receptors. TLR13 recognizes a conserved sequence from bacterial 23S rRNA and then triggers an ...Toll-like receptors (TLRs) have crucial roles in innate immunity, functioning as pattern-recognition receptors. TLR13 recognizes a conserved sequence from bacterial 23S rRNA and then triggers an immune response. Here we report the crystal structure of the mouse TLR13 ectodomain bound by a 13-nt single-stranded (ss) RNA derived from 23S rRNA. The ssRNA induces TLR13 dimerization but assumes a stem-loop-like structure that is completely different from that in the bacterial ribosome but nevertheless is crucial for TLR13 recognition. Most of the RNA nucleotides are splayed out to make base-specific contacts with the concave surface of TLR13, and RNA-specific interactions are important to allow TLR13 to distinguish RNA from DNA. Interestingly, a viral-derived 16-nt ssRNA predicted to form a similar stem-loop-like structure also induces TLR13 activation. Together, our results reveal the structural mechanism of TLR13's sequence- and conformation-specific recognition of ssRNA.
External linksNat Struct Mol Biol / PubMed:26323037
MethodsEM (single particle) / X-ray diffraction
Resolution2.3 - 4.87 Å
Structure data

EMDB-3125:
Structural basis for specific recognition of single-stranded RNA by toll-like receptor 13
Method: EM (single particle) / Resolution: 4.87 Å

PDB-4z0c:
Crystal structure of TLR13-ssRNA13 complex
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose / N-Acetylglucosamine

ChemComp-HOH:
WATER / Water

Source
  • mus musculus (house mouse)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / immune receptor / Toll-like receptor / ssRNA

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