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TitleA new class of highly potent, broadly neutralizing antibodies isolated from viremic patients infected with dengue virus.
Journal, issue, pagesNat Immunol, Vol. 16, Issue 2, Page 170-177, Year 2015
Publish dateDec 15, 2014
AuthorsWanwisa Dejnirattisai / Wiyada Wongwiwat / Sunpetchuda Supasa / Xiaokang Zhang / Xinghong Dai / Alexander Rouvinski / Amonrat Jumnainsong / Carolyn Edwards / Nguyen Than Ha Quyen / Thaneeya Duangchinda / Jonathan M Grimes / Wen-Yang Tsai / Chih-Yun Lai / Wei-Kung Wang / Prida Malasit / Jeremy Farrar / Cameron P Simmons / Z Hong Zhou / Felix A Rey / Juthathip Mongkolsapaya / Gavin R Screaton /
PubMed AbstractDengue is a rapidly emerging, mosquito-borne viral infection, with an estimated 400 million infections occurring annually. To gain insight into dengue immunity, we characterized 145 human monoclonal ...Dengue is a rapidly emerging, mosquito-borne viral infection, with an estimated 400 million infections occurring annually. To gain insight into dengue immunity, we characterized 145 human monoclonal antibodies (mAbs) and identified a previously unknown epitope, the envelope dimer epitope (EDE), that bridges two envelope protein subunits that make up the 90 repeating dimers on the mature virion. The mAbs to EDE were broadly reactive across the dengue serocomplex and fully neutralized virus produced in either insect cells or primary human cells, with 50% neutralization in the low picomolar range. Our results provide a path to a subunit vaccine against dengue virus and have implications for the design and monitoring of future vaccine trials in which the induction of antibody to the EDE should be prioritized.
External linksNat Immunol / PubMed:25501631 / PubMed Central
MethodsEM (single particle)
Resolution10.24 Å
Structure data

EMDB-2818:
Dengue virus serotype 2 with Fab fragments of human antibody B7
Method: EM (single particle) / Resolution: 10.24 Å

Source
  • Homo sapiens (human)

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