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Title | Three-dimensional visualization of forming Hepatitis C virus-like particles by electron-tomography. |
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Journal, issue, pages | Virology, Vol. 430, Issue 2, Page 120-126, Year 2012 |
Publish date | Sep 1, 2012 |
Authors | Daniel Badia-Martinez / Bibiana Peralta / German Andrés / Milagros Guerra / David Gil-Carton / Nicola G A Abrescia / |
PubMed Abstract | Hepatitis C virus infects almost 170 million people per year but its assembly pathway, architecture and the structures of its envelope proteins are poorly understood. Using electron tomography of ...Hepatitis C virus infects almost 170 million people per year but its assembly pathway, architecture and the structures of its envelope proteins are poorly understood. Using electron tomography of plastic-embedded sections of insect cells, we have visualized the morphogenesis of recombinant Hepatitis C virus-like particles. Our data provide a three-dimensional sketch of viral assembly at the endoplasmic reticulum showing different budding stages and contiguity of buds. This latter phenomenon could play an important role during the assembly of wt-HCV and explain the size-heterogeneity of its particles. |
External links | Virology / PubMed:22657942 |
Methods | EM (tomography) |
Structure data | EMDB-2101: |
Source |
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